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Cancer: Gastric (Stomach) Cancer

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Total 32 results found since Jan 2013.

miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1
CONCLUSION: miRNA-149 inhibits the biological behavior of gastric cancer by targeting FOXC1, providing a promising target in the treatment of human gastric cancer.PMID:34957298 | PMC:PMC8709748 | DOI:10.1155/2021/1503403
Source: Biomed Res - December 27, 2021 Category: Research Authors: Dan Li Yunqing Zhang Yulong Li Xiaofei Wang Fenghui Wang Juan Du Huahua Zhang Haiyan Shi Yanfeng Wang Yi Gao Yun Feng Jing Yan Yajuan Xue Yang Yang Jing Zhang Source Type: research

BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation
This study aimed to explore the expression of BOP1 in GC and its potential mechanisms in regulating GC growth, and the relationship between BOP1 level in cancer tissues and survival was also analyzed. The expression of BOP1 was examined by immunohistochemistry (IHC) in a cohort containing 387 patients with primary GC. Cultured GC cells were treated by siRNA to knock down the BOP1 expression, and examined by CCK-8 assay and plate clone formation to assess cell proliferationin vitro. Apoptotic rate of cultured GC cells was detected by flow cytometry with double staining of AnnxinV/PI. The xenografted mouse model was used to ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 1, 2021 Category: Research Source Type: research

Long Noncoding RNASBF2-AS1 Promotes Gastric Cancer Progression via Regulating miR-545/EMS1 Axis.
Conclusion: These findings elucidated a crucial role of SBF2-AS1 as a miR-545 sponge in GC cells, suggesting that SBF2-AS1 might be a potential target for GC. PMID: 32626753 [PubMed - in process]
Source: Biomed Res - July 8, 2020 Category: Research Authors: He M, Feng L, Qi L, Rao M, Zhu Y Tags: Biomed Res Int Source Type: research

Inhibition of Splicing Factor 3b Subunit 1 (SF3B1) Reduced Cell Proliferation, Induced Apoptosis and Resulted in Cell Cycle Arrest by Regulating Homeobox A10 (HOXA10) Splicing in AGS and MKN28 Human Gastric Cancer Cells.
CONCLUSIONS In AGS and MKN28 human gastric cancer cells in vitro, inhibition of SF3B1 reduced cell proliferation, induced apoptosis, and resulted in cell cycle arrest by regulating HOXA10 splicing. PMID: 31927557 [PubMed - in process]
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Tumor-associated macrophages induce invasion and poor prognosis in human gastric cancer in a cyclooxygenase-2/MMP9-dependent manner.
Authors: Xu J, Yu Y, He X, Niu N, Li X, Zhang R, Hu J, Ma J, Yu X, Sun Y, Ni H, Wang F Abstract Cyclooxygenase-2 (COX2) and tumor-associated macrophages (TAMs) are associated with invasion, angiogenesis, and poor prognosis in many human cancers. However, the role of TAMs in human gastric cancer (GC) remains elusive. In the present study, we first measured COX2 expression and TAM infiltration in human GC tissues using double immunohistochemical staining. Then, we indirectly cocultured M2-polarized macrophages derived from human THP-1 cells with GC cells as an in vitro model. Transwell assays, siRNA transfection, tre...
Source: American Journal of Translational Research - October 23, 2019 Category: Research Tags: Am J Transl Res Source Type: research

LaSota Strain Expressing The Rabies Virus Glycoprotein (rL-RVG) Suppresses Gastric Cancer by Inhibiting the Alpha 7 Nicotinic Acetylcholine Receptor ( α7 nAChR)/Phosphoinositide 3-Kinase (PI3K)/AKT Pathway.
CONCLUSIONS rL-RVG leads to much greater apoptosis through the alpha7-nAChR/PI3K/AKT pathway. PMID: 31337746 [PubMed - in process]
Source: Medical Science Monitor - July 25, 2019 Category: Research Tags: Med Sci Monit Source Type: research

NADPH oxidase 4 is correlated with gastric cancer progression and predicts a poor prognosis.
In conclusion, NOX4 is related to gastric cancer development and predicts a poor prognosis. NOX4 may play an essential role in the progression of gastric cancer, and is a promising target for the prevention and treatment of gastric cancer. PMID: 31312363 [PubMed]
Source: American Journal of Translational Research - July 19, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Downregulation of annexin A7 decreases proliferation, migration, and invasion of gastric cancer cells by reducing matrix metalloproteinase 1 and 9 expression.
Authors: Yuan HF, Li Y, Ye WH, Liu Y, Zhang ZD, Tan BB, Fan LQ, Zhao Q, Wang D, Jia N, Hao YJ Abstract High annexin A7 expression is a potential indicator of lymphatic metastasis and poor prognosis in patients with gastric cancer (GC). The mechanism underlying the effects of annexin A7 on GC cells remains unclear. In patients with GC, primary adenocarcinoma tissues had higher annexin A7 expression than adjacent non-cancerous tissues (P < 0.05). Among three human GC cell lines with high, moderate, and low levels of differentiation, respectively, the cell line with the lowest level of differentiation displayed the...
Source: American Journal of Translational Research - June 22, 2019 Category: Research Tags: Am J Transl Res Source Type: research

A novel circular RNA hsa_circ_0008035 contributes to gastric cancer tumorigenesis through targeting the miR-375/YBX1 axis.
This study aims to uncover the mechanism by which circRNAs regulate gastric cancer tumorigenesis. Among the microarray data, we screened dysregulated circRNAs and identified an up-regulated circRNA, hsa_circ_0008035. Functionally, the hsa_circ_0008035 silencing by the siRNA transfection inhibited the proliferation and invasion of gastric cancer cells. Mechanically, hsa_circ_0008035 acted as a sponge for the miR-375 and absorbed its expression, and miR-375 was found to target YBX1 3'-UTR, constructing a hsa_circ_0008035/miR-375/YBX1 axis. Taken together, these findings are evidence that circRNA hsa_circ_0008035 promotes gas...
Source: American Journal of Translational Research - May 22, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Regulation of Proliferation and Epithelial-to-Mesenchymal Transition (EMT) of Gastric Cancer by ZEB1 via Modulating Wnt5a and Related Mechanisms.
CONCLUSIONS ZEB1 expression is increased in GC tumor tissues and is associated with pathological features. The downregulation of ZEB1 can facilitate cell apoptosis via mediating Wnt5a, further suppressing GC cell proliferation and migration, and reducing EMT occurrence. PMID: 30829316 [PubMed - in process]
Source: Medical Science Monitor - March 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Signaling.
CONCLUSIONS LncRNA MIR22HG suppressed gastric cancer progression through attenuating NOTCH2 signaling. PMID: 30670679 [PubMed - in process]
Source: Medical Science Monitor - January 24, 2019 Category: Research Tags: Med Sci Monit Source Type: research

eIF5A2 regulates the resistance of gastric cancer cells to cisplatin via induction of EMT.
This study aimed to investigate the role of eIF5A2 in cisplatin resistance of GC cells and its relationship with epithelial-mesenchymal transition (EMT). We found that it is negative correlation between cisplatin resistance and eIF5A2's expression in GC cells. Silencing of eIF5A2 enhanced the sensitivity of GC cells to cisplatin, while overexpression of eIF5A2 decreased sensitivity. Cisplatin treatment induced gene expression changes consistent with EMT. EMT was blocked and the sensitivity of GC cells to cisplatin was increased by inhibiting the expression of Twist, indicating that EMT regulates the sensitivity of GC cells...
Source: American Journal of Translational Research - January 24, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Silencing ELMO3 Inhibits the Growth, Invasion, and Metastasis of Gastric Cancer.
Abstract ELMO3 is a member of the engulfment and cell motility (ELMO) protein family, which plays a vital role in the process of chemotaxis and metastasis of tumor cells. However, remarkably little is known about the role of ELMO3 in cancer. The present study was conducted to investigate the function and role of ELMO3 in gastric cancer (GC) progression. The expression level of ELMO3 in gastric cancer tissues and cell lines was measured by means of real-time quantitative PCR (qPCR) and Western blot analysis. RNA interference was used to inhibit ELMO3 expression in gastric cancer cells. Then, wound-healing assays, T...
Source: Biomed Res - October 24, 2018 Category: Research Authors: Hu Y, Yu Q, Zhong Y, Shen W, Zhou X, Liu X, Xu M, Zhou N, Min W, Gao D Tags: Biomed Res Int Source Type: research

URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion.
Abstract Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate cancer tissues, URG11 was found significantly upregulated and positively correlated with the severity of prostate cancer, compared with that in benign prostatic hyperplasia tissues. Further, the mRNA and protein levels of URG11 were significantly upregulated in human prostate cancer cell lin...
Source: Biomed Res - June 30, 2018 Category: Research Authors: Pan B, Ye Y, Liu H, Zhen J, Zhou H, Li Y, Qu L, Wu Y, Zeng C, Zhong W Tags: Biomed Res Int Source Type: research