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Specialty: Surgery
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Total 76 results found since Jan 2013.
Blockage of CXCR2 suppresses tumor growth of intrahepatic cholangiocellular carcinoma
Conclusion: Our results demonstrated that blocking CXCR2 clearly suppressed the development of ICC. Blocking CXCR2 may be a promising therapeutic approach for ICC.
Source: Surgery - January 6, 2014 Category: Surgery Authors: Hideaki Sueoka, Tadamichi Hirano, Yugo Uda, Yuji Iimuro, Junichi Yamanaka, Jiro Fujimoto Tags: Original Communications Source Type: research
Knockdown of β-catenin expression inhibits neuroblastoma cell growth in vitro and in vivo
Conclusion: β-Catenin knockdown could effectively control growth of neuroblastoma cells in vitro and in nude mice, suggesting that targeting β-catenin may be useful in clinical control of neuroblastoma.
Source: Journal of Pediatric Surgery - December 1, 2013 Category: Surgery Authors: Wei Yao, Kai Li, Shan Zheng, Xianmin Xiao, Yangyang Ma, Xiaowen Zhai Tags: PAPS Papers Source Type: research
Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts
Conclusion: These data might be used along with other markers to predict response to radiation in patients with rectal cancer.
Source: Surgery - August 1, 2013 Category: Surgery Authors: Sergio Huerta, Xiaohuan Gao, Sean Dineen, Payal Kapur, Debrabata Saha, Jeffrey Meyer Tags: Society of University Surgeons Source Type: research
Integrin β1 is critical for gastrin-releasing peptide receptor-mediated neuroblastoma cell migration and invasion
Conclusion: GRP/GRP-R signaling contributes to neuroblastoma cell migration and invasion. Moreover, the integrin ß1 subunit critically regulates GRP-R–mediated neuroblastoma cell migration and invasion.
Source: Surgery - August 1, 2013 Category: Surgery Authors: Sora Lee, Jingbo Qiao, Pritha Paul, Dai H. Chung Tags: Society of University Surgeons Source Type: research
Murine portal vein catheterization to analyze liver-directed therapies
Conclusions: Liver-directed therapy can provide the selective delivery of siRNA to CRC metastases. EpCAM expression in CRC, but not normal liver, could further selectively target hepatic metastases of epithelial origin.
Source: Journal of Surgical Research - July 18, 2013 Category: Surgery Authors: Joseph D. Valentino, Piotr G. Rychahou, W. Conan Mustain, Victoria A. Elliott, B. Mark Evers Tags: Oncology/Endocrine Source Type: research
Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth
Conclusions: Silencing GRP78 not only inhibits tumor, but also decreases the expression of VEGF and VEGFR2. Collectively, therapy targeting for GRP78 may inhibit the formation of colon cancer tumors via the HIF-1α/VEGF/VEGFR2 pathway.
Source: Journal of Surgical Research - May 30, 2013 Category: Surgery Authors: Li-Jen Kuo, Chin-Sheng Hung, Wei-Yu Chen, Yu-Jia Chang, Po-Li Wei Tags: Oncology/Endocrine Source Type: research
Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells
Conclusions: MiR-21 is induced by hypoxia in pancreatic cancer cells via HIF-1α upregulation. MiR-21 overexpression allows cells to avoid apoptosis in a hypoxic microenvironment. Inhibition of miR-21 expression may increase cellular susceptibility to hypoxia in pancreatic cancer.
Source: Journal of Surgical Research - May 20, 2013 Category: Surgery Authors: Thomas A. Mace, Amy L. Collins, Sylwia E. Wojcik, Carlo M. Croce, Gregory B. Lesinski, Mark Bloomston Tags: Gastrointestinal Source Type: research
Involvement of down-regulated E2F3 in Hirschsprung's disease
Conclusions: This is the first study showing the down-regulation of E2F3 in HSCR, bringing new insight to the mechanism of the impaired migration of neural crest cells.
Source: Journal of Pediatric Surgery - April 1, 2013 Category: Surgery Authors: Weibing Tang, Junwei Tang, Jingjing Qin, Qiming Geng, Zhigang Zhou, Bo Li, Jie Zhang, Huan Chen, Yankai Xia, Xinru Wang Tags: Original Articles Source Type: research
Chitosan nanoparticle carrying small interfering RNA to platelet-derived growth factor B mRNA inhibits proliferation of smooth muscle cells in rabbit injured arteries.
In conclusion, transfection of chitosan nanoparticle carrying siRNA against PDGF-B mRNA could inhibit proliferation of vSMCs in the rabbit iliac artery injury model.
PMID: 23518855 [PubMed - as supplied by publisher]
Source: Vascular - March 21, 2013 Category: Surgery Authors: Xia H, Jun J, Wen-Ping L, Yi-Feng P, Xiao-Ling C Tags: Vascular Source Type: research
Therapeutic Implications of MSC-mediated Delivery of SiRNA Via Gap Junctions in the Treatment of Colon Cancer
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: K. Chang, S. Kosari, J. Karas, T. Gregg, P. Brink, R. Bergamaschi Tags: Quickshot Session: Thursday 2/7 3:30 PM to 5:30 PM Source Type: research
SiRNA Transfection With Cholesterol Modification From Electrospun PET Facilitates Gene Silencing in Human Aortic Smooth Muscle Cells
Anastomotic intimal hyperplasia (AIH) remains the leading cause for prosthetic arterial graft failure. RNAi is a promising tool to silence genes such as Thrombospondin-2 (TSP-2), previously shown by our group to be upregulated in AIH. The present study is aimed at delivering modified TSP-2 siRNA (3’cholesterol tagged TSP-2 siRNA) from electrospun polyethylene terephthalate (ePET) and therefore knocking down TSP-2 gene and ultimately inhibiting AIH.
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: M.C. Chun, H.S. Oliver-Allen, C.S. Nabzdyk, S.G. Pathan, M.D. Phaneuf, L. Pradhan-Nabzdyk, F.W. LoGerfo Tags: Oral Session: Thursday 2/7 7:30 AM to 9:30 AM Source Type: research
Effective Intraluminal Delivery of TSP-2 SiRNA to Reduce Intimal Hyperplasia in a Rat Model
Intimal hyperplasia represents a complex pathologic vascular response to injury. Our group previously identified several candidate genes associated with this response. Following implantation of interpositional prosthetic grafts in canine carotid arteries, thrombospondin-2 (TSP-2) was consistently found to be upregulated in the intimal hyperplastic lesion occurring at the anastomosis at 7-, 14-, and 30-day periods. Thus, we sought to determine whether silencing of this gene could attenuate the response to injury and reduce neointima formation in an in vivo model.
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: W.B. Pratt, J.D. Glaser, M.A. Contreras, L. Pradhan-Nabzdyk, F.W. LoGerfo Tags: Oral Session: Thursday 2/7 7:30 AM to 9:30 AM Source Type: research
SiRNA Transfection with Cholesterol Modification from Electrospun PET Facilitates Gene Silencing in Human Aortic Smooth Muscle Cells
Anastomotic intimal hyperplasia (AIH) remains the leading cause for prosthetic arterial graft failure. RNAi is a promising tool to silence genes such as Thrombospondin-2 (TSP-2), previously shown by our group to be upregulated in AIH. The present study is aimed at delivering modified TSP-2 siRNA (3’cholesterol tagged TSP-2 siRNA) from electrospun polyethylene terephthalate (ePET) and therefore knocking down TSP-2 gene and ultimately inhibiting AIH.
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: M.C. Chun, H.S. Oliver-Allen, C.S. Nabzdyk, S.G. Pathan, M.D. Phaneuf, L. Pradhan-Nabzdyk, F.W. LoGerfo Source Type: research
Naked caspase 3 small interfering RNA is effective in cold preservation but not in autotransplantation of porcine kidneys
Conclusions: Naked caspase 3 siRNA administered into the kidney was effective in cold preservation but not enough to protect posttransplant kidneys, which might be because of systemic complementary responses overcoming local effects.
Source: Journal of Surgical Research - July 27, 2012 Category: Surgery Authors: Cheng Yang, Yichen Jia, Tian Zhao, Yinjia Xue, Zitong Zhao, Junlin Zhang, Jina Wang, Xuanchuan Wang, Yongyin Qiu, Miao Lin, Dong Zhu, Guisheng Qi, Yue Qiu, Qunye Tang, Ruiming Rong, Ming Xu, Sujie Ni, Bin Lai, Michael L. Nicholson, Tongyu Zhu, Bin Yang Tags: Transplantation/Immunology Source Type: research
