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Specialty: Internal Medicine
Cancer: Liver Cancer
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Total 18 results found since Jan 2013.
The effect of Epitranscriptomic writer (METTL3) silencing on Hepatocellular carcinoma cell line
ConclusionsKnockdown ofMETTL3 in HepG2 cell lines successively reduced cell viability and active proliferative cell count.METTL3 may be involved in liver tumorigenesis and its targeting may be of therapeutic benefit.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
Evaluation of the Consequence of CTNNB1 & amp; RAB1A Targeting on Hepatocellular Carcinoma Cell Line
ConclusionTargetingCTNNB1or RAB1A in HepG2 cell lines decreased the cell viability and proliferative activity. Moreover, targetingCTNNB1 was effective in decreasing cell proliferative activity compared to targetingRAB1A in HepG2 cell lines. So, targeting CTNNB1 may have a potential therapeutic effect in treatment of HCC.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the β-catenin pathway
CONCLUSION: DHX32 was an attractive regulator of HCC progression and indicated DHX32 canserve as a potential biomarker and therapeutic target for HCC patients.PMID:33729094 | DOI:10.1080/07853890.2021.1898674
Source: Annals of Medicine - March 17, 2021 Category: Internal Medicine Authors: Xiaoyun Hu Guosheng Yuan Qi Li Jing Huang Xiao Cheng Jinzhang Chen Source Type: research
Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma.
CONCLUSIONS: Heat stress induced protective autophagy against heat-induced apoptosis in HCC via the ATP-AMPK-mTOR axis, suggesting that targeting autophagy may be a promising strategy for improving the efficacy of RFA treatment for HCC.
PMID: 31007109 [PubMed - as supplied by publisher]
Source: International Journal of Hyperthermia - April 24, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC
Conclusion AATF drives NAFLD and hepatocarcinogenesis, offering a potential target for therapeutic intervention.This article is protected by copyright. All rights reserved.
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Divya P. Kumar,
Prasanna K. Santhekadur,
Mulugeta Seneshaw,
Faridoddin Mirshahi,
Cora Uram Tuculescu,
Arun J. Sanyal Tags: Original Article Source Type: research
Polo ‐like‐kinase 1 is a proviral host factor for hepatitis B virus replication
Conclusion: PLK1 is a proviral host factor that could be envisaged as a target for combined antiviral and antitumoral strategies against HBV infection and HBV‐mediated carcinogenesis. (Hepatology 2017).
Source: Hepatology - November 6, 2017 Category: Internal Medicine Authors: Ahmed Diab, Adrien Foca, Floriane Fusil, Thomas Lahlali, Pascal Jalaguier, Fouzia Amirache, Lia N'Guyen, Nathalie Isorce, Fran çois‐Loïc Cosset, Fabien Zoulim, Ourania Andrisani, David Durantel Tags: Viral Hepatitis Source Type: research
Circular RNA MTO1 acts as the sponge of miR ‐9 to suppress hepatocellular carcinoma progression
Conclusion: circMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR‐9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment. The decrease of circMTO1 in HCC tissues may serve as a prognosis predictor for poor survival of patients. This article is protected by copyright. All rights reserved.
Source: Hepatology - May 18, 2017 Category: Internal Medicine Authors: Dan Han, Jiangxue Li, Huamin Wang, Xiaoping Su, Jin Hou, Yan Gu, Cheng Qian, Yun Lin, Xiang Liu, Mingyan Huang, Nan Li, Weiping Zhou, Yizhi Yu, Xuetao Cao Tags: Hepatobiliary Malignancies Source Type: research
STAT5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression
CONCLUSIONS: STAT5 plays an important role in hepatic fat metabolism through regulation of CD36, and is a potential therapeutic candidate for liver steatosis.
Source: Hepatology Research - August 31, 2016 Category: Internal Medicine Authors: Atsushi Hosui, Tomohide Tatsumi, Hayato Hikita, Yoshinobu Saito, Naoki Hiramatsu, Masahiko Tsujii, Lothar Hennighausen, Tetsuo Takehara Tags: Original Article Source Type: research
Theranostical nanosystem‐mediated identification of an oncogene and highly effective therapy in hepatocellular carcinoma
In conclusion, the theranostic siRNA nanomedicine examined here possesses great theranostic potential for combined gene therapy and MRI diagnosis of HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology - December 1, 2015 Category: Internal Medicine Authors: Yu Guo, Jing Wang, Lu Zhang, Shunli Shen, Ruomi Guo, Yang Yang, Wenjie Chen, Yiru Wang, Guihua Chen, Xintao Shuai Tags: Hepatobiliary Malignancies Source Type: research
Fibroblast growth factor receptor 3 isoforms: novel therapeutic targets for hepatocellular carcinoma?
Conclusions. Deregulated FGFR3 variants exhibit specific effects in the malignant progression of HCC cells. Accordingly, blockade of FGFR3‐mediated signaling may be a promising therapeutic approach to antagonize growth and malignant behavior of HCC cells. This article is protected by copyright. All rights reserved.
Source: Hepatology - August 1, 2015 Category: Internal Medicine Authors: Jakob Paur, Lisa Nika, Christiane Maier, Alexander Moscu‐Gregor, Julia Kostka, Daniela Huber, Thomas Mohr, Petra Heffeter, Waltraud C. Schrottmaier, Sonja Kappel, Daniela Kandioler, Klaus Holzmann, Brigitte Marian, Walter Berger, Michael Grusch, Bettina Tags: Hepatobiliary Malignancies Source Type: research
Mineralocorticoid receptor suppresses cancer progression and Warburg effect by modulating miR‐338‐3p‐PKLR axis in hepatocellular carcinoma
Conclusion: The present study reveals a novel role of MR in HCC development by modulating miR‐338‐3p‐PKLR axis with an ability to suppress the Warburg effect. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 1, 2015 Category: Internal Medicine Authors: Huizhen Nie, Jun Li, Xiao‐Mei Yang, Qing‐Zhen Cao, Ming‐Xuan Feng, Feng Xue, Lin Wei, Wenxin Qin, Jianren Gu, Qiang Xia, Zhi‐Gang Zhang Tags: Hepatobiliary Malignancies Source Type: research
MiR‐486 regulates metastasis and chemosensitivity in hepatocellular carcinoma by targeting CLDN10 and CITRON
ConclusionsOur data indicated that miR‐486 may function as a novel tumor suppressor in HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - February 5, 2015 Category: Internal Medicine Authors: Huiyan Sun, Chunping Cui, Fengjun Xiao, Hua Wang, Jun Xu, Xuefeng Shi, Yuefeng Yang, Qunwei Zhang, Xiaofei Zheng, Xiaoming Yang, Chutse Wu, Lisheng Wang Tags: Original Article Source Type: research
Livin is associated with the invasive and oncogenic phenotypes of human hepatocellular carcinoma cells
ConclusionThese results suggest that Livin is associated with invasive and oncogenic phenotypes of human HCC cells.
Source: Hepatology Research - July 22, 2014 Category: Internal Medicine Authors: Sung‐Bum Cho, Wan‐Sik Lee, Young‐Lan Park, Nuri Kim, Hyung‐Hoon Oh, Mi‐Young Kim, Chan‐Young Oak, Cho‐Yun Chung, Hyung‐Chul Park, Jong‐Sun Kim, Dae‐Seong Myung, Sang‐Hoon Kim, Kyung‐Hwa Lee, Sung‐Kyu Choi, Young‐Eun Joo Tags: Original Article Source Type: research
RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma
Conclusion: DUSP21 plays an important role in sustaining HCC cell proliferation and may thus act as a potential therapeutic target in HCC treatment. (Hepatology 2013;)
Source: Hepatology - December 18, 2013 Category: Internal Medicine Authors: Qing Deng, Kun‐Yu Li, Hui Chen, Ji‐Hong Dai, Yang‐Yang Zhai, Qun Wang, Niu Li, Yu‐Ping Wang, Ze‐Guang Han Tags: Hepatobiliary Malignancies Source Type: research
MicroRNA‐140‐5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma
Conclusion: These data elucidated a tumor suppressor role for miR‐140‐5p in HCC development and progression with therapeutic potential. Our correlation studies in clinical HCC samples further suggest that miR‐140‐5p could be a valuable biomarker for HCC prognosis. (Hepatology 2013 )
Source: Hepatology - May 14, 2013 Category: Internal Medicine Authors: Hao Yang, Feng Fang, Ruimin Chang, Lianyue Yang Tags: Hepatobiliary Malignancies Source Type: research
