Multivalent comb-type aptamer-siRNA conjugates for efficient and selective intracellular delivery.

In this study, a simple and efficient strategy for selective intracellular delivery of RNA therapeutics into target cancer cells was designed using direct complementary base pairing between chemically conjugated multimeric antisense strands and aptamer-incorporating sense strands.
PMID: 24830507 [PubMed - as supplied by publisher]

Source: Chemical Communications - May 16, 2014 Category: Chemistry Authors: Yoo H, Jung H, Kim SA, Mok H Tags: Chem Commun (Camb) Source Type: research