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Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
ConclusionThese findings demonstrate a previously unidentified vitamin D/VDR-MUC1 signaling axis involved in the regulation of gemcitabine resistance in PDA and suggests that combinational therapies that include targeted activation of vitamin D/VDR signaling may improve the outcomes of patients with PDA.
Source: Digestive Diseases and Sciences - April 18, 2023 Category: Gastroenterology Source Type: research

Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling
ConclusionsOur results indicate that the effects of vitamin D on Cl-2 and Cl-4 are mediated by p-Stat-6 and Smad-7 signal, respectively. The study suggests that vitamin D administration to UC patients could be a useful therapeutic intervention, given that vitamin D deficiency is found in these patients.
Source: International Journal of Colorectal Disease - June 26, 2020 Category: Gastroenterology Source Type: research

Effect of bacterial flagellin on thiamin uptake by human and mouse pancreatic acinar cells: Inhibition mediated at the level of transcription of THTR-1 and 2.
Abstract Thiamin (vitamin B1) is essential for normal cellular metabolism and function. Pancreatic acinar cells (PACs) obtain thiamin from circulation, via a specific carrier-mediated process that involves the plasma membrane thiamin transporters -1 and -2 (THTR-1 and THTR-2; products of SLC19A2 and SLC19A3 genes, respectively). There is nothing known about the effect of bacterial products/toxins on thiamin uptake by PACs. We addressed this issue in the current investigation by examining the effect of the bacterial flagellin on physiological and molecular parameters of the thiamin uptake by PACs. We used human pri...
Source: Am J Physiol Gastroi... - March 27, 2019 Category: Gastroenterology Authors: Srinivasan P, Anandam KY, Ramesh V, Geltz ET, Said HM Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Vitamin D differentially regulates Salmonella-induced intestine epithelial autophagy and interleukin-1 β expression.
CONCLUSION: Active vitamin D might enhance autophagic clearance of Salmonella infection, while modulation of inflammatory responses prevents the host from detrimental effects of overwhelming inflammation. PMID: 28058015 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 20, 2016 Category: Gastroenterology Authors: Huang FC Tags: World J Gastroenterol Source Type: research

Helicobacter pylori Induces Increased Expression of the Vitamin D Receptor in Immune Responses
ConclusionsThe expression of VDR and CAMP in the gastric epithelium is up‐regulated in the case of H. pylori infection; thus, VDR plays an important role in gastric mucosa homeostasis and host protection from H. pylori infection.
Source: Helicobacter - November 5, 2013 Category: Gastroenterology Authors: Lihua Guo, Wenguo Chen, Huatuo Zhu, Yu Chen, Xingyong Wan, Ningmin Yang, Shuhua Xu, Chaohui Yu, Lihua Chen Tags: Original Article Source Type: research

Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis
The human sodium-dependent vitamin C transporter 1 (hSVCT1) contributes to cellular uptake of ascorbic acid (AA). Although different aspects of hSVCT1 cell biology have been extensively studied, nothing is currently known about the broader hSVCT1 interactome that modulates its role in cellular physiology. Here, we identify the enzyme human glyoxalate reductase/hydroxypyruvate reductase (hGR/HPR) as an hSVCT1 associated protein by yeast two-hybrid (Y2H) screening of a human liver cDNA library. The interaction between hSVCT1 and hGR/HPR was further confirmed by in vitro GST pull-down assay, in vivo coimmunoprecipitation and ...
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Subramanian, V. S., Nabokina, S. M., Patton, J. R., Marchant, J. S., Moradi, H., Said, H. M. Tags: LIVER AND BILIARY TRACT Source Type: research