Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells.

Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells. Chem Commun (Camb). 2020 May 28;: Authors: Kim T, Hyun HN, Heo R, Nam K, Yang K, Kim YM, Lee YS, An JY, Park JH, Choi KY, Roh YH Abstract A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands. PMID: 32463029 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research