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Total 41 results found since Jan 2013.

Effect of hypoxia on expression of placental trophoblast cells SATB1 and β-catenin and its correlation with the pathogenesis of preeclampsia
Conclusions Hypoxia can inhibit the expression of SATB1 and β-catenin in the pathogenesis of preeclampsia, which can affect the proliferation, apoptosis, migration and invasion of cells.
Source: Asian Pacific Journal of Tropical Medicine - April 19, 2016 Category: Tropical Medicine Source Type: research

The small non-coding RNA response to virus infection in the Leishmania vector Lutzomyia longipalpis 
by Fl ávia Viana Ferreira, Eric Roberto Guimarães Rocha Aguiar, Roenick Proveti Olmo, Karla Pollyanna Vieira de Oliveira, Emanuele Guimarães Silva, Maurício Roberto Viana Sant'Anna, Nelder de Figueiredo Gontijo, Erna Geessien Kroon, Jean Luc Imler, João Trindade Marques Sandflies are well known vectors forLeishmania but also transmit a number of arthropod-borne viruses (arboviruses). Few studies have addressed the interaction between sandflies and arboviruses. RNA interference (RNAi) mechanisms utilize small non-coding RNAs to regulate different aspects of host-pathogen interactions. The small interfering RNA (siRNA)...
Source: PLoS Neglected Tropical Diseases - June 4, 2018 Category: Tropical Medicine Authors: Fl ávia Viana Ferreira Source Type: research

PIWI silencing mechanism involving the retrotransposon nimbus orchestrates resistance to infection with Schistosoma mansoni in the snail vector, Biomphalaria glabrata 
Conclusions and significanceThese findings support a role for the interplay ofBgPiwi andnimbus in the epigenetic modulation of plasticity of resistance/susceptibility in the snail-schistosome relationship.
Source: PLoS Neglected Tropical Diseases - September 8, 2021 Category: Tropical Medicine Authors: Michael Smith Source Type: research

HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells
Conclusions Carcinoma HepG2 cell transfected high expression of HSP can promote the transformation of EMT, improve the expression of Vimentin, reduce the expression of E-cadherin, and inhibit apoptosis of cancer stem cells, which improve the invasive ability of cancer of the liver cells. While hsp-siRNA group presents opposite results. In summary, the expression of HSP is closely related to the occurrence, development and invasion of cancer of the liver tissue.
Source: Asian Pacific Journal of Tropical Medicine - May 11, 2015 Category: Tropical Medicine Source Type: research

Expression of MAPK1 in cervical cancer and effect of MAPK1 gene silencing on epithelial-mesenchymal transition, invasion and metastasis
Conclusions Because of the high expression of MAPK1 in the cervical cancer tissue, the interference in the expression of MAPK1 can significantly inhibit the invasion and metastasis of cervical cancer HeLa cells, which is related to the interference in the expression of MMPs/TIMP and Snail-mediated generation of EMT.
Source: Asian Pacific Journal of Tropical Medicine - October 9, 2015 Category: Tropical Medicine Source Type: research

The expression of MYH9 in osteosarcoma and its effect on the migration and invasion abilities of tumor cell
Conclusions MYH9 shows a trend of high expression in osteosarcoma tissues, and its high expression is associated with features such as tumor invasion and metastasis. The down-regulated MYH9 can realize an anti-tumor effect by inhibiting the migration and invasion of osteosarcoma cells.
Source: Asian Pacific Journal of Tropical Medicine - April 19, 2016 Category: Tropical Medicine Source Type: research

Targeted inhibition of Notch1 gene enhances the killing effects of Paclitaxel on triple-negative breast cancer cells
Conclusions Targeted inhibition of Notch1 gene may enhance the killing effects of paclitaxel on triple-negative breast cancer cells by up-regulating the expression of Caspase-3 and Caspase-9 and inhibiting the expression of Bcl-2.
Source: Asian Pacific Journal of Tropical Medicine - January 19, 2017 Category: Tropical Medicine Source Type: research

Targeted inhibition of Notch1 gene enhances the killing effects of paclitaxel on triple negative breast cancer cells
Conclusions Targeted inhibition of Notch1 gene may enhance the killing effects of paclitaxel on triple negative breast cancer cells by up-regulating the expression of Caspase-3 and Caspase-9 and inhibiting the expression of Bcl-2.
Source: Asian Pacific Journal of Tropical Medicine - January 24, 2017 Category: Tropical Medicine Source Type: research

RNA interference in Fasciola gigantica : Establishing and optimization of experimental RNAi in the newly excysted juveniles of the fluke
by Arun Anandanarayanan, Opinder Krishen Raina, Hniang Lalrinkima, Ajayta Rialch, Muthu Sankar, Anju Varghese Fasciolosis caused byFasciola gigantica is a neglected tropical disease but a constraint on the growth and productivity of cattle, buffaloes and sheep in the tropical countries of Asia and Africa. Resistance to commonly used anthelmintics inFasciola has increased the need to search for alternative therapeutic targets. RNA interference is the current tool of choice in the search for such targets inFasciola. The susceptibility of juvenileFasciola hepatica to double stranded (ds) RNA induced RNAi has been established...
Source: PLoS Neglected Tropical Diseases - December 12, 2017 Category: Tropical Medicine Authors: Arun Anandanarayanan Source Type: research

Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei 
Conclusions/SignificanceThe effects of the common nonsenseTLR5:c.1174C>T polymorphism on the host inflammatory response toB.pseudomallei may not be restricted to flagellin-driven pathways. Moreover, TLR5 may modulate TLR4-dependent cytokine production. While these results may have broader implications for the role of TLR5 in the innate immune response in melioidosis and other conditions, further studies of the mechanisms underlying these observations are required.
Source: PLoS Neglected Tropical Diseases - May 7, 2019 Category: Tropical Medicine Authors: Amy K. Dickey Source Type: research

Epigenetic regulation of defense genes by histone deacetylase1 in human cell line-derived macrophages promotes intracellular survival of Leishmania donovani 
by Gargi Roy, Harsimran Kaur Brar, Rohini Muthuswami, Rentala MadhubalaLeishmania donovani, an intracellular protozoan parasite upon infection, encounters a range of antimicrobial factors within the host cells. Consequently, the parasite has evolved mechanisms to evade this hostile defense system through inhibition of macrophage activation that, in turn, enables parasite replication and survival. There is growing evidence that epigenetic down-regulation of the host genome by intracellular pathogens leads to acute infection. Epigenetic modification is mediated by chromatin remodeling, histone modifications, or DNA methylati...
Source: PLoS Neglected Tropical Diseases - April 9, 2020 Category: Tropical Medicine Authors: Gargi Roy Source Type: research

 Trichinella spiralis : Knockdown of gamma interferon inducible lysosomal thiol reductase (GILT) results in the reduction of worm burden
by Hong Fei, Muhammad Ali-ul-Husnain Naqvi, Sana Zahra Naqvi, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng YanTrichinella spiralis is mammalian skeletal muscles parasite which may cause trichinellosis in animals and humans. Gamma interferon inducible lysosomal thiol reductase (GILT) is a widespread superfamily which plays key role in processing and presentation of MHC class II restricted antigen by catalyzing disulfide bond reduction. There are no reports about GILT inT.spiralis. In present study, GILT fromT.spiralis (Tsp-GILT) was cloned, analyzed by multiple-sequence alignment, and predicted by 3D structure model. Recomb...
Source: PLoS Neglected Tropical Diseases - November 30, 2021 Category: Tropical Medicine Authors: Hong Fei Source Type: research

Proteomics Profiling of Chikungunya-Infected Aedes albopictus C6/36 Cells Reveal Important Mosquito Cell Factors in Virus Replication
In this study, the CHIKV-infected C6/36 cells with differential cellular proteins expression were profiled using two-dimensional gel electrophoresis (2DE) coupled with the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). 2DE analysis on CHIKV-infected C6/36 cells has shown 23 mosquito cellular proteins that are differentially regulated, and which are involved diverse biological pathways, such as protein folding and metabolic processes. Among those identified mosquito proteins, spermatogenesis-associated factor, enolase phosphatase e-1 and chaperonin-60kD have been found to...
Source: PLoS Neglected Tropical Diseases - March 4, 2015 Category: Tropical Medicine Authors: Regina Ching Hua Lee et al. Source Type: research

Changes of TIZ expression in epithelial ovarian cancer cells
Conclusions The expression of TIZ can inhibit the proliferation of epithelial ovarian cancer cells.
Source: Asian Pacific Journal of Tropical Medicine - April 27, 2015 Category: Tropical Medicine Source Type: research

AEG-1 participates in high glucose-induced activation of Rho kinase and epithelial-mesenchymal transition in proximal tubular epithelial cells
Conclusions Our results show that AEG-1 acts a key role in high glucoseinduced activation of Rho kinase and EMT in HK-2 cells.
Source: Asian Pacific Journal of Tropical Medicine - November 17, 2015 Category: Tropical Medicine Source Type: research

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