ETC-1002 Attenuates Porphyromonas gingivalis Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells via the AMPK/NF- κ B Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice

CONCLUSIONS: ETC-1002 exerts anti-inflammatory effects in Pg-LPS-treated RAW264.7 cells via the AMPK/NF-κB pathway in vitro and inhibits the progress of experimental periodontitis in mice in an AMPK signaling-dependent manner in vivo. These results provide evidence for the beneficial effects of ETC-1002 in the treatment of periodontitis.PMID:35340409 | PMC:PMC8942644 | DOI:10.1155/2022/8583674

https://pubmed.ncbi.nlm.nih.gov/35340409/?utm_source=no_user_agent&utm_medium=rs...

Source: Disease Markers - March 28, 2022 Category: Laboratory Medicine Authors: Hongyan Li Peipei Zhang Hongbing Lin Huan Gao Jianyuan Yin Source Type: research

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ETC-1002 Attenuates < em > Porphyromonas gingivalis < /em > Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells < em > via < /em > the AMPK/NF- < em > κ < /em > B Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice