Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC01848A, CommunicationTaehyung Kim, Ha Na Hyun, Roun Heo, Keonwook Nam, Kyungjik Yang, Young Min Kim, Yoon Suk Lee, Jae Yoon An, Jae Hyung Park, Ki Young Choi, Young Hoon Roh A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed. The Dual-PSNP showed significantly enhanced cancer-specific intracellular delivery, gene regulation efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research