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Total 20 results found since Jan 2013.
Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid‐Associated Osteonecrosis in Rabbits
This study was designed to prove our hypothesis that blocking VEGF‐Src signaling pathway by specific Src siRNA was able to prevent destructive repair in a SAON rabbit model. Destructive repair in SAON was induced in rabbits. At 2, 4, 6 weeks after SAON induction, VEGF, anti‐VEGF, Src siRNA, Src siRNA + VEGF, control siRNA and saline were intramedullary injected into proximal femora for each group, respectively. Vascularization and permeability were quantified by dynamic contrast‐enhanced (DCE) MRI. At week 6 after SAON induction, proximal femora were dissected for micro‐CT‐based trabecular architecture with f...
Source: Journal of Bone and Mineral Research - April 27, 2015 Category: Orthopaedics Authors: Li‐zhen Zheng, Hui‐juan Cao, Shi‐hui Chen, Tao Tang, Wei‐min Fu, Le Huang, Dick Ho Kiu Chow, Yi‐xiang Wang, James Francis Griffith, Wei He, Hong Zhou, De‐wei Zhao, Ge Zhang, Xin‐luan Wang, Ling Qin Tags: Original Article Source Type: research
Role of endogenous insulin gene enhancer protein ISL-1 in angiogenesis.
CONCLUSIONS: Reducing the expression of endogenous Islet-1 inhibits proliferation, migration, and tube formation in vascular endothelial cells in vitro and suppresses retinal angiogenesis in vivo. Endogenous Islet-1 regulates angiogenesis via VEGF.
PMID: 27994436 [PubMed - in process]
Source: Molecular Vision - December 22, 2016 Category: Molecular Biology Tags: Mol Vis Source Type: research
Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood-brain barrier injury through the Wnt/ β-catenin signalling pathway
CONCLUSION: This study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced BBB injury, and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/β-catenin signalling pathway under ischemic conditions.PMID:34857032 | DOI:10.1186/s40779-021-00356-x
Source: Cell Research - December 3, 2021 Category: Cytology Authors: Xing-Yong Chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin Yan-Guang Mao Xiao-Hua Yu Yin-Zhou Wang Source Type: research
Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood –brain barrier injury through the Wnt/β-catenin signalling pathway
ConclusionThis study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced BBB injury, and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/ β-catenin signalling pathway under ischemic conditions.
Source: Military Medical Research - December 3, 2021 Category: International Medicine & Public Health Source Type: research
Inhibition of YAP ameliorates choroidal neovascularization via inhibiting endothelial cell proliferation.
Conclusions: This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment.
PMID: 29422766 [PubMed - in process]
Source: Molecular Vision - February 11, 2018 Category: Molecular Biology Tags: Mol Vis Source Type: research
PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression.
CONCLUSIONS: PKR promotes CNV formation via the PI3K/Akt signaling pathway in VEGF expression. Additionally, the anti-PKR monoclonal antibody significantly decreased CNV in a mouse model, showing the antibody may have therapeutic potential in human CNV.
PMID: 27994435 [PubMed - in process]
Source: Molecular Vision - December 22, 2016 Category: Molecular Biology Tags: Mol Vis Source Type: research
Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function
Exp Eye Res. 2022 May 29:109129. doi: 10.1016/j.exer.2022.109129. Online ahead of print.ABSTRACTPreservation of retinal barrier function is critical to maintenance of retinal health. Therefore, it is not surprising that loss of barrier integrity is a pathologic feature common to degenerative retinal diseases such as diabetic retinopathy. Our prior studies demonstrate the importance of hydroxycarboxylic acid receptor 2/GPR109A (HCAR2/GPR109A) expression in the retinal pigment epithelium (RPE) to outer retinal barrier integrity. However, whether HCAR2/GPR109A is expressed in retinal endothelial cells and has a similar relati...
Source: Experimental Eye Research - June 1, 2022 Category: Opthalmology Authors: Ammar A Abdelrahman Folami L Powell Ravirajsinh N Jadeja Malita A Jones Menaka C Thounaojam Manuela Bartoli Mohamed Al-Shabrawey Pamela M Martin Source Type: research
SIRT3 attenuates coronary atherosclerosis in diabetic patients by regulating endothelial cell function
CONCLUSION: SIRT3 was associated with the progression of atherosclerosis in T2DM patients through upregulation of PPAR-α and eNOS and downregulation of iNOS, which are involved in endothelial dysfunction under hyperglycemic conditions.PMID:35791925 | DOI:10.1002/jcla.24586
Source: Atherosclerosis - July 6, 2022 Category: Cardiology Authors: Huiping Gong Jing Liu Zhiwei Xue Wenwen Wang Cuicui Li Fanfan Xu Yimeng Du Xiaona Lyu Source Type: research
Nestin contributes to laser choroidal and retinal neovascularization
CONCLUSIONS: Our results confirmed the presence of nestin in glial (e.g., astrocytes), reactive Müller, and endothelial cells. They demonstrated their critical involvement in a rat model of retinal and choroidal neovascularization experimentally induced using ocular laser impacts.PMID:36284669 | PMC:PMC9514549
Source: Molecular Vision - October 26, 2022 Category: Molecular Biology Authors: Sofiane Miloudi Maud Valensi Mohamed El Sanharawi Marc M Abitbol Francine Behar-Cohen Claudine Versaux-Botteri Source Type: research
