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Specialty: Laboratory Medicine
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Total 432 results found since Jan 2013.
Gasdermin D mediates doxorubicin- induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage
Transl Res. 2022 May 8:S1931-5244(22)00100-1. doi: 10.1016/j.trsl.2022.05.001. Online ahead of print.ABSTRACTDoxorubicin (Dox), as a widely used anthracycline antitumor drug, can cause severe cardiotoxicity. Cardiomyocyte death and inflammation are involved in the pathophysiology of Dox-induced cardiotoxicity (DIC). Gasdermin D (GSDMD) is known as a key executioner of pyroptosis, which is a pro-inflammatory programmed cell death. We aimed to investigate the impact of GSDMD on DIC and systematically reveal its underlying mechanisms. Our findings indicated that Dox induced cardiomyocyte pyroptosis in a GSDMD-dependent manner...
Source: Translational Research : the journal of laboratory and clinical medicine - May 11, 2022 Category: Laboratory Medicine Authors: Bozhi Ye Xiaowen Shi Jianjiang Xu Shanshan Dai Jiajun Xu Xiaoxi Fan Bingjiang Han Jibo Han Source Type: research
SIRT2 Affects Cell Proliferation and Apoptosis by Suppressing the Level of Autophagy in Renal Podocytes
CONCLUSION: SIRT2 expression was upregulated in hyperglycaemic murine kidney foot cells, and knocking down the expression level of SIRT2 affected the biological function of the cells. We found that SIRT2 may modulate cell proliferation and apoptosis by regulating cell autophagy.PMID:35493297 | PMC:PMC9054447 | DOI:10.1155/2022/4586198
Source: Disease Markers - May 2, 2022 Category: Laboratory Medicine Authors: Shuang Liu Xiangfu Gao Zhenliang Fan Qiao Wang Source Type: research
Involvement of RUVBL1 in WNT/ < em > β < /em > -Catenin Signaling in Oral Squamous Cell Carcinoma
Dis Markers. 2022 Apr 22;2022:3398492. doi: 10.1155/2022/3398492. eCollection 2022.ABSTRACTOral squamous cell carcinoma (OSCC) is the most common malignant tumor of head and neck squamous cell carcinoma (HNSCC), but the causes and molecular mechanisms remain unclear. The wingless-integrated/β-catenin (WNT/β-catenin) signaling pathway plays a vital role in cancer cell proliferation, differentiation, and metastasis, including OSCC. To screen potential β-catenin-associated genes involved in OSCC, the intersection of these genes in the STRING and IMEx databases was assessed using differential expression genes (DEG) from pub...
Source: Disease Markers - May 2, 2022 Category: Laboratory Medicine Authors: Yongfa Zeng Ying Kong Lan Liao Hongshui Zhu Source Type: research
SIRT2 Affects Cell Proliferation and Apoptosis by Suppressing the Level of Autophagy in Renal Podocytes
CONCLUSION: SIRT2 expression was upregulated in hyperglycaemic murine kidney foot cells, and knocking down the expression level of SIRT2 affected the biological function of the cells. We found that SIRT2 may modulate cell proliferation and apoptosis by regulating cell autophagy.PMID:35493297 | PMC:PMC9054447 | DOI:10.1155/2022/4586198
Source: Disease Markers - May 2, 2022 Category: Laboratory Medicine Authors: Shuang Liu Xiangfu Gao Zhenliang Fan Qiao Wang Source Type: research
Involvement of RUVBL1 in WNT/ < em > β < /em > -Catenin Signaling in Oral Squamous Cell Carcinoma
Dis Markers. 2022 Apr 22;2022:3398492. doi: 10.1155/2022/3398492. eCollection 2022.ABSTRACTOral squamous cell carcinoma (OSCC) is the most common malignant tumor of head and neck squamous cell carcinoma (HNSCC), but the causes and molecular mechanisms remain unclear. The wingless-integrated/β-catenin (WNT/β-catenin) signaling pathway plays a vital role in cancer cell proliferation, differentiation, and metastasis, including OSCC. To screen potential β-catenin-associated genes involved in OSCC, the intersection of these genes in the STRING and IMEx databases was assessed using differential expression genes (DEG) from pub...
Source: Disease Markers - May 2, 2022 Category: Laboratory Medicine Authors: Yongfa Zeng Ying Kong Lan Liao Hongshui Zhu Source Type: research
Decreased Expression of HN1 Sensitizes Prostate Cancer Cells to Apoptosis Induced by Docetaxel and 2-Methoxyestradiol
CONCLUSION: HN1 is an anti-apoptotic molecule and inhibits Docetaxel and 2-Methoxyestradiol induced apoptosis by targeting Cyclin B1.PMID:35414498
Source: Annals of Clinical and Laboratory Science - April 13, 2022 Category: Laboratory Medicine Authors: Lokman Varisli Source Type: research
