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Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease
In conclusion, our findings confirmed that CAV1 exerts a protective effect against vascular injury by inhibiting oxidative stress and inflammation through the PKC/MAPK pathway. Therefore, restoration of CAV1 may have clinical benefits in reducing APAP-induced vascular damage in NAFLD patients.PMID:36596386 | DOI:10.1016/j.freeradbiomed.2022.12.095
Source: Free Radical Biology and Medicine - January 3, 2023 Category: Biology Authors: Dongdong Fu Shuai Wu Xiangfu Jiang Tingyu You Yu Li Jiao Xin Xiaowen Feng Jiagen Wen Yan Huang Chengmu Hu Source Type: research

High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease
Publication date: July 2018Source: Redox Biology, Volume 17Author(s): Firas Alhasson, Ratanesh Kumar Seth, Sutapa Sarkar, Diana A. Kimono, Muayad S. Albadrani, Diptadip Dattaroy, Varun Chandrashekaran, Geoffrey I. Scott, Samir Raychoudhury, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, Saurabh ChatterjeeAbstractHigh circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E1-mediated oxidative stress and circulating leptin in NAFLD...
Source: Redox Biology - July 11, 2018 Category: Biology Source Type: research

HNF-4alpha Negatively Regulates Hepcidin Expression Through BMPR1A in HepG2 Cells.
In conclusion, the present study suggests that HNF-4α has a suppressive effect on hepcidin expression by inactivating the BMP pathway, specifically via BMPR1A, in HepG2 cells. PMID: 27660075 [PubMed - as supplied by publisher]
Source: Biological Trace Element Research - September 22, 2016 Category: Biology Authors: Shi W, Wang H, Zheng X, Jiang X, Xu Z, Shen H, Li M Tags: Biol Trace Elem Res Source Type: research

Silencing of odorant binding protein gene AlinOBP4 by RNAi induces declining electrophysiological responses of Adelphocoris lineolatus to six semiochemicals
Abstract Odorant binding proteins (OBPs) are believed to be important for transporting semiochemicals through the aqueous sensillar lymph to the olfactory receptor cells within the insect antennal sensilla. Here, we injected AlinOBP4‐siRNA into the conjunctivum between prothorax and mesothorax of the lucerne plant bug, Adelphocoris lineolatus and evaluated the silencing of AlinOBP4 by reverse transcription polymerase chain reaction (RT‐PCR) analysis, quantitative real‐time PCR (qPCR) test and electroantennogram (EAG) assay. The combination of RT‐PCR and qPCR analyses revealed that the levels of messenger RNA transc...
Source: Insect Science - July 25, 2016 Category: Biology Authors: Xue ‐Ying Zhang, Xiao‐Qiang Zhu, Shao‐Hua Gu, Yan‐Le Zhou, Song‐Ying Wang, Yong‐Jun Zhang, Yu‐Yuan Guo Tags: ORIGINAL ARTICLE Source Type: research

Silencing of odorant binding protein gene AlinOBP4 by RNAi induce electrophysiological responses declining of Adelphocoris lineolatus to six semiochemicals
This article is protected by copyright. All rights reserved
Source: Insect Science - June 5, 2016 Category: Biology Authors: Xue‐Ying Zhang, Xiao‐Qiang Zhu, Shao‐Hua Gu, Yan‐Le Zhou, Song‐Ying Wang, Yong‐Jun Zhang, Yu‐Yuan Guo Tags: ORIGINAL ARTICLE Source Type: research

Tetramethylpyrazine prevents ethanol-induced hepatocyte injury via activation of nuclear factor erythroid 2-related factor 2
Publication date: 15 November 2015 Source:Life Sciences, Volume 141 Author(s): Chunfeng Lu, Yuanyuan Jiang, Feng Zhang, Jiangjuan Shao, Li Wu, Xiafei Wu, Naqi Lian, Lianyun Chen, Huanhuan Jin, Qin Chen, Yin Lu, Shizhong Zheng Aims Inhibiting the major features of alcoholic liver disease (ALD) such as lipid accumulation and oxidative stress is a promising strategy of treating ALD. Tetramethylpyrazine (TMP) has curative effects on various diseases. However, the effects of TMP on ethanol-induced hepatocyte injury and the related mechanisms remain unclear. The aim of this study is to elucidate the effects of TMP ...
Source: Life Sciences - October 4, 2015 Category: Biology Source Type: research

Essential role of NRF2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.
In conclusion, our work has revealed that in hepatocytes, Nrf2 is an essential early player in the rescue of oxidative stress by LA leading to protection against PA-mediated lipoapoptosis. PMID: 25841776 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - April 1, 2015 Category: Biology Authors: Pilar Valdecantos M, Prieto-Hontoria PL, Pardo V, Módol T, Santamaría B, Weber M, Herrero L, Serra D, Muntané J, Cuadrado A, Moreno-Aliaga MJ, Alfredo Martínez J, Valverde ÁM Tags: Free Radic Biol Med Source Type: research

Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness
Publication date: 2014 Source:Redox Biology, Volume 3 Author(s): Christopher B. Forsyth , Robin M. Voigt , Ali. Keshavarzian Chronic alcohol use can result in many pathological effects including alcoholic liver disease (ALD). While alcohol is necessary for the development of ALD, only 20–30% of alcoholics develop alcoholic steatohepatitis (ASH) with progressive liver disease leading to cirrhosis and liver failure (ALD). This suggests that while chronic alcohol consumption is necessary it is not sufficient to induce clinically relevant liver damage in the absence of a secondary risk factor. Studies in rodent models and ...
Source: Redox Biology - December 14, 2014 Category: Biology Source Type: research