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Chondroitin sulfate modified chitosan nanoparticles as an efficient and targeted gene delivery vehicle to chondrocytes
In conclusion, CH-CS nanoparticles can be considered as a candidate for gene therapy purposes in cartilage diseases.PMID:36049252 | DOI:10.1016/j.colsurfb.2022.112786
Source: Colloids and Surfaces - September 1, 2022 Category: Biotechnology Authors: Naghmeh Akbari Moghadam Fatemeh Bagheri Mohamadreza Baghaban Eslaminejad Source Type: research

Cyclin D1 regulates osteoarthritis chondrocyte apoptosis via WNT3/ β-catenin signalling.
Conclusions: Cyclin D1 regulated chondrocyte proliferation and apoptosis through Wnt3/β-catenin instead of Wnt10a/β-catenin signalling pathway. PMID: 31155960 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - June 4, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis
This study demonstrated that MGF treatment can inhibit the pathological apoptosis of OA chondrocytes and promote the proliferation, migration and matrix synthesis of the chondrocytes. The results also demonstrate that the degeneration of OA cartilage can be delayed by MGF treatment partially via PERK‐regulated UPR and suggest a potential therapeutic application of MGF for OA treatment. This article is protected by copyright. All rights reserved.
Source: Journal of Tissue Engineering and Regenerative Medicine - June 9, 2017 Category: Biotechnology Authors: Yang Song, Kang Xu, Can Yu, Lili Dong, Peixing Chen, Yonggang Lv, Martin Y.M. Chiang, Linhao Li, Wanqian Liu, Li Yang Tags: RESEARCH ARTICLE Source Type: research