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Cancers, Vol. 14, Pages 4123: Recent Trends in Nanomedicine-Based Strategies to Overcome Multidrug Resistance in Tumors
lin Cancer is the leading cause of economic and health burden worldwide. The commonly used approaches for the treatment of cancer are chemotherapy, radiotherapy, and surgery. Chemotherapy frequently results in undesirable side effects, and cancer cells may develop resistance. Combating drug resistance is a challenging task in cancer treatment. Drug resistance may be intrinsic or acquired and can be due to genetic factors, growth factors, the increased efflux of drugs, DNA repair, and the metabolism of xenobiotics. The strategies used to combat drug resistance include the nanomedicine-based targeted delivery of drugs an...
Source: Cancers - August 26, 2022 Category: Cancer & Oncology Authors: Muhammad Muzamil Khan Vladimir P. Torchilin Tags: Review Source Type: research

Reversal of Multidrug Resistance in an Epirubicin-Resistant Gastric Cancer Cell Subline
Conclusions: ABCB1 knockdown decreased EPI efflux and increased EPI sensitivity in AGS/EPI cells. This result provides a novel strategy for targeted gene therapy to reverse EPI resistance in gastric cancer. PMID: 29801407 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - May 31, 2018 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy
Publication date: 30 July 2018 Source:International Journal of Pharmaceutics, Volume 546, Issues 1–2 Author(s): Jun Li, Huamin Liang, Jing Liu, Ziyuan Wang Poly (amidoamine) (PAMAM) dendrimers are well-defined, highly branched macromolecules with numerous active amine groups on the surface. Because of their unique properties, PAMAM dendrimers have steadily grown in popularity in drug delivery, gene therapy, medical imaging and diagnostic application. This review focuses on the recent developments on the application in PAMAM dendrimers as effective carriers for drug and gene (pDNA, siRNA) delivery in cancer therapy, incl...
Source: International Journal of Pharmaceutics - May 26, 2018 Category: Drugs & Pharmacology Source Type: research

Reversing of multidrug resistance breast cancer by co-delivery of P-gp siRNA and doxorubicin via folic acid-modified core-shell nanomicelles
Publication date: 1 February 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 138 Author(s): Yang Wu, Yu Zhang, Wei Zhang, Chunlong Sun, Jianzhong Wu, Jinhai Tang Multidrug resistance (MDR) remains one of major limitation for the successful treatment of many cancers including breast cancer. Co-delivery of chemotherapeutic drugs and small interfering RNA (siRNA) has been developed because of its ability to generate synergistic anticancer effects via different mechanisms of action, to reverse MDR and increase the efficacy of chemotherapeutic drugs in cancer therapy. Herein, we employed a kind of efficient m...
Source: Colloids and Surfaces B: Biointerfaces - December 2, 2015 Category: Biochemistry Source Type: research

Increased efficiency of testicular tumor chemotherapy by ultrasound microbubble-mediated targeted transfection of siMDR1.
Authors: He Y, Bi Y, Ji XJ, Wei G Abstract The MDR1 gene encoding P-glycoprotein (P-gp) is an ATP-dependent drug efflux transporter and is related to drug resistance of yolk sac tumors. Drug resistence may be an important factor for the low efficiency of chemotherapy in the treatment of testicular tumors. P-gp, encoded by the MDR1 gene, is an ATP-binding cassette transporter. P-gp exhibits high expression in capillary endothelial cells of the testis and prevents the intracellular accumulation of chemotherapy agents in testicular tumor cells, resulting in drug resistance. In the present study, we aimed to use specif...
Source: Oncology Reports - September 11, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Phospholipid-modified PEI-based nanocarriers for in vivo siRNA therapeutics against multidrug-resistant tumors
p; V P Torchilin
Source: Gene Therapy - October 30, 2014 Category: Genetics & Stem Cells Authors: S EssexG NavarroP SabhachandaniA ChordiaM TrivediS MovassaghianV P Torchilin Source Type: research

Polymeric delivery of siRNA for dual silencing of Mcl-1 and P-glycoprotein and apoptosis induction in drug-resistant breast cancer cells
& H Uludağ
Source: Cancer Gene Therapy - March 1, 2013 Category: Cancer & Oncology Authors: H M AliabadiP MahdipoorH Uludağ Tags: lipophilic polymers Mcl-1 multidrug resistance P-glycoprotein siRNA delivery Source Type: research