Metabolic Switch Under Glucose Deprivation Leading to Discovery of NR2F1 as a Stimulus of Osteoblast Differentiation

In conclusion, the results of this study provide an understanding of the metabolic profile of implanted cells in an ischemic microenvironment and demonstrate that NR2F1 treatment may overcome this deprivation by enhancing AKT and ERK regulation. These findings can be utilized in regenerative medicine for bone regeneration. © 2022 American Society for Bone and Mineral Research (ASBMR).

https://onlinelibrary.wiley.com/doi/10.1002/jbmr.4565?af=R

Source: Journal of Bone and Mineral Research - May 23, 2022 Category: Orthopaedics Authors: Eugene Lee, Seo ‐Young Park, Jae‐Yeon Moon, Ji‐Yun Ko, Tae Kyung Kim, Gun‐Il Im Tags: Original Article Source Type: research