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The effect of silencing the Tip60 gene on the response to radiotherapy in breast cancer cells
In this study, for the first time, the role of the silenced and active Tip60 gene in response to radiotherapy in MDA-MB-231 and MCF-7 cells was investigated. For this purpose, the Tip60 gene was silenced by applying siRNA to the cell lines and UV was applied. In the study, cytotoxicity and DNA breaks were measured by MTT and COMET methods, and mRNA and protein expression values were measured by PCR and Raman spectrophotometer in silenced, unsilenced, UV-treated, and non-UV-treated cell lines. According to the results of the study, increased DNA damage was observed in MCF-7 cell lines in which the Tip60 gene was silenced, a...
Source: Breast - April 17, 2023 Category: Cancer & Oncology Authors: Ece Miser-Saliho ğlu Bensu Karahalil Meri ç Arda Eşmakaya U ğur Tamer Sevgi Yardim-Akaydin Source Type: research

Suppression of GCH1 Sensitizes Ovarian Cancer and Breast Cancer to PARP Inhibitor
CONCLUSION: Our results illustrated that PARP inhibitors promote GCH1 expression via the JAK-STAT pathway. We also elucidated the potential relationship between GCH1 and the homologous recombination repair pathway and proposed a combination regimen of GCH1 suppression with PARP inhibitors in breast and ovarian cancers.PMID:36793373 | PMC:PMC9925261 | DOI:10.1155/2023/1453739
Source: Journal of Oncology - February 16, 2023 Category: Cancer & Oncology Authors: Siyuan Wang Yu Xia Pu Huang Cheng Xu Yiyu Qian Tian Fang Qinglei Gao Source Type: research

The linker of nucleoskeleton and cytoskeleton complex is required for X-ray-induced epithelial-mesenchymal transition
This study focused on epithelial-mesenchymal transition (EMT), which contributes to cell migration. Hence, the present study aimed to examine whether sublethal-dose X-irradiation induces EMT and whether LINC complex component SUN1 is involved in low-dose X-ray-induced EMT. This study showed that low-dose (0.5 Gy or 2 Gy) X-irradiation induced EMT in human breast cancer MDA-MB-231 cells. Additionally, X-irradiation increased the expression of SUN1. Therefore, SUN1 was depleted using siRNA. In SUN1-depleted cells, low-dose X-irradiation did not induce EMT. In addition, although the SUN1 splicing variant SUN1_916-depleted cel...
Source: Cell Research - January 25, 2023 Category: Cytology Authors: Hiromasa Imaizumi Kazumasa Minami Miki Hieda Naomasa Narihiro Masahiko Koizumi Source Type: research

CDK4/6 Inhibition and Radiation as a Treatment Strategy to Improve Local Disease Control in Breast Cancers With Poor Prognoses
CONCLUSION: RB loss mitigates CDK4/6 inhibitor-mediated radiosensitization of both ER+ and TNBC cells. Loss of RB expression prevents CDK4/6i-mediated radiosensitization, suggesting that RB expression may be a valuable clinical biomarker to predict efficacy of CDK4/6i + RT in future clinical trials. Our data also provide the preclinical rationale for CDK4/6i with RT not just in ER+ BC, but also in women with TNBC that express RB.PMID:34700581 | DOI:10.1016/j.ijrobp.2021.07.143
Source: Ann Oncol - October 27, 2021 Category: Cancer & Oncology Authors: A Pesch N Hirsh A R Michmerhuizen B Chandler K Wilder-Romans L Lerner M Liu D F Hayes E Cobain L J Pierce J Rae C Speers Source Type: research

KMT2C is a potential biomarker of prognosis and chemotherapy sensitivity in breast cancer
CONCLUSION: We conclude that KMT2C could serve as a potential biomarker of prognosis and chemotherapy sensitivity by affecting the DNA damage repair-related genes of breast cancer.PMID:34240274 | DOI:10.1007/s10549-021-06325-1
Source: Cell Research - July 9, 2021 Category: Cytology Authors: Xinhua Liu Rongfang Qiu Min Xu Miaomiao Meng Siyu Zhao Jiansong Ji Yang Yang Source Type: research

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