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Total 1197 results found since Jan 2013.

Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells.
Abstract A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands. PMID: 32463029 [PubMed - as supplied by publisher]
Source: Chemical Communications - May 27, 2020 Category: Chemistry Authors: Kim T, Hyun HN, Heo R, Nam K, Yang K, Kim YM, Lee YS, An JY, Park JH, Choi KY, Roh YH Tags: Chem Commun (Camb) Source Type: research

IGT mediated Nanog siRNA delivery in prostate cancer cells improves chemosensitization of Epirubicin in vitro
In this report, we have successfully delivered siRNA against Nanog with the help of pentafluorobenzyl modified Internal Oligo-guanidinium transporter (IGT) that has previously shown promising results in peptide and antisense morpholino delivery. Nanog downregulation in prostate cancer cell line DU145 in serum containing media led to suppression of associated proteins such as KLF4, FAK and cMyc and also enhanced the chemosensitivity of Epirubicin, an anthracycline based drug, in DU145 cells by associated MDR-1 downregulation in vitro. These results show that IGT is a promising candidate for siRNA delivery and its conjugatio...
Source: Bioorganic and Medicinal Chemistry Letters - October 9, 2022 Category: Chemistry Authors: Shalini Gupta Ujjal Das Surajit Sinha Source Type: research

A triazolium-anchored self-immolative linker enables self-assembly-driven siRNA binding and esterase-induced release
Chemistry. 2022 Nov 8. doi: 10.1002/chem.202203311. Online ahead of print.ABSTRACTThe increased importance of RNA-based therapeutics comes with a need to develop next-generation stimuli-responsive systems capable of binding, transporting and releasing RNA oligomers. In this work, we describe triazolium-based amphiphiles capable of siRNA binding and enzyme-responsive release of the nucleic acid payload. In aqueous medium, the amphiphile selfassembles into nanocarriers that can disintegrate upon the addition of esterase. Key to the molecular design is a self-immolative linker that is anchored to the triazolium moiety and act...
Source: Chemistry - November 8, 2022 Category: Chemistry Authors: Selina Hollstein Lamiaa M A Ali Maeva Coste Julian Vogel Nadir Bettache S ébastien Ulrich Max von Delius Source Type: research

Synthesis of 2'-modified N6-methyladenosine phosphoramidites and their incorporation into siRNA
Bioorg Med Chem Lett. 2023 Jan 9:129126. doi: 10.1016/j.bmcl.2023.129126. Online ahead of print.ABSTRACTA synthesis of 2'-fluoro and 2'-methoxy N6-methyladenosine phosphoramidites and their successful incorporation into oligonucleotides is reported. 2'-fluoro and 2́-methoxy modifications of sugars in siRNAs are known to aid stability and N6-methylation modifies the potency of therapeutic silencing RNAs (siRNA). We demonstrate that a combination of those modifications incorporated into the antisense strand of siRNA leads to efficient knockdown of a target gene in cells. This work broadens the available pool of chemical mod...
Source: Bioorganic and Medicinal Chemistry Letters - January 12, 2023 Category: Chemistry Authors: Anna M Rydzik Doris Riether Dirk Gottschling Source Type: research

A bioreducible linear poly(small beta-amino ester) for siRNA delivery
, 2013, Accepted ManuscriptDOI: 10.1039/C3CC40718G, CommunicationKristen Lynn Kozielski, Stephany Yi Tzeng, Jordan J GreenDescribed here is the synthesis and characterization of a novel, bioreducible linear poly([small beta]-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 15, 2013 Category: Chemistry Authors: Kristen Lynn Kozielski Source Type: research

Lipid-mediated DNA and siRNA transfection efficiency depends on peptide headgroup
Soft Matter, 2013, 9,4472-4479DOI: 10.1039/C3SM27633C, PaperXiao-Xiang Zhang, Caroline M. LaManna, Richie E. Kohman, Thomas J. McIntosh, Xue Han, Mark W. GrinstaffLipoplex mediated transfection of DNA is highly dependent on efficient cellular uptake while siRNA transfection is not when using lipopeptides.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - April 15, 2013 Category: Chemistry Authors: Xiao-Xiang Zhang Source Type: research

Intracellular buildup reaction of active siRNA species from short RNA fragments
Chem. Commun., 2013, Accepted ManuscriptDOI: 10.1039/C3CC47529H, CommunicationHideto Maruyama, Yuko Nakasima, Satoshi Shuto, Akira Matsuda, Yoshihiro Ito, Hiroshi AbeHere we report a new strategy for buildup reaction of active siRNA species from short RNA fragments in living cells, using a chemical ligation reaction. This strategy could decrease undesired...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 2, 2013 Category: Chemistry Authors: Hideto Maruyama Source Type: research

Time resolved SAXS to study the complexation of siRNA by cationic micelles of divalent surfactants
Soft Matter, 2013, Accepted ManuscriptDOI: 10.1039/C3SM52429A, PaperSandra Ristori, Sara Falsini, Laura Ciani, Claudiu Supuran, Emanuela Di Cola, Annarosa Arcangeli, Martin InThe complexation of siRNA (small interfering RNA) with cationic micelles was studied by time dependent synchrotron SAXS. Micelles were formed by two types of divalent cationic surfactants, i.e. Gemini bis...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - December 19, 2013 Category: Chemistry Authors: Sandra Ristori Source Type: research

An intracellular buildup reaction of active siRNA species from short RNA fragments
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C3CC47529H, CommunicationHideto Maruyama, Yuko Nakashima, Satoshi Shuto, Akira Matsuda, Yoshihiro Ito, Hiroshi AbeAn intracellular buildup reaction of active siRNA species from short RNA fragments provided a potent RNAi effect without stimulation of immune response.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 24, 2013 Category: Chemistry Authors: Hideto Maruyama Source Type: research

Time resolved SAXS to study the complexation of siRNA with cationic micelles of divalent surfactants
Soft Matter, 2014, Advance ArticleDOI: 10.1039/C3SM52429A, PaperSara Falsini, Sandra Ristori, Laura Ciani, Emanuela Di Cola, Claudiu T. Supuran, Annarosa Arcangeli, Martin InThe complexation of siRNA (small interfering RNA) with cationic micelles was studied using time dependent synchrotron SAXS.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - February 7, 2014 Category: Chemistry Authors: Sara Falsini Source Type: research

Biocompatible, Chimeric Peptide-Condensed Supramolecular Nanoparticles for Tumor Cell-Specific siRNA Delivery and Gene Silencing
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC01061B, CommunicationHangxiang Wang, Wei Chen, Haiyang Xie, Xuyong Wei, Shengyong Yin, Lin Zhou, Xiao Xu, Shusen ZhengWith the increased potential of RNA interference (RNAi) as a therapeutic modality, there is broad interest in the development of biocompatible vehicles for efficient, cell-specific delivery of siRNA agents. To...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - May 12, 2014 Category: Chemistry Authors: Hangxiang Wang Source Type: research

Multivalent comb-type aptamer-siRNA conjugates for efficient and selective intracellular delivery.
In this study, a simple and efficient strategy for selective intracellular delivery of RNA therapeutics into target cancer cells was designed using direct complementary base pairing between chemically conjugated multimeric antisense strands and aptamer-incorporating sense strands. PMID: 24830507 [PubMed - as supplied by publisher]
Source: Chemical Communications - May 16, 2014 Category: Chemistry Authors: Yoo H, Jung H, Kim SA, Mok H Tags: Chem Commun (Camb) Source Type: research

Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C4CC03834G, CommunicationCheol Am Hong, Bora Jang, Eun Hye Jeong, Hansaem Jeong, Hyukjin LeeLarge-scale preparation of DNA nanostructures for siRNA delivery has been achieved by an isothermal enzymatic amplification process.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - June 26, 2014 Category: Chemistry Authors: Cheol Am Hong Source Type: research