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Specialty: Drugs & Pharmacology
Nutrition: Vitamin A

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Total 16 results found since Jan 2013.

A transcriptomics and molecular biology based investigation reveals the protective effect and mechanism of carnosol on t-BHP induced HRMECs via Nrf2 signaling pathway
In this study, carnosol was found to inhibit HRMECs injury induced by t-BHP. Transcriptomics and molecular biology illustrated that the mechanism was associated with oxidative stress, vascular system development, apoptosis, cell cycle, cell adhesion, cytoskeleton, and nitric oxide biosynthesis. Carnosol directly scavenged free radicals or activated the Nrf2 signaling pathway to alleviate HRMECs oxidative stress. ML385 pretreatment or Nrf2 small interference RNA (siRNA) inhibited the protective effect of carnosol on HRMECs injury. Moreover, the apoptosis and cell cycle arrest in HRMECs were suppressed by carnosol. Treatment...
Source: European Journal of Pharmacology - April 3, 2022 Category: Drugs & Pharmacology Authors: Yue Ren Yanan Liu Kaiyang Liu Zhan Shu Tianyi Lv Zijun Chen Wenqing Feng Yanling Zhang Source Type: research

ASAP Enhanced Delivery of siRNA to Retinal Ganglion Cells by Intravitreal Lipid Nanoparticles of Positive Charge
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.0c00992
Source: Molecular Pharmaceutics - December 9, 2020 Category: Drugs & Pharmacology Authors: Xiaonan Huang and Ying Chau Source Type: research

C-CBL is required for inhibition of angiogenesis through modulating JAK2/STAT3 activity in ROP development.
CONCLUSION: We found that C-CBL is required for anti-neovascularization process in ROP development by inhibiting JAK2/STAT3-dependent angiogenesis. Thus, our finding strongly suggest that C-CBL may be a potential novel therapeutic target for treating ROP. PMID: 33125970 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 27, 2020 Category: Drugs & Pharmacology Authors: Chen S, Sun Q, Sun D, Willette-Brown J, Anderson MJ, Gu Q, Lewandoski M, Hu Y, Zhu F, Wei F, Zhang J Tags: Biomed Pharmacother Source Type: research

MTIM affects retinal ganglion cells through PI3K/AKT signaling pathway.
CONCLUSIONS: Up-regulation of MT1M can inhibit RGC cell apoptosis and inflammation, and promote RGC cell proliferation through the PI3K/AKT signaling pathway. PMID: 32495853 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 5, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Mechanism of FGF7 gene silencing in regulating viability, apoptosis, invasion of retinoblastoma cell line HXO-Rb44 and angiogenesis.
CONCLUSIONS: FGF7 gene silencing can inhibit the viability and invasion of RB cells and the expression of angiogenesis-related factors and can promote RB apoptosis. PMID: 32329827 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - April 26, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
CONCLUSIONS: MiR-375 inhibitors are able to reduce blood glucose, retinal permeability, and optic ganglion apoptosis in rats with DR, and the mechanism of action may be related to the regulation on the Ndrg2/IL-6/STAT3 signaling pathway. PMID: 32196570 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - March 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Knockdown of ALK7 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.
Abstract Diabetic retinopathy (DR) is one of the diabetic complications associated with hyperglycemia-mediated oxidative stress. Activin receptor-like kinase 7 (ALK7) has been proven to be a potential therapeutic approach for diabetic cardiomyopathy, which is another diabetic complication. However, the role of ALK7 in DR remains unclear. In the current study, ALK7 was found to be up-regulated in clinical samples from DR patients and high glucose (HG)-induced human retinal pigment epithelial cells (ARPE-19). In vitro studies demonstrated that knockdown of ALK7 in ARPE-19 cells through transfection with siRNA-ALK7 (...
Source: Clinical and Experimental Pharmacology and Physiology - October 13, 2019 Category: Drugs & Pharmacology Authors: Shi Q, Dong X, Zhang M, Cheng Y, Pei C Tags: Clin Exp Pharmacol Physiol Source Type: research

LncRNA ANRIL knockdown ameliorates retinopathy in diabetic rats by inhibiting the NF- κB pathway.
CONCLUSIONS: LncRNA ANRIL knockdown can significantly ameliorate the retinopathy in diabetic rats by blocking the nuclear factor-kappa B (NF-κB) signaling pathway. PMID: 31599399 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 12, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase I.
In conclusion, MGO caused the injury of retinal endothelial cells through induction of mitochondrial dysfunction and mitochondrial fission, the treatment of Tan IIa ameliorated mitochondrial dysfunction and fission induced by AGEs through enhancing GLO1. PMID: 31136758 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - May 24, 2019 Category: Drugs & Pharmacology Authors: Qian S, Qian Y, Huo D, Wang S, Qian Q Tags: Eur J Pharmacol Source Type: research

Vitamin D receptor regulates high-level glucose induced retinal ganglion cell damage through STAT3 pathway.
CONCLUSIONS: Inhibition of VDR exerts a protective role in high-level glucose induced RGCs damage by activating the STAT3 pathway. PMID: 30468500 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

IGF-1 regulates Ang II and VEGF signaling pathways in retinal neovascularization.
CONCLUSIONS: The occurrence of retinal neovascularization is related to the reduction of IGF-1 expression and the increase of Ang II and VEGF. PMID: 30338783 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 21, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway.
In conclusion, ADMA contributes to the neovascularization of retina in diabetic mellitus, which is regulated by ephrinB2. PMID: 29777874 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - May 16, 2018 Category: Drugs & Pharmacology Authors: Du MR, Yan L, Li NS, Wang YJ, Zhou T, Jiang JL Tags: Vascul Pharmacol Source Type: research

Inhibition of BMP4 and Alpha Smooth Muscle Actin Expression in LX-2 Hepatic Stellate Cells by BMP4-siRNA Lipid Based Nanoparticle.
Conclusion: VA-coated liposomes were successfully designed to deliver BMP4-siRNA to specifically target HSC. The novel delivery system discussed herein may serve as a potential therapeutic strategy for the treatment of liver fibrosis in the future. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29578859 [PubMed - in process]
Source: J Pharm Pharm Sci - March 28, 2018 Category: Drugs & Pharmacology Authors: Omar R, Yang J, Alrushaid S, Burczynski FJ, Minuk GY, Gong Y Tags: J Pharm Pharm Sci Source Type: research

Long non-coding RNA GAS5 contributed to the development of glaucoma via regulating the TGF- β signaling pathway.
CONCLUSIONS: In our study, we found that down-regulation of lncRNA GAS5 may maintain retinal ganglion cell survival in glaucoma through the activation of TGF-β pathway to promote cell proliferation and differentiation. PMID: 29509235 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 8, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research