A novel SNP in HUWE1 promoter confers increased risk of NOA by affecting the RA/RAR α pathway in Chinese individuals

ConclusionsAnHUWE1 promoter SNP significantly downregulates its expression in NOA patients. Mechanistically, HUWE1 regulates germ cell differentiation during meiotic prophase through its participation in RA/RAR α signaling and subsequent modulation of γH2AX. Taken together, these results strongly suggest that the genetic polymorphisms ofHUWE1 are closely related to spermatogenesis and NOA pathogenesis.This article is protected by copyright. All rights reserved

Source: Andrology - June 8, 2023 Category: Urology & Nephrology Authors: Xudong Shan, Xueguang Zhang, Gelin Huang, Jiao Lv, Zixia Ye, Chuan Jiang, Xiaohui Jiang, Jianxing Cheng, Haocheng Lin, Hui Jiang, Huanxun Yue, Zhengrong Wang, Wenming Xu Tags: ORIGINAL ARTICLE Source Type: research