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Metabolic Switch Under Glucose Deprivation Leading to Discovery of NR2F1 as a Stimulus of Osteoblast Differentiation
In conclusion, the results of this study provide an understanding of the metabolic profile of implanted cells in an ischemic microenvironment and demonstrate that NR2F1 treatment may overcome this deprivation by enhancing AKT and ERK regulation. These findings can be utilized in regenerative medicine for bone regeneration. © 2022 American Society for Bone and Mineral Research (ASBMR).
Source: Journal of Bone and Mineral Research - May 23, 2022 Category: Orthopaedics Authors: Eugene Lee, Seo ‐Young Park, Jae‐Yeon Moon, Ji‐Yun Ko, Tae Kyung Kim, Gun‐Il Im Tags: Original Article Source Type: research

Metabolic switch under glucose deprivation leading to discovery of NR2F1 as a stimulus of osteoblast differentiation
In conclusion, the results of this study provide an understanding of the metabolic profile of implanted cells in an ischemic microenvironment and demonstrate that NR2F1 treatment may overcome this deprivation by enhancing AKT and ERK regulation. These findings can be utilized in regenerative medicine for bone regeneration.This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - April 24, 2022 Category: Orthopaedics Authors: Eugene Lee, Seo ‐Young Park, Jae‐Yeon Moon, Ji‐Yun Ko, Tae Kyung Kim, Gun‐Il Im Tags: Original Article Source Type: research

Delta-like Factor 1 as a Possible Therapeutic Target for Sarcomas.
Conclusions: Our study showed that the DLK1 gene induces tumorigenesis in various sarcomas and is associated with invasive mechanism in sarcoma. These results suggest DLK1 could serve as a possible therapeutic target in a variety of sarcomas. PMID: 32904069 [PubMed - in process]
Source: Clinics in Orthopedic Surgery - September 11, 2020 Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research

Stearic acid methyl ester ​promotes migration of mesenchymal stem cells and accelerates cartilage defect repair
Publication date: Available online 23 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Yamei Liu, Liangliang Xu, Liuchao Hu, Dongfeng Chen, Lijuan Yu, Xican Li, Hongtai Chen, Junlang Zhu, Chen Chen, Yiwen Luo, Bin Wang, Gang LiAbstractMesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homin...
Source: Journal of Orthopaedic Translation - October 24, 2019 Category: Orthopaedics Source Type: research

Glucocorticoid Enhanced the Expression of Ski in Osteonecrosis of Femoral Head: The Effect on Adipogenesis of Rabbit BMSCs
AbstractGlucocorticoid (GC)-induced osteonecrosis has been considered as the most serious side effect in long-term or over-dose steroid therapy. The decreased bone mass and increased marrow fat tissue demonstrated that GC can destroy the normal differentiation of bone marrow mesenchymal stem cells (BMSCs), which accelerates adipogenesis but not osteogenesis. However, the underlying mechanisms are still unclear. Ski, an evolutionary conserved protein, is a multifunctional transcriptional regulator that involved in regulating signaling pathways associated with adipogenesis differentiation, but the concrete function remains u...
Source: Calcified Tissue International - July 29, 2019 Category: Orthopaedics Source Type: research

Sonic Hedgehog Promotes Cementoblastic Differentiation via Activating the BMP Pathways
Abstract Although sonic hedgehog (SHH), an essential molecule in embryogenesis and organogenesis, stimulates proliferation of human periodontal ligament (PDL) stem cells, the effects of recombinant human SHH (rh-SHH) on osteoblastic differentiation are unclear. To reveal the role of SHH in periodontal regeneration, expression of SHH in mouse periodontal tissues and its effects on the osteoblastic/cementoblastic differentiation in human cementoblasts were investigated. SHH is immunolocalized to differentiating cementoblasts, PDL cells, and osteoblasts of the developing mouse periodontium. Addition of rh-SHH increas...
Source: Calcified Tissue International - June 10, 2016 Category: Orthopaedics Source Type: research

Effects of hyperbaric oxygen on the osteogenic differentiation of mesenchymal stem cells
Conclusion: HBO treatment increased osteogenic differentiation of MSCs via regulating Wnt processing, secretion, and signaling.
Source: BMC Musculoskeletal Disorders - February 25, 2014 Category: Orthopaedics Authors: Song-Shu LinSteve UengChi-Chien NiuLi-Jen YuanChuen-Yung YangWen-Jer ChenMel LeeJan-Kan Chen Source Type: research