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Specialty: Tropical Medicine

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Total 41 results found since Jan 2013.

AEG-1 participates in high glucose-induced activation of Rho kinase and epithelial–mesenchymal transition in proximal tubular epithelial cells
Conclusions Our results show that AEG-1 acts a key role in high glucose-induced activation of Rho kinase and EMT in HK-2 cells.
Source: Asian Pacific Journal of Tropical Medicine - November 23, 2015 Category: Tropical Medicine Source Type: research

Involvement of α5 integrin in survivin-mediated osteosarcoma metastasis
Conclusions Survivin-directed anti-tumor strategies might be an effective method in the treatment of osteosarcoma.
Source: Asian Pacific Journal of Tropical Medicine - March 22, 2016 Category: Tropical Medicine Source Type: research

The Antiviral RNAi Response in Vector and Non-vector Cells against Orthobunyaviruses
Conclusions/SignificanceThese findings have important implications for our understanding of antiviral RNAi pathways and orthobunyavirus-vector interactions and tropism.
Source: PLoS Neglected Tropical Diseases - January 5, 2017 Category: Tropical Medicine Authors: Isabelle Dietrich Source Type: research

Schistosome infectivity in the snail, Biomphalaria glabrata , is partially dependent on the expression of Grctm6, a Guadeloupe Resistance Complex protein.
by Euan R. O. Allan, Jacob A. Tennessen, Stephanie R. Bollmann, Patrick C. Hanington, Christopher J. Bayne, Michael S. Blouin Schistosomiasis is one of the most important neglected tropical diseases. Despite effective chemotherapeutic treatments, this disease continues to afflict hundreds of millions of people. Understanding the natural intermediate snail hosts of schistosome parasites is vital to the suppression of this disease. A recently identified genomic region in CaribbeanBiomphalaria glabrata snails strongly influences their resistance to infection bySchistosoma mansoni. This region contains novel genes having stru...
Source: PLoS Neglected Tropical Diseases - February 2, 2017 Category: Tropical Medicine Authors: Euan R. O. Allan Source Type: research

Macropinocytosis Dependent Entry of Chikungunya Virus into Human Muscle Cells
This study shows for the first time, that the infectious entry of CHIKV into human muscle cells is mediated by macropinocytosis. Together, the da ta from this study may pave the way for the development of specific inhibitors that target the entry process of CHIKV into cells.
Source: PLoS Neglected Tropical Diseases - August 25, 2019 Category: Tropical Medicine Authors: Ching Hua, Regina Lee Source Type: research

Chikungunya virus requires cellular chloride channels for efficient genome replication
In this study, we investigated the role of host-cell chloride (Cl-) channels on CHIKV replication.We demonstrate that specific pharmacological Cl- channel inhibitors significantly inhibit CHIKV replication in a dose-dependent manner, suggesting that Cl-channels are pro-viral factors in human cells. Further analysis of the effect of the inhibitors on CHIKV attachment, entry, viral protein expression and replicon replication demonstrated that Cl- channels are specifically required for efficient CHIKV genome replication. This was conserved in mosquito cells, where CHIKV replication and genome copy number was significantly red...
Source: PLoS Neglected Tropical Diseases - September 3, 2019 Category: Tropical Medicine Authors: Marietta M üller Source Type: research

Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis
by Alexander F. Flynn, M. Gordon Joyce, Rebekah T. Taylor, Sasisekhar Bennuru, Alyssa R. Lindrose, Spencer L. Sterling, C. Paul Morris, Thomas B. Nutman, Edward Mitre Lymphatic filariasis (LF), a morbid disease caused by the tissue-invasive nematodesWuchereria bancrofti,Brugia malayi, andBrugia timori, affects millions of people worldwide. Global eradication efforts have significantly reduced worldwide prevalence, but complete elimination has been hampered by limitations of current anti-filarial drugs and the lack of a vaccine. The goal of this study was to evaluateB.malayi intestinal UDP-glucuronosyltransferase (Bm-UGT) ...
Source: PLoS Neglected Tropical Diseases - September 11, 2019 Category: Tropical Medicine Authors: Alexander F. Flynn Source Type: research

Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis
by Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Kimiko Izumo, Nobuaki Nakano, Eiji Matsuura, Mineki Saito, Masahiro Nagai, Masahisa Horiuchi, Atae Utsunomiya, Hiroshi Takashima, Ryuji Kubota, Shuji Izumo Human T-cell leukemia virus type 1 (HTLV-1) causes incurable adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Patients with HAM/TSP have increased levels of HTLV-1-infected cells compared with asymptomatic HTLV-1 carriers. However, the roles of cellula r genes in HTLV-1-infected CD4+ T cells await discovery. We performed microarray analysis of CD4+ T cells from HAM/TSP p...
Source: PLoS Neglected Tropical Diseases - July 14, 2020 Category: Tropical Medicine Authors: Daisuke Kodama Source Type: research

Characterization of a dual-action adulticidal and larvicidal interfering RNA pesticide targeting the Shaker gene of multiple disease vector mosquitoes
by Keshava Mysore, Limb K. Hapairai, Longhua Sun, Ping Li, Chien-Wei Wang, Nicholas D. Scheel, Alexandra Lesnik, Jessica Igiede, Max P. Scheel, Na Wei, David W. Severson, Molly Duman-Scheel The existing mosquito pesticide repertoire faces great challenges to sustainability, and new classes of pesticides are vitally needed to address established and emerging mosquito-borne infectious diseases. RNA interference- (RNAi-) based pesticides are emerging as a promising new biorational mosqu ito control strategy. In this investigation, we describe characterization of an interfering RNA pesticide (IRP) corresponding to the mosquit...
Source: PLoS Neglected Tropical Diseases - July 19, 2020 Category: Tropical Medicine Authors: Keshava Mysore Source Type: research

Transcriptomic and small RNA response to Mayaro virus infection in Anopheles stephensi mosquitoes
In this study we detail the transcriptomic and small RNA responses ofAn.stephensi to infection with MAYV via infectious bloodmeal at 2, 7, and 14 days post infection (dpi). 487 unique transcripts were significantly regulated, 78 putative novel miRNAs were identified, and an siRNA response is observed targeting the MAYV genome. Gene ontology analysis of transcripts regulated at each timepoint shows a number of proteases regulated at 2 and 7 dpi, potentially representative of Toll or melanization pathway activation, and repression of pathways related to autophagy and apoptosis at 14 dpi. These findings provide a basic unders...
Source: PLoS Neglected Tropical Diseases - June 28, 2022 Category: Tropical Medicine Authors: Cory Henderson Source Type: research

 In vitro knockdown of Ts DNase II-7 suppresses Trichinella spiralis invasion into the host ’s intestinal epithelial cells
This study aimed to use RNA interference to verify our speculation thatTsDNase II-7 in 3-day old adultT.spiralis (Ad3) plays a role in intestinal invasion.TsDNase II-7-specific small interfering RNAs (siRNAs) were delivered into muscle larvae (MLs) to knockdownTsDNase II-7 expression by electroporation. Twenty-four hours later, the MLs transfected with 2 μM siRNA-841 exhibited decreased inTsDNase II-7 transcription and expression as compared to the control MLs. The knockdown ofTsDNase II-7 expression did not affect ML viability, and the low expression ofTsDNase II-7 still maintained in Ad3 recovered fromTsDNase II-7-RNAi-...
Source: PLoS Neglected Tropical Diseases - June 8, 2023 Category: Tropical Medicine Authors: Jing Wang Source Type: research

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