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Specialty: Laboratory Medicine
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Total 432 results found since Jan 2013.
Decreased Expression of HN1 Sensitizes Prostate Cancer Cells to Apoptosis Induced by Docetaxel and 2-Methoxyestradiol
CONCLUSION: HN1 is an anti-apoptotic molecule and inhibits Docetaxel and 2-Methoxyestradiol induced apoptosis by targeting Cyclin B1.PMID:35414498
Source: Annals of Clinical and Laboratory Science - April 13, 2022 Category: Laboratory Medicine Authors: Lokman Varisli Source Type: research
ETC-1002 Attenuates < em > Porphyromonas gingivalis < /em > Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells < em > via < /em > the AMPK/NF- < em > κ < /em > B Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice
CONCLUSIONS: ETC-1002 exerts anti-inflammatory effects in Pg-LPS-treated RAW264.7 cells via the AMPK/NF-κB pathway in vitro and inhibits the progress of experimental periodontitis in mice in an AMPK signaling-dependent manner in vivo. These results provide evidence for the beneficial effects of ETC-1002 in the treatment of periodontitis.PMID:35340409 | PMC:PMC8942644 | DOI:10.1155/2022/8583674
Source: Disease Markers - March 28, 2022 Category: Laboratory Medicine Authors: Hongyan Li Peipei Zhang Hongbing Lin Huan Gao Jianyuan Yin Source Type: research
Effects of Long Noncoding RNA HOTAIR Targeting miR-138 on Inflammatory Response and Oxidative Stress in Rat Cardiomyocytes Induced by Hypoxia and Reoxygenation
CONCLUSIONS: Silent HOTAIR can promote the expression of miR-138 and inhibit H/R-induced inflammatory response and OS by regulating the NF-κB pathway, thus protecting cardiomyocytes.PMID:34970356 | PMC:PMC8714338 | DOI:10.1155/2021/4273274
Source: Disease Markers - December 31, 2021 Category: Laboratory Medicine Authors: Guofeng Wang Qi Wang Weixue Xu Source Type: research
RUNX3 is up-regulated in abdominal aortic aneurysm and regulates the function of vascular smooth muscle cells by regulating TGF- β1
AbstractAbdominal aortic aneurysm (AAA) has been associated with the dysfunction of vascular smooth muscle cells (VSMCs) and extracellular matrix (ECM) remodelling. Runt-related transcription factor 3 (RUNX3) has been reported to be up-regulated in aneurysmal aorta samples compared with normal aorta. However, its function in VSMCs and the mechanism of function remains unknown. Therefore, our study aimed to investigate the role of RUNX3 in ECM remodelling and VSMC function, and further explore the underlying mechanism. Our results verified that RUNX3 was increased in aortic samples of AAA compared with healthy controls. Ove...
Source: Journal of Molecular Histology - November 23, 2021 Category: Laboratory Medicine Source Type: research
Identification and Validation of a Proliferation-Associated Score Model Predicting Survival in Lung Adenocarcinomas
CONCLUSION: The proposed score model may function as a promising risk prediction tool for patients with lung adenocarcinoma and provide insights into the molecular regulation mechanism of lung adenocarcinoma.PMID:34721732 | PMC:PMC8554523 | DOI:10.1155/2021/3219594
Source: Disease Markers - November 1, 2021 Category: Laboratory Medicine Authors: Yunyi Bian Qihai Sui Guoshu Bi Yuansheng Zheng Mengnan Zhao Guangyu Yao Liang Xue Yi Zhang Hong Fan Source Type: research
Phactr1 negatively regulates bone mass by inhibiting osteogenesis and promoting adipogenesis of BMSCs via RhoA/ROCK2
AbstractThe imbalance between osteogenic and adipogenic differentiation of Bone marrow-derived mesenchymal stem cells (BMSCs) is involved in the occurrence and development of osteoporosis (OP). Previous studies have indicated the potential of phosphatase and actin regulator 1 (Phactr1) in regulating osteogenic and adipogenic differentiation of BMSCs. The present study aims to investigate the function and mechanism of Phactr1 in regulating osteogenic and adipogenic differentiation of BMSCs. Herein, the expression of Phactr1 in bone and adipose tissue of OP rats was determined by immunohistochemical. BMSCs were subjected to ...
Source: Journal of Molecular Histology - October 28, 2021 Category: Laboratory Medicine Source Type: research
UDP-Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K/AKT Pathway
CONCLUSION: The knockdown of UGCG exerted an anti-tumor effect against cervical cancer through the inactivation of the PI3K/AKT pathway.PMID:34686508
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Fenyun Zhang Hao Zhang Source Type: research
