• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Effect of siRNA on Wisp-1 gene expression, proliferation, migration and adhesion of mouse hepatocellular carcinoma cells
Conclusions The inhibition of Wisp-1 expression can reduce the proliferation, migration and adhesion of mouse hepatocellular carcinoma cells, which is related to the AKT/glycogen synthase kinase-3β pathway. Wisp-1 gene may be the potential target to cure the hepatocellular carcinoma.
Source: Asian Pacific Journal of Tropical Medicine - October 4, 2015 Category: Tropical Medicine Source Type: research

Effect of survivin siRNA on biological behaviour of breast cancer MCF7 cells
Conclusions Interfering the expression of Survivin can inhibit the cell proliferation, migration and invasion, and promot apoptosis in MCF–7.
Source: Asian Pacific Journal of Tropical Medicine - April 27, 2015 Category: Tropical Medicine Source Type: research

Effect of siRNA interference on nerve growth factor in intervertebral disc inflammation rats
Conclusions These molecular biological results suggest that inflammatory factor IL-6 and IL-1β could stimulate NGF on intervertebral disc cells in vitro culture model and its efficiency is concentration dependent, while siRNA interference can inhibit the stimulation effect of IL-6 and IL-1β on intervertebral disc cell, which provides a new targets for the clinical treatment of discogenic low back pain.
Source: Asian Pacific Journal of Tropical Medicine - October 12, 2014 Category: Tropical Medicine Source Type: research

Lentivirus vectors construction of SiRNA targeting interference GPC3 gene and its biological effects on liver cancer cell lines Huh-7
Conclusions The targeted GPC3 siRNA can effectively inhibit the expression of GPC3.
Source: Asian Pacific Journal of Tropical Medicine - October 12, 2014 Category: Tropical Medicine Source Type: research

Influence on radiosensitivity of lung glandular cancer cells when ERCC1 gene silenced by targeted siRNA
Conclusions The radiation sensitivity of lung glandular tumor could be improved after the ERCC1 gene was silenced by siRNA.
Source: Asian Pacific Journal of Tropical Medicine - May 28, 2016 Category: Tropical Medicine Source Type: research

siRNA-Mediated Silencing of doublesex during Female Development of the Dengue Vector Mosquito Aedes aegypti
by Keshava Mysore, Longhua Sun, Michael Tomchaney, Gwyneth Sullivan, Haley Adams, Andres S. Piscoya, David W. Severson, Zainulabeuddin Syed, Molly Duman-Scheel The development of sex-specific traits, including the female-specific ability to bite humans and vector disease, is critical for vector mosquito reproduction and pathogen transmission. Doublesex (Dsx), a terminal transcription factor in the sex determination pathway, is known to regulate sex-specific gene expression during development of the dengue fever vector mosquito Aedes aegypti. Here, the effects of developmental siRNA-mediated dsx silencing were assessed in ...
Source: PLoS Neglected Tropical Diseases - November 6, 2015 Category: Tropical Medicine Authors: Keshava Mysore et al. Source Type: research

Expression of HIP/PAP in hepatocellular carcinoma and effect of siRNA on migration and invasion in HCC cells
Conclusions HIP/APA is overexpressed in HCC and contributes to the migration and invasion of HCC cells.
Source: Asian Pacific Journal of Tropical Medicine - September 25, 2015 Category: Tropical Medicine Source Type: research

In vitro inhibitory analysis of consensus siRNAs against NS3 gene of hepatitis C virus 1a genotype
Conclusions siRNAs directed against NS3 gene significantly decreased mRNA and protein expression in stable cell clones. Viral replication was also vividly decreased in serum infected Huh-7 cells. Stable Huh-7 cells expressing NS3 gene is helpful to develop anti-hepatitis C drug screening assays. siRNA therapeutic potential along with other anti-HCV agents can be considered against hepatitis C.
Source: Asian Pacific Journal of Tropical Medicine - August 9, 2017 Category: Tropical Medicine Source Type: research

In  vitro inhibitory analysis of consensus siRNAs against NS3 gene of hepatitis C virus 1a genotype
Conclusions siRNAs directed against NS3 gene significantly decreased mRNA and protein expression in stable cell clones. Viral replication was also vividly decreased in serum infected Huh-7 cells. Stable Huh-7 cells expressing NS3 gene is helpful to develop anti-hepatitis C drug screening assays. siRNA therapeutic potential along with other anti-HCV agents can be considered against hepatitis C.
Source: Asian Pacific Journal of Tropical Medicine - August 18, 2017 Category: Tropical Medicine Source Type: research

Mechanism of Wnt/β-catenin signaling pathway in enhanced malignant phenotype of non-small cell lung cancer induced by anti-angiogenesis therapy
Conclusions siRNA can significantly inhibit the expression of VEGF. For the anti-angiogenesis therapy, the inhibited expression of VEGF can activate the Wnt/β-catenin signaling pathway to cause the epithelial mesenchymal transition and then the enhanced malignant phenotype of non-small cell lung cancer.
Source: Asian Pacific Journal of Tropical Medicine - December 20, 2015 Category: Tropical Medicine Source Type: research

Characterization of the Zika virus induced small RNA response in < i > Aedes aegypti < /i > cells
by Margus Varjak, Claire L. Donald, Timothy J. Mottram, Vattipally B. Sreenu, Andres Merits, Kevin Maringer, Esther Schnettler, Alain Kohl RNA interference (RNAi) controls arbovirus infections in mosquitoes. Two different RNAi pathways are involved in antiviral responses: the PIWI-interacting RNA (piRNA) and exogenous short interfering RNA (exo-siRNA) pathways, which are characterized by the production of virus-derived small RNAs of 25–29 and 21 nucleotides, respectively. The exo-siRNA pathway is considered to be the key mosquito antiviral response mechanism. InAedes aegypti-derived cells, Zika virus (ZIKV)-specific siR...
Source: PLoS Neglected Tropical Diseases - October 17, 2017 Category: Tropical Medicine Authors: Margus Varjak Source Type: research

Molecular characterization of a < i > Trichinella spiralis < /i >  aspartic protease and its facilitation role in larval invasion of host intestinal epithelial cells
ConclusionsrTsASP2 possesses the enzymatic activity of native aspartic protease and facilitatesT.spiralis invasion of host IECs.
Source: PLoS Neglected Tropical Diseases - April 26, 2020 Category: Tropical Medicine Authors: Jia Xu Source Type: research

Effects of gene silencing of CypB on gastric cancer cells
Conclusions Gene silencing of CypB decreases gastric cancer cells proliferation and in vivo tumorigenesis. These findings indiccate CypB could be a potential biomarker and therapeutic target for gastric cancer.
Source: Asian Pacific Journal of Tropical Medicine - May 11, 2015 Category: Tropical Medicine Source Type: research

Study on the role of cathepsin B and JNK signaling pathway in the development of cerebral aneurysm
Conclusion After the attack of cerebral aneurysm, proteins like Cathepsin B, Caspase-3 and p-JNK are all involved in the apoptosis of VSMCs. This process may be realized by Cathepsin B which activates the apoptosis mechanism of Caspase-3 and mediate the apoptosis of VSMC through the JNK signaling pathway. Therefore, silencing Cathepsin B gene or inhibiting the conduction through JNK signaling pathway can mitigate the apoptosis of vascular smooth muscle cells in cerebral aneurysm.
Source: Asian Pacific Journal of Tropical Medicine - March 22, 2016 Category: Tropical Medicine Source Type: research

Inhibition of long non-coding RNA TUG1 on gastric cancer cell transference and invasion through regulating and controlling the expression of miR-144/c-Met axis
Conclusions lncRNA-TUG1 shows an up-regulated expression in GC tissue and that bears a correlation with clinicopathological features of malignant tumor. lncRNA-TUG1 can promote the transferring and invading capacity of GC by inhibiting the pathway of microRNA-144/c-Met.
Source: Asian Pacific Journal of Tropical Medicine - March 22, 2016 Category: Tropical Medicine Source Type: research

Pages: 1  2  3