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Total 19 results found since Jan 2013.
Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment.
Abstract
Metastasis is one of the main reasons causing death in cancer patients. It was reported that chemotherapy might induce metastasis. In order to uncover the mechanism of chemotherapy-induced metastasis and find solutions to inhibit treatment-induced metastasis, the relationship between epithelial-mesenchymal transition (EMT) and doxorubicin (DOX) treatment was investigated and a redox-sensitive small interfering RNA (siRNA) delivery system was designed. DOX-related reactive oxygen species (ROS) were found to be responsible for the invasiveness of tumor cells in vitro, causing enhanced EMT and cytoskeleton r...
Source: J Zhejiang Univ Sci ... - February 29, 2020 Category: Science Authors: Liu X, Zhou XQ, Shang XW, Wang L, Li Y, Yuan H, Hu FQ Tags: J Zhejiang Univ Sci B Source Type: research
Comparative Study of the Effects of Ferrochelatase ‐siRNA Transfection Mediated by Ultrasound Microbubbles and Polyethyleneimine in Combination with Low‐dose ALA to Enhance PpIX Accumulation in Human Endometrial Cancer Xenograft Nude Mice Models
Red fluorescence caused by the accumulation of PpIX in endometrial cancer xenografts in nude mice after high ‐dose ALA injection could be detected easily byin vivo animal imaging system, but low ‐dose ALA (1.0 mg kg−1) was injected into xenografts, there was no red fluorescence of tumor. However, knockdown of FECH in nude mice was performed by transfection with FECH ‐siRNA mediated by PEI and ultrasound microbubbles alone or in combination, then 1.0 mg kg−1 ALA was injected, apparent red fluorescence of the xenografts was observed, and the fluorescence intensity was PEI+ ultrasound microbubbles > PEI...
Source: Photochemistry and Photobiology - July 18, 2019 Category: Science Authors: Xian Zhang,
Longfei Chen,
Lvfen Gao,
Xuesong Gao,
Nan Li,
Yuwei Song,
Xinke Huang,
Shaoqiang Lin,
Xiaoyu Wang Tags: Research Article Source Type: research
MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival Medical Sciences
Oncogenic mutations in the small GTPase KRAS are frequently found in human cancers, and, currently, there are no effective targeted therapies for these tumors. Using a combinatorial siRNA approach, we analyzed a panel of KRAS mutant colorectal and pancreatic cancer cell lines for their dependency on 28 gene nodes that...
Source: Proceedings of the National Academy of Sciences - March 4, 2019 Category: Science Authors: Chih-Shia Lee, Liam C. Lee, Tina L. Yuan, Sirisha Chakka, Christof Fellmann, Scott W. Lowe, Natasha J. Caplen, Frank McCormick, Ji Luo Tags: PNAS Plus Source Type: research
Comparative Study of the Effects of Ferrochelatase ‐siRNA Transfection Mediated by Ultrasound Microbubbles and Polyethyleneimine in Combination with Low‐dose ALA to Enhance PpIX Accumulation in Human Endometrial Cancer Xenograft Nude Mice Models
Red fluorescence caused by the accumulation of PpIX in endometrial cancer xenografts in nude mice after high ‐dose ALA injection could be detected easily byin vivo animal imaging system, but low ‐dose ALA (1.0 mg kg−1) was injected into xenografts, there was no red fluorescence of tumor. However, knockdown of FECH in nude mice was performed by transfection with FECH ‐siRNA mediated by PEI and ultrasound microbubbles alone or in combination, then 1.0 mg kg−1 ALA was injected, apparent red fluorescence of the xenografts was observed, and the fluorescence intensity was PEI+ ultrasound microbubbles > PEI...
Source: Photochemistry and Photobiology - February 11, 2019 Category: Science Authors: Xian Zhang,
Longfei Chen,
Lvfen Gao,
Xuesong Gao,
Nan Li,
Yuwei Song,
Xinke Huang,
Shaoqiang Lin,
Xiaoyu Wang Tags: Research Article Source Type: research
The transcription factor SP3 drives TNF-{alpha} expression in response to Smac mimetics
The controlled production and downstream signaling of the inflammatory cytokine tumor necrosis factor–α (TNF-α) are important for immunity and its anticancer effects. Although chronic stimulation with TNF-α is detrimental to the health of the host in several autoimmune and inflammatory disorders, TNF-α—contrary to what its name implies—leads to cancer formation by promoting cell proliferation and survival. Smac mimetic compounds (SMCs), small-molecule antagonists of inhibitor of apoptosis proteins (IAPs), switch the TNF-α signal from promoting survival to promoting death in c...
Source: Signal Transduction Knowledge Environment - January 29, 2019 Category: Science Authors: Beug, S. T., Cheung, H. H., Sanda, T., St-Jean, M., Beauregard, C. E., Mamady, H., Baird, S. D., LaCasse, E. C., Korneluk, R. G. Tags: STKE Research Articles Source Type: news
Comparative Study of the Effects of FECH ‐siRNA Transfection Mediated by Ultrasound Microbubbles and PEI in Combination with Low‐dose ALA to Enhance PpIX Accumulation in Human Endometrial Cancer Xenograft Nude Mice Models
This article is protected by copyright. All rights reserved.
Source: Photochemistry and Photobiology - December 24, 2018 Category: Science Authors: Xian Zhang,
Longfei Chen,
Lvfen Gao,
Xuesong Gao,
Nan Li,
Yuwei Song,
Xinke Huang,
Shaoqiang Lin,
Xiaoyu Wang Tags: Research Article Source Type: research
CDK12-mediated transcriptional regulation of noncanonical NF-{kappa}B components is essential for signaling
Members of the family of nuclear factor B (NF-B) transcription factors are critical for multiple cellular processes, including regulating innate and adaptive immune responses, cell proliferation, and cell survival. Canonical NF-B complexes are retained in the cytoplasm by the inhibitory protein IBα, whereas noncanonical NF-B complexes are retained by p100. Although activation of canonical NF-B signaling through the IBα kinase complex is well studied, few regulators of the NF-B–inducing kinase (NIK)–dependent processing of noncanonical p100 to p52 and the subsequent nuclear translocation of p52 have ...
Source: Signal Transduction Knowledge Environment - July 31, 2018 Category: Science Authors: Henry, K. L., Kellner, D., Bajrami, B., Anderson, J. E., Beyna, M., Bhisetti, G., Cameron, T., Capacci, A. G., Bertolotti-Ciarlet, A., Feng, J., Gao, B., Hopkins, B., Jenkins, T., Li, K., May-Dracka, T., Murugan, P., Wei, R., Zeng, W., Allaire, N., Buckle Tags: STKE Research Articles Source Type: news
Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling
Lymphatic vessels constitute a specialized vasculature that is involved in development, cancer, obesity, and immune regulation. The migration of lymphatic endothelial cells (LECs) is critical for vessel growth (lymphangiogenesis) and vessel remodeling, processes that modify the lymphatic network in response to developmental or pathological demands. Using the publicly accessible results of our genome-wide siRNA screen, we characterized the migratome of primary human LECs and identified individual genes and signaling pathways that regulate LEC migration. We compared our data set with mRNA differential expression data from en...
Source: Signal Transduction Knowledge Environment - October 3, 2017 Category: Science Authors: Williams, S. P., Odell, A. F., Karnezis, T., Farnsworth, R. H., Gould, C. M., Li, J., Paquet-Fifield, S., Harris, N. C., Walter, A., Gregory, J. L., Lamont, S. F., Liu, R., Takano, E. A., Nowell, C. J., Bower, N. I., Resnick, D., Smyth, G. K., Coultas, L. Tags: STKE Research Articles Source Type: news
Biodegradable and Bioreducible Poly(beta ‐amino ester) Nanoparticles for Intracellular Delivery to Treat Brain Cancer
This article is protected by copyright. All rights reserved.
Source: AIChE Journal - February 28, 2017 Category: Science Authors: Yuan Rui, Gabriella Qui ñones, Jordan J. Green Tags: perspective Source Type: research
Selective NP delivery to cancer over normal cells Engineering
Conventional chemotherapeutics nonselectively kill all rapidly dividing cells, which produces numerous side effects. To address this challenge, we report the discovery of functional polyesters that are capable of delivering siRNA drugs selectively to lung cancer cells and not to normal lung cells. Selective polyplex nanoparticles (NPs) were identified by high-throughput...
Source: Proceedings of the National Academy of Sciences - September 26, 2016 Category: Science Authors: Yan, Y., Liu, L., Xiong, H., Miller, J. B., Zhou, K., Kos, P., Huffman, K. E., Elkassih, S., Norman, J. W., Carstens, R., Kim, J., Minna, J. D., Siegwart, D. J. Tags: PNAS Plus Source Type: research
NIR nanoparticles for imaging and siRNA delivery Medical Sciences
Anaplastic thyroid cancer (ATC), one of the most aggressive solid tumors, is characterized by rapid tumor growth and severe metastasis to other organs. Owing to the lack of effective treatment options, ATC has a mortality rate of ∼100% and median survival of less than 5 months. RNAi nanotechnology represents a...
Source: Proceedings of the National Academy of Sciences - July 11, 2016 Category: Science Authors: Liu, Y., Gunda, V., Zhu, X., Xu, X., Wu, J., Askhatova, D., Farokhzad, O. C., Parangi, S., Shi, J. Tags: Physical Sciences Source Type: research
PHB1 siRNA nanoparticles for cancer treatment Engineering
RNA interference (RNAi) represents a promising strategy for identification and validation of putative therapeutic targets and for treatment of a myriad of important human diseases including cancer. However, the effective systemic in vivo delivery of small interfering RNA (siRNA) to tumors remains a formidable challenge. Using a robust self-assembly strategy,...
Source: Proceedings of the National Academy of Sciences - June 23, 2015 Category: Science Authors: Zhu, X., Xu, Y., Solis, L. M., Tao, W., Wang, L., Behrens, C., Xu, X., Zhao, L., Liu, D., Wu, J., Zhang, N., Wistuba, I. I., Farokhzad, O. C., Zetter, B. R., Shi, J. Tags: Biological Sciences Source Type: research
siRNA-toting nanoparticles inhibit breast cancer metastasis
Researchers combined finely crafted nanoparticles with one of nature's potent disrupters to prevent the spread of triple-negative breast cancer in mouse models. The researchers are working toward clinical trials and exploring use of the technology for other cancers and diseases.
Source: ScienceDaily Headlines - May 12, 2015 Category: Science Source Type: news
The reverse transcriptase–RNase H: from viruses to antiviral defense
Ubiquitous, reverse transcriptase may have contributed to the transition from the RNA to the DNA world, a transition that also involved RNase H–like activities. Both enzymes shaped various genomes and antiviral defense systems as endogenous retroviruses (ERVs) and transposable elements (TEs). A close relationship between a dozen components of retroviruses and the small interfering RNA (siRNA) antiviral‐defense machinery has been characterized. Most antiviral‐defense systems involve RNase H–like enzymes destroying invading nucleic acids, RNA, or DNA. Such enzymes include RNases H, Argonaute, Dicer, Cas9, transposase...
Source: Annals of the New York Academy of Sciences - February 19, 2015 Category: Science Authors: Karin Moelling, Felix Broecker Tags: Original Article Source Type: research
Correlating animal and human data with CALAA-01 Medical Sciences
Nanoparticle-based experimental therapeutics are currently being investigated in numerous human clinical trials. CALAA-01 is a targeted, polymer-based nanoparticle containing small interfering RNA (siRNA) and, to our knowledge, was the first RNA interference (RNAi)–based, experimental therapeutic to be administered to cancer patients. Here, we report the results from the initial phase...
Source: Proceedings of the National Academy of Sciences - August 5, 2014 Category: Science Authors: Zuckerman, J. E., Gritli, I., Tolcher, A., Heidel, J. D., Lim, D., Morgan, R., Chmielowski, B., Ribas, A., Davis, M. E., Yen, Y. Tags: Biological Sciences Source Type: research
