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Specialty: Cytology
Cancer: Gastric (Stomach) Cancer
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Total 49 results found since Jan 2013.
Targeting Nanog expression increased Cisplatin chemosensitivity and inhibited cell migration in Gastric cancer cells
Exp Cell Res. 2023 Jun 12:113681. doi: 10.1016/j.yexcr.2023.113681. Online ahead of print.ABSTRACTRegardless of significant advances in cancer treatment, gastric cancer (GC) incidence rate is increasing worldwide. As one of the main transcription factors participating in stemness, Nanog plays a pivotal role in various aspects of tumorigenesis, metastasis, and chemosensitivity. Given that, the current research intended to evaluate the potential effects of Nanog suppression on the GC cell cisplatin chemosensitivity and in vitro tumorigenesis. First, bioinformatics analysis was performed to evaluate the effect of Nanog expres...
Source: Experimental Cell Research - June 14, 2023 Category: Cytology Authors: Parisa Vasefifar Souzan Najafi Rouhollah Motafakkerazad Mohammad Amini Sahar Safaei Basira Najafzadeh Hajar Alemohammad Mahdi Jafarlou Behzad Baradaran Source Type: research
Linc-ROR Regulates < em > POU5F1 < /em > and < em > SOX2 < /em > by Competitively Binding miR-145-5p to Affect the Proliferation and Migration of Gastric Cancer Cells
In this study, in situ hybridization revealed that long intergenic non-protein coding RNA-regulator of reprogramming (linc-ROR) was highly expressed in gastric cancer cells and was mainly cytoplasmic-positive. Cell counting kit-8 (CCK-8), plate colony formation, wound healing, and Transwell assay revealed that linc-ROR knockdown impedes the growth, proliferation, and migration of gastric cancer cells, while linc-ROR overexpression promoted gastric cancer cell growth, migration, and colony formation ability. Combined with previous studies, the molecular mechanism axis of linc-ROR/miR-145-5-5p/POU5F1/SOX2 was verified. The e...
Source: Cell Transplantation - June 12, 2023 Category: Cytology Authors: Xiuchong Yu Xinyi Ma Yangtao Jia Xinxin Wu Zhilong Yan Source Type: research
Silence of URI in gastric cancer cells promotes cisplatin-induced DNA damage and apoptosis
In conclusion, our results suggest that URI is involved in the cisplatin-induced DNA damage response via the ATM/CHK2 pathway, and silencing URI can increase cisplatin-induced DNA damage and enhance drug sensitivity in gastric cancer cells.PMID:37034221 | PMC:PMC10077030
Source: Cell Research - April 10, 2023 Category: Cytology Authors: Huiqin Bian Yu Gu Chen Chen Jinnan Chen Fei Zhang Zhonghai Xu Qian Wang Rui Mi Xuan Wu Yaojuan Lu Qiping Zheng Junxia Gu Source Type: research
Inhibition of EP2 receptor suppresses tumor growth and chemoresistance of gastric cancer
In this study, we found that expression of EP2 receptor was significantly upregulated in gastric cancer. Inhibition of EP2 receptor reduced gastric cancer cell proliferation, induced cell cycle arrest proteins, and enhanced cell apoptosis. Moreover, knockdown of EP2 receptor by siRNA or antagonist sensitized gastric cancer cells to ECF. Silence of EP2 receptor also significantly abrogated gastric cancer growth in a mice model. Analysis revealed that CAV1 was a downstream target of EP2 receptor in gastric cancer. Our findings illustrated that blocking EP2 receptor reduced tumor growth and induced apoptosis in gastric cancer...
Source: Cell Research - November 16, 2022 Category: Cytology Authors: Vivian Yvonne Shin Michelle Xin Liu Jennifer Man-Ting Siu Ava Kwong Kent-Man Chu Source Type: research
DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer
CONCLUSIONS: Our study revealed a novel deubiquitinase in the Hippo/TAZ axis and identified one possible therapeutic target for Hippo-driven gastric cancer.PMID:35820928 | DOI:10.1186/s13046-022-02410-5
Source: Cell Research - July 12, 2022 Category: Cytology Authors: Dehai Wang Zhongbo Li Xin Li Cheng Yan Huijie Yang Ting Zhuang Xiao Wang Yifeng Zang Ziping Liu Tianshi Wang Rixia Jiang Peng Su Jian Zhu Yinlu Ding Source Type: research
The impact of PIK3R1 mutations and insulin-PI3K-glycolytic pathway regulation in prostate cancer
CONCLUSIONS: Our findings describe a novel genomic feature in metastatic prostate cancer and suggest that PIK3R1 alteration may be a key event for insulin-PI3K-glycolytic pathway regulation in prostate cancer.PMID:35670774 | DOI:10.1158/1078-0432.CCR-21-4272
Source: Cell Research - June 7, 2022 Category: Cytology Authors: Goutam Chakraborty Subhiksha Nandakumar Rahim Hirani Bastien Nguyen Konrad H Stopsack Christoph Kreitzer Sai Harisha Rajanala Romina Ghale Ying Z Mazzu Naga Vara Kishore Pillarsetty Gwo-Shu Mary Lee Howard I Scher Michael J Morris Tiffany Traina Pedram Ra Source Type: research
LMP2A inhibits the expression of KLF5 through the mTORC1 pathway in EBV-associated gastric carcinoma
CONCLUSION: LMP2A downregulated KLF5 expression by inhibiting the mTORC1 pathway in EBV positive GC cells. KLF5 might play an oncogene-like role by promoting the migration of GC cells and inducing autophagy.PMID:35500764 | DOI:10.1016/j.virusres.2022.198792
Source: Cell Research - May 2, 2022 Category: Cytology Authors: Dandan Liu Duo Shi Lin Xu Lingling Sun Shuzhen Liu Bing Luo Source Type: research
Disruption of the CCDC43-FHL1 interaction triggers apoptosis in gastric cancer cells
Exp Cell Res. 2022 Mar 16:113107. doi: 10.1016/j.yexcr.2022.113107. Online ahead of print.ABSTRACTThe coiled-coil domain-containing protein 43 (CCDC43) is essential to promote gastric cancer (GC) proliferation and invasion, while four and a half LIM domains 1 (FHL1) involves GC cells apoptosis. We attempted to address inter-relationship between CCDC43 and FHL1 in modulating GC cells growth and apoptosis. Levels of protein expression were assessed by western blot, immunofluorescence. Using EdU, plate colony formation, Matrigel invasion and animal models, we evaluated the function in vitro and in vivo. Apoptosis was evaluate...
Source: Experimental Cell Research - March 20, 2022 Category: Cytology Authors: Yaying Chen Miaomiao Pei Jiaying Li Zhi Wang Side Liu Li Xiang Jieming Zhang Linjie Hong Jianjiao Lin Weiyu Dai Yizhi Xiao Hongsong Hu Weimei Tang Guangnan Liu Qiong Yang Zhizhao Lin Xiaoling Jiang Yusi Wang Xiaosheng Wu Zheng Guo Jide Wang Source Type: research
Olaparib-induced Apoptosis Through EBNA1-ATR-p38 MAPK Signaling Pathway in Epstein-Barr Virus-positive Gastric Cancer Cells
CONCLUSION: Olaparib treatment led to different cellular responses depending on EBV infection in gastric cancer cell lines. These results provide new insights into the mechanism of olaparib-induced apoptosis in gastric cancer cells and suggest that EBV infection should be considered when developing new potential therapeutic agents for gastric cancer.PMID:34969765 | DOI:10.21873/anticanres.15513
Source: Cell Research - December 31, 2021 Category: Cytology Authors: Sung Ho Moon Nam-Sook Park Min Hye Noh Yeong Seok Kim Soon Ho Cheong Dae Young Hur Source Type: research
miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1
CONCLUSION: miRNA-149 inhibits the biological behavior of gastric cancer by targeting FOXC1, providing a promising target in the treatment of human gastric cancer.PMID:34957298 | PMC:PMC8709748 | DOI:10.1155/2021/1503403
Source: Cell Research - December 27, 2021 Category: Cytology Authors: Dan Li Yunqing Zhang Yulong Li Xiaofei Wang Fenghui Wang Juan Du Huahua Zhang Haiyan Shi Yanfeng Wang Yi Gao Yun Feng Jing Yan Yajuan Xue Yang Yang Jing Zhang Source Type: research
