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Total 1197 results found since Jan 2013.
Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu,Zn-superoxide dismutase Cell Biology
Cu, Zn superoxide dismutase (SOD1) is one of the genes implicated in the devastating neurodegenerative disorder amyotrophic lateral sclerosis (ALS). Although the precise mechanisms of SOD1 mutant (SOD1mut)-induced motoneuron toxicity are still unclear, defects in SOD1 proteostasis are known to have a critical role in ALS pathogenesis. We previously reported that the SOD1mut adopts a conformation that exposes a Derlin-1–binding region (DBR) and that DBR-exposed SOD1 interacts with Derlin-1, leading to motoneuron death. We also found that an environmental change, i.e. zinc depletion, induces a conformational change in WT S...
Source: Journal of Biological Chemistry - March 5, 2020 Category: Chemistry Authors: Kengo Homma, Hiromitsu Takahashi, Naomi Tsuburaya, Isao Naguro, Takao Fujisawa, Hidenori Ichijo Tags: Molecular Bases of Disease Source Type: research
Dual targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC01848A, CommunicationTaehyung Kim, Hana Hyun, Roun Heo, Keonwook Nam, Kyungjik Yang, Young Min Kim, Yoon Suk Lee, Jae Yoon An, Jae Hyung Park, KI YOUNG CHOI, Young Hoon Roh A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes; rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer specific intracellular delivery,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 25, 2020 Category: Chemistry Authors: Taehyung Kim Source Type: research
Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC01848A, CommunicationTaehyung Kim, Ha Na Hyun, Roun Heo, Keonwook Nam, Kyungjik Yang, Young Min Kim, Yoon Suk Lee, Jae Yoon An, Jae Hyung Park, Ki Young Choi, Young Hoon Roh A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed. The Dual-PSNP showed significantly enhanced cancer-specific intracellular delivery, gene regulation efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this ...
Source: RSC - Chem. Commun. latest articles - May 29, 2020 Category: Chemistry Authors: Taehyung Kim Source Type: research
Corrigendum: Systemic Delivery of Bc12-Targeting siRNA by DNA Nanoparticles Suppresses Cancer Cell Growth.
PMID: 32691956 [PubMed - in process]
Source: Angewandte Chemie - July 22, 2020 Category: Chemistry Authors: Rahman MA, Wang P, Zhao Z, Wang D, Nannapaneni S, Zhang C, Chen Z, Griffith CC, Hurwitz SJ, Chen ZG, Ke Y, Shin DM Tags: Angew Chem Int Ed Engl Source Type: research
Delivery of siRNA by tailored cell-penetrating urea-based foldamers
Chem. Commun., 2021, Accepted Manuscript DOI: 10.1039/D0CC06285E, CommunicationM égane Bornerie, Anaïs Brion, Gilles Guichard, Antoine Kichler, Céline Douat Cell-penetrating foldamers (CPFs) have recently shown promises as efficient and safe nucleic acid delivery systems. However applications of CPFs to siRNA transport remain scarce. Here, we report helical CPFs tailored... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 21, 2020 Category: Chemistry Authors: M égane Bornerie Source Type: research
A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent
Chem. Commun., 2021, Accepted Manuscript DOI: 10.1039/D1CC03497A, CommunicationAltab Shaikh, Praveen Neeli, Gajalakshmi Singuru, Sravya Panangipalli, Raj Kumar Banerjee, M. Sridhar Reddy, Rajamannar Thennati, B. Surendar Reddy, Srigiridhar Kotamraju Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as a functional, and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induce selective breast cancer cell death,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - October 20, 2021 Category: Chemistry Authors: Altab Shaikh Source Type: research
A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery
Chem. Commun., 2022, Accepted Manuscript DOI: 10.1039/D1CC06655B, CommunicationChi Ma, Dandan Zhu, Wenyi Lin, Ying Li, Yuanzheng Huang, Huiling Zhu, Mengyun Ye, Yang Wang, Ling Peng, Xiaoxuan Liu Small interfering RNA (siRNA)-based therapeutics represent a novel and compelling drug modality, provided that safe and competent vectors are available for their delivery. Here, we report a biodegradable amphiphilic poly(aminoester)... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 16, 2022 Category: Chemistry Authors: Chi Ma Source Type: research
Molecules, Vol. 28, Pages 1802: Critical Review on the Different Roles of Exosomes in TNBC and Exosomal-Mediated Delivery of microRNA/siRNA/lncRNA and Drug Targeting Signalling Pathways in Triple-Negative Breast Cancer
This article highlights the significant roles of exosomes associated with TNBC, the involvement of exosomes in breast cancer diagnosis, progression, and the treatment of triple-negative breast cancer by the exosomes as a drug delivery system. This review paper also illustrates the role of exosomes in initiating EMT in breast cancer, including novel signalling.
Source: Molecules - February 14, 2023 Category: Chemistry Authors: Manosi Banerjee Vijayarangan Devi Rajeswari Tags: Review Source Type: research
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex
Chem Commun (Camb). 2023 May 5. doi: 10.1039/d3cc01143g. Online ahead of print.ABSTRACTTo ensure specificity of small interfering RNAs (siRNAs), the antisense strand must be selected by the RNA-induced silencing complex (RISC). We have previously demonstrated that a 5'-morpholino-modified nucleotide at the 5'-end of the sense strand inhibits its interaction with RISC ensuring selection of the desired antisense strand. To improve this antagonizing binding property even further, a new set of morpholino-based analogues, Mo2 and Mo3, and a piperidine analogue, Pip, were designed based on the known structure of Argonaute2, the ...
Source: Chemical Communications - May 5, 2023 Category: Chemistry Authors: Dhrubajyoti Datta Christopher S Theile Kelly Wassarman June Qin Tim Racie Karyn Schmidt Yongfeng Jiang Rachel Sigel Maja M Janas Martin Egli Muthiah Manoharan Source Type: research
