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A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RAR α pathway in Chinese individuals
ConclusionsAnHUWE1 promoter SNP significantly downregulates its expression in NOA patients. Mechanistically, HUWE1 regulates germ cell differentiation during meiotic prophase through its participation in RA/RAR α signaling and subsequent modulation of γH2AX. Taken together, these results strongly suggest that the genetic polymorphisms ofHUWE1 are closely related to spermatogenesis and NOA pathogenesis.This article is protected by copyright. All rights reserved
Source: Andrology - June 8, 2023 Category: Urology & Nephrology Authors: Xudong Shan, Xueguang Zhang, Gelin Huang, Jiao Lv, Zixia Ye, Chuan Jiang, Xiaohui Jiang, Jianxing Cheng, Haocheng Lin, Hui Jiang, Huanxun Yue, Zhengrong Wang, Wenming Xu Tags: ORIGINAL ARTICLE Source Type: research

The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia
Conclusions: We highlight prominent MAEL expression in the intra-testicular spermatid and the mitochondria of ejaculated spermatozoa. MAEL directly binds toGPX4 andUBL4B, and loss of MAEL induces mitochondrial dysfunction. MAEL-mitochondrial function-motility relationship might advance our understanding of the causes of asthenozoospermia.This article is protected by copyright. All rights reserved
Source: Andrology - February 14, 2023 Category: Urology & Nephrology Authors: Yu ‐Sheng Cheng, Hsing‐Yi Chen, Yu‐Chiao Lin, Yi‐Syuan Lin, Yi‐Chun Yeh, Yi‐Hsuan Yeh, Yung‐Hsuan Cheng, Yung‐Ming Lin, Han‐Yu Weng, Tsung‐Yen Lin, Shih‐Chieh Lin Tags: ORIGINAL ARTICLE Source Type: research

TGF ‐β3 induces lactate production in Sertoli cell through inhibiting the Notch pathway
ConclusionTGF- β3 induces lactate production in SC through up-regulating Lgl2, which weakened the Notch signaling activity and intensified glycolysis in SCs. Thus, besides the known function of TGF-β3 as the BTB regulator, TGF-β3-Lgl2-Notch may be considered an important pathway controlling SC glycolysis and sp ermatogenesis.
Source: Andrology - September 13, 2022 Category: Urology & Nephrology Authors: Ying Xu, Shuyi Jiang, Ying Hu, Qiang Zhang, Wenhui Su Tags: ORIGINAL ARTICLE Source Type: research

Low androgen status inhibits erectile function by upregulating the expression of proteins of mitochondria ‐associated membranes in rat corpus cavernosum
ConclusionLow androgen status upregulated the expressions of patients in MAMs (FACL-4, PACS-2, and IP3R1) in the corpus cavernosum  and inhibited the eNOS/NO/cGMP signaling pathway, resulting in impaired erectile function in rats. Erectile function may be improved by inhibiting the high expression of PACS-2 in the corpus cavernosum under low androgen state.
Source: Andrology - May 2, 2022 Category: Urology & Nephrology Authors: Hao ‐Zhou Yang, Wen‐ju Xiong, Xiong Li, Jun Jiang, Rui Jiang Tags: ORIGINAL ARTICLE Source Type: research

Low androgen status inhibits erectile function by up ‐regulating the expression of proteins of mitochondria‐associated membranes in rat corpus cavernosum
ConclusionLow androgen status up-regulated the expressions of patients in MAMs (FACL-4, PACS-2 and IP3R1) in the corpus cavernosum  and inhibited the eNOS/NO/cGMP signaling pathway, resulting in impaired erectile function in rats. Erectile function may be improved by inhibiting the high expression of PACS-2 in the corpus cavernosum under low androgen state.This article is protected by copyright. All rights reserved
Source: Andrology - April 25, 2022 Category: Urology & Nephrology Authors: Hao ‐Zhou Yang, Wen‐ju Xiong, Xiong Li, Jun Jiang, Rui Jiang Tags: ORIGINAL ARTICLE Source Type: research

‘Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway’
ConclusionsThis is the first evidence that SNAI1 and SNAI2 are involved in human spermatogenesis, with independent functions. These outcomes demonstrate that SNAI1 and SNAI2 inhibition leads to loss of migratory and viability capacities in seminoma cells. These findings show the potential for therapeutic treatments targeting SNAIL or BMP4 signalling for patients with metastatic testicular germ cell tumours.
Source: Andrology - June 11, 2020 Category: Urology & Nephrology Authors: Diana J. Micati, Karthika Radhakrishnan, Julia C. Young, Ewa Rajpert ‐De Meyts, Gary R. Hime, Helen E. Abud, Kate L. Loveland Tags: ORIGINAL ARTICLE Source Type: research

Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway
ConclusionsThis is the first evidence that SNAI1 and SNAI2 are involved in human spermatogenesis, with independent functions. These outcomes demonstrate that SNAI1 and SNAI2 inhibition leads to loss of migratory and viability capacities in seminoma cells. These findings show the potential for therapeutic treatments targeting SNAIL or BMP4 signalling for patients with metastatic testicular germ cell tumours.
Source: Andrology - May 21, 2020 Category: Urology & Nephrology Authors: Diana J. Micati, Karthika Radhakrishnan, Julia C. Young, Ewa Rajpert ‐De Meyts, Gary R. Hime, Helen E. Abud, Kate L. Loveland Tags: ORIGINAL ARTICLE Source Type: research

Cholesterol accumulation, lipid droplet formation, and steroid production in Leydig cells: Role of translocator protein (18 ‐kDa)
ConclusionThese results support the conclusion that FGIN ‐1‐27 stimulates steroid formation by increasing TSPO‐mediated cholesterol translocation into the inner mitochondria for steroidogenesis, as well as into the cytosol for lipid droplet formation. FGIN‐1‐27 also increased steroid formation at least in part by inducing the conversion of chole steryl ester located in lipid droplets to cholesterol, thus making available more substrate for steroid formation.
Source: Andrology - December 8, 2019 Category: Urology & Nephrology Authors: Jin ‐Yong Chung, Haolin Chen, Vassilios Papadopoulos, Barry Zirkin Tags: ORIGINAL ARTICLE Source Type: research

Cholesterol Accumulation, Lipid Droplet Formation and Steroid Production in Leydig Cells: Role of Translocator Protein (18 ‐kDa)
ConclusionThese results support the conclusion that FGIN ‐1‐27 stimulates steroid formation by increasing TSPO‐mediated cholesterol translocation into the inner mitochondria for steroidogenesis, as well as into the cytosol for lipid droplet formation. FGIN‐1‐27 also increased steroid formation at least in part by inducing the conversion of chole steryl ester located in lipid droplets to cholesterol, thus making available more substrate for steroid formation.
Source: Andrology - November 17, 2019 Category: Urology & Nephrology Authors: Jin ‐Yong Chung, Haolin Chen, Vassilios Papadopoulos, Barry Zirkin Tags: ORIGINAL ARTICLE Source Type: research

Preconditioning of adipose ‐derived stem cells by phosphodiesterase‐5 inhibition enhances therapeutic efficacy against diabetes‐induced erectile dysfunction
ConclusionsAdipose ‐derived stem cell therapy could serve as an alternate approach for diabetes‐induced erectile dysfunction, albeit with a long onset period.In vitro preconditioning of adipose ‐derived stem cells could accelerate the functional and structural recoveryin vivo, indicating that preconditioning by inhibition of phosphodiesterase type 5 may improve adipose ‐derived stem cells therapy following diabetes‐induced erectile dysfunction.
Source: Andrology - June 18, 2019 Category: Urology & Nephrology Authors: J. Yang, Z. Yu, Y. Zhang, G. ‐H. Zang, L. Zhuan, Z. Tang, Y. Liu, T. Wang, S.‐G. Wang, J.‐H. Liu Tags: Original Article Source Type: research

Leydig cells contribute to the inhibition of spermatogonial differentiation after irradiation of the rat
Summary Irradiation with 6 Gy produces a complete block of spermatogonial differentiation in LBNF1 rats that would be permanent without treatment. Subsequent suppression of gonadotropins and testosterone (T) restores differentiation to the spermatocyte stage; however, this process requires 6 weeks. We evaluated the role of Leydig cells (LCs) in maintenance of the block in spermatogonial differentiation after exposure to radiation by specifically eliminating functional LCs with ethane dimethane sulfonate (EDS). EDS (but not another alkylating agent), given at 10 weeks after irradiation, induced spermatogonial differentia...
Source: Andrology - March 1, 2016 Category: Urology & Nephrology Authors: G. Shetty, W. Zhou, C. C. Y. Weng, S. H. Shao, M. L. Meistrich Tags: Original Article Source Type: research

Relaxin affects cell organization and early and late stages of spermatogenesis in a coculture of rat testicular cells
In this study, we investigated a role of relaxin in spermatogenesis, using a short‐term culture of testicular cells of the rat that allowed differentiation of spermatogonia to spermatids. Sertoli, germ, and peritubular myoid cells were the predominant cell types in the culture. Sertoli and germ cells expressed RXFP1. Cultures were incubated without (control) or with 0.5% fetal bovine serum (FBS) or 100 ng/mL H2 relaxin (RLN) for 2 days. Cell organization, number, and differentiation were analyzed after 2 (D2), 5 (D5) or 8 (D8) days of culturing. Although the proportion of germ cells decayed from D2 to D5, the relative ...
Source: Andrology - May 1, 2015 Category: Urology & Nephrology Authors: M. T. Pimenta, R. A. R. Francisco, R. P. Silva, C. S. Porto, M. F. M. Lazari Tags: Original Article Source Type: research