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Lowered expression of CCN5 in endometriotic tissues promotes proliferation, migration and invasion of endometrial stromal cells
CONCLUSION: CCN5 can regulate the proliferation, migration and invasion of HESCs and thus plays an important role in EMT of HESCs, suggesting the potential of CCN5 as a therapeutic target for endometriosis.PMID:35249874 | PMC:PMC8901405 | DOI:10.12122/j.issn.1673-4254.2022.01.10
Source: Journal of Southern Medical University - March 7, 2022 Category: Universities & Medical Training Authors: H Cai M Liu M Lin H Li L Shen S Quan Source Type: research

Serum level of visfatin can reflect the severity of inflammation in patients with acute cholecystitis.
Conclusion: Taken together, we concluded that visfatin is a pro-inflammatory mediators that is upregulated during acute cholecystitis and is expected to be increased within a short time after inflammation. Therefore, measuring the serum level of visfatin would be helpful in predicting the inflammatory severity in the patients with acute cholecystitis. PMID: 32676479 [PubMed]
Source: Annals of Surgical Treatment and Research - July 18, 2020 Category: Surgery Tags: Ann Surg Treat Res Source Type: research

Fibrinogen alpha chain is up-regulated and affects the pathogenesis of endometriosis
ConclusionsHigh FGA expression in endometriosis was closely related to disease severity and affected cell adhesion, migration and invasion, which might play an important role in the pathogenesis of endometriosis.
Source: Reproductive BioMedicine Online - December 12, 2019 Category: Reproduction Medicine Source Type: research

Fibrinogen alpha chain is upregulated and affects the pathogenesis of endometriosis
ConclusionsHigh expression of FGA in EM was closely related to disease severity and affected cell adhesion, migration, and invasion, which might play an important role in the pathogenesis of EM.
Source: Reproductive BioMedicine Online - August 21, 2019 Category: Reproduction Medicine Source Type: research

Potential roles of aquaporin 9 in the pathogenesis of endometriosis
In this study, tissue samples were obtained from women undergoing laparoscopic surgery for endometriosis and other benign conditions. Analysis of expressions of AQP subtypes in eutopic and ectopic endometrium of patients with endometriosis (Eu-EMS and Ect-EMS, respectively) and eutopic endometrium of control patients without endometriosis (Eu-CTL) were performed using the NanoString nCounter System and western blotting. Human endometrial stromal cells (HESCs) were cultured and transfected with the siRNA of the AQP of interest. Among the AQP1 –9 subtypes, endometrial expression of AQP2 and AQP8 was significantly increased...
Source: Molecular Human Reproduction - May 9, 2019 Category: Molecular Biology Source Type: research

Methylxanthine derivatives promote autophagy in gastric cancer cells targeting PTEN
This study investigated the impacts of caffeine and theophylline on gastric cancer cell apoptosis and autophagy using a gastric cancer cell line (MGC-803) and a nude mouse model. Peritumoural and tumour tissues were collected from five patients diagnosed with gastric carcinoma who underwent laparoscopic radical gastrectomy at our hospital. Autophagy was suppressed in gastric cancer tumour tissue compared with peritumoural tissue. In vitro, both caffeine and theophylline effectively suppressed MGC-803 cell proliferation and migration and induced autophagy. To assess the involvement of PTEN in caffeine-mediated and theophyll...
Source: Anti-Cancer Drugs - March 16, 2019 Category: Cancer & Oncology Tags: PRECLINICAL REPORTS Source Type: research

Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis
This study was funded by the Academy of Finland and by Tekes: Finnish Funding Agency for Innovation. The authors have no conflict of interest to declare.
Source: Human Reproduction - February 15, 2018 Category: Reproduction Medicine Source Type: research

Expression of MicroRNA-448 and SIRT1 and Prognosis of Obese Type 2 Diabetic Mellitus Patients After Laparoscopic Bariatric Surgery
Conclusion: The results demonstrated that miR-448 and its target gene SIRT1 can serve as prognostic indicators for obese T2DM patients after laparoscopic bariatric surgery.Cell Physiol Biochem 2018;45:935 –950
Source: Cellular Physiology and Biochemistry - February 9, 2018 Category: Cytology Source Type: research

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