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BMP4 Regulates EMT to be Involved in non-Syndromic Cleft lip With or Without Palate
CONCLUSIONS: BMP4 enhances cell migration and promotes cell EMT through Smad1 signaling pathway. Abnormal BMP4 mediates migration and EMT through other relevant signaling pathways resulting in NSCL/P. The study provides new insight into the mechanisms of NSCL/P associated with BMP4.n.PMID:35702016 | DOI:10.1177/10556656221105762
Source: The Cleft Palate-Craniofacial Journal - June 15, 2022 Category: ENT & OMF Authors: Jia-Wei Hong Yue Yu Lu-Shan Wang Zheng Li Rui Zhang Qi Wang Zhen Ding Jin-Peng Zhang Mei-Rong Zhang Li-Chun Xu Source Type: research

Assessment of cervical lymph node metastasis based on total RNA from saliva and tumor tissue in patients with oral squamous cell carcinoma: An observational study
Conclusion: Saliva and tumor tissue RNA can be a good marker for pretreatment assessment of lymph node metastasis in patients with OSCC. Although the diagnostic accuracy which range from 63% to 65%, further characterization and study of specific mRNA, siRNA and miRNA may come out with high diagnostic accuracy.
Source: Journal of Oral and Maxillofacial Pathology - September 8, 2020 Category: ENT & OMF Authors: Kiran B Jadhav Vandana Shah Ghansham Parmar Nirali Chauhan Naveen Shah Nidhi Gupta Source Type: research

Ladinin-1 is involved in cell motility and proliferation of oral squamous cell carcinoma cells
ConclusionsLAD1 is potentially involved in modulation of actin dynamics in oral SCC cells, affecting their motility and proliferation at the interface between cancer and non-cancerous tissue.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - June 13, 2019 Category: ENT & OMF Source Type: research

NFκB Silencing Induces Chromatin Acetylation and Ablates Resistance to Cisplatin in Head and Neck Cancer
Conclusion: Our results suggest that HDAC inhibitors and NFκB targeted therapies may represent viable adjuvant chemotherapy to revert HNSCC resistant to platinum-based therapies.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 21, 2014 Category: ENT & OMF Authors: ALINE CORREA ABRAHAO, LUCIANA O. ALMEIDA, LUCIANA K. ROSSELLI-MURAI, FERNANDA S. GIUDICE, ANDREIA M. LEOPOLDINO, CRISTIANE H. SQUARIZE, ROGERIO M. CASTILHO Tags: Online Only Articles Source Type: research

Relation between the expression of mitotic centromere–associated kinesin and the progression of squamous cell carcinoma of the tongue
Objective: Mitotic centromere–associated kinesin (MCAK) is a microtubule depolymerase indispensable for microtubule binding during spindle formation. The purpose of this study was to investigate the association of MCAK expression with squamous cell carcinoma of the oral tongue (SCCOT).Study Design: Immunohistochemistry was used in 47 cases of SCCOT. Determination of proliferation and migratory capabilities was performed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Transwell chamber assay, respectively, on cells from the human tongue squamous cell carcinoma cell line Tca8113 that were ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - November 22, 2013 Category: ENT & OMF Authors: Cheng-Qin Wang, Feng-Gang Xiang, Yu-Jun Li, Xiao-Ming Xing, Ning Wang, Jing-Hua Chi, Wen-Juan Yu Tags: Oral and Maxillofacial Pathology Source Type: research

The in vitro apoptotic effects of A248 and A1659, newly synthetic histone deacetylase inhibitors in oral cancer cells
ConclusionThese results suggest that A248 and A1659, two new HDAC inhibitors, may be attractive therapeutic drug candidates for targeting Sp1 in human oral cancer cells.
Source: Oral Diseases - July 14, 2013 Category: ENT & OMF Authors: J‐A Shin, G Han, S‐K Park, K Lee, H‐J Kim, S‐D Cho, HM Kim Tags: Original Article Source Type: research

The in vitro apoptotic effects of A248 and A1659, newly synthetic HDAC inhibitors in oral cancer cells
ConclusionThese results suggest that A248 and A1659, two new HDAC inhibitors may be attractive therapeutic drug candidates for targeting Sp1 in human oral cancer cells.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - July 1, 2013 Category: ENT & OMF Authors: Ji‐Ae Shin, Gyoonhee Han, Song‐Kyu Park, Kiho Lee, Hyun‐Jung Kim, Sung‐Dae Cho, Hwan Mook Kim Tags: Original Article Source Type: research

Stable gene-silence of Kif2a synergistic with 5-fluorouracil suppresses oral tongue squamous cell carcinoma growth in vitro and in vivo
Conclusions: Our data support that Kif2a is a potential molecular target for the therapeutics of recurrent and metastatic SCCOT.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 8, 2013 Category: ENT & OMF Authors: Cheng-Qin Wang, Yu-Jun Li, Zhi-Min Wei, Chang-Jun Zhu, Xun Qu, Feng-Cai Wei, Xiao-Ming Xing, Wen-Juan Yu Tags: Oral Medicine Source Type: research

Apoptotic effect of dibenzylideneacetone on oral cancer cells via modulation of specificity protein 1 and Bax
ConclusionThese findings suggest that DBA may be a potential anticancer drug candidate to induce apoptosis through down‐regulation of Sp1 in human oral cancer.
Source: Oral Diseases - January 11, 2013 Category: ENT & OMF Authors: H‐J Yu, J‐A Shin, J‐S Nam, B S Kang, S‐D Cho Tags: Original Article Source Type: research