The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia

Conclusions: We highlight prominent MAEL expression in the intra-testicular spermatid and the mitochondria of ejaculated spermatozoa. MAEL directly binds toGPX4 andUBL4B, and loss of MAEL induces mitochondrial dysfunction. MAEL-mitochondrial function-motility relationship might advance our understanding of the causes of asthenozoospermia.This article is protected by copyright. All rights reserved

Source: Andrology - February 14, 2023 Category: Urology & Nephrology Authors: Yu ‐Sheng Cheng, Hsing‐Yi Chen, Yu‐Chiao Lin, Yi‐Syuan Lin, Yi‐Chun Yeh, Yi‐Hsuan Yeh, Yung‐Hsuan Cheng, Yung‐Ming Lin, Han‐Yu Weng, Tsung‐Yen Lin, Shih‐Chieh Lin Tags: ORIGINAL ARTICLE Source Type: research