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Differential expression of estrogen receptor subtypes in ovarian high-grade serous carcinoma and clear cell carcinoma
CONCLUSIONS: High GPER-1 expression is an independent prognostic factor for PFS in HGSC patients, and GPER-1 may play a role in HGSC cell proliferation.PMID:34646075 | PMC:PMC8499597 | DOI:10.1002/rmb2.12402
Source: Reproductive Biology - October 14, 2021 Category: Reproduction Medicine Authors: Daiken Osaku Tetsuro Oishi Naoshi Kawamura Yuki Iida Hiroaki Komatsu Akiko Kudoh Jun Chikumi Shinya Sato Tasuku Harada Source Type: research

MiR-126-3p inhibits ovarian cancer proliferation and invasion via targeting PLXNB2.
Abstract Ovarian cancer is one of the leading malignancies in women and the 5-year survival rate of ovarian cancer still remains poor. In the present study, we aimed to investigate the interaction between the miR-126-3p and PLXNB2 in the progression of ovarian cancer. The qRT-PCR data revealed a reduction of miR-126-3p level in ovarian cancer tissues comparing to the adjacent normal tissues. Over-expression of miR-126-3p in ovarian cancer cells suppressed cell proliferation and invasion and the phosphorylation of AKT and ERK1/2. The cell cycle assay results showed that the over-expression of miR-126-3p induced cel...
Source: Reproductive Biology - July 24, 2018 Category: Reproduction Medicine Authors: Xiang G, Cheng Y Tags: Reprod Biol Source Type: research

Elevated phosphatase of regenerating liver 3 (PRL-3) promotes cytoskeleton reorganization, cell migration and invasion in endometrial stromal cells from endometrioma
STUDY QUESTION Is phosphatase of regenerating liver-3 (PRL-3) associated with increased motility of endometriotic cells from endometrioma? SUMMARY ANSWER Elevated PRL-3 promotes cytoskeleton reorganization, cell migration and invasion of endometrial stromal cells (ESCs) from endometrioma. WHAT IS KNOWN ALREADY Overexpression of PRL-3 is associated with cancer cell migration, invasion and metastatic phenotype. STUDY DESIGN, SIZE, DURATION Primary human ESCs were isolated from eutopic endometrium of women without endometriosis (EuCo, n = 10), with histologically proven endometrioma (EuEM, n = 19) and from the cyst wall of...
Source: Human Reproduction - March 15, 2016 Category: Reproduction Medicine Authors: Zhan, H., Ma, J., Ruan, F., Bedaiwy, M. A., Peng, B., Wu, R., Lin, J. Tags: Gynaecology Source Type: research

Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice.
Abstract Women with endometriosis can suffer from decreased fecundity or complete infertility via abnormal oocyte function or impaired placental-uterine interactions required for normal pregnancy establishment and maintenance. Although AT-rich interactive domain 1A (SWI-like) (ARID1A) is a putative tumor suppressor in human endometrial cancers and endometriosis-associated ovarian cancers, little is known about its role in normal uterine function. To study the potential function of ARID1A in the female reproductive tract, we generated mice with a conditional knockout of Arid1a using anti-Müllerian hormone receptor...
Source: Biology of Reproduction - March 9, 2016 Category: Reproduction Medicine Authors: Wang X, Khatri S, Broaddus R, Wang Z, Hawkins SM Tags: Biol Reprod Source Type: research