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Total 51 results found since Jan 2013.
Exosomal lnc-CDHR derived from human umbilical cord mesenchymal stem cells attenuates peritoneal epithelial-mesenchymal transition through AKT/FOXO pathway
CONCLUSIONS: Exosomal lnc-CDHR derived from hUMSCs may competitively bind to miR-3149 to regulate suppression on target PTEN genes and alleviate EMT of HMrSV5 through AKT/FOXO pathway.PMID:37466443 | DOI:10.18632/aging.204883
Source: Aging - July 19, 2023 Category: Biomedical Science Authors: Taiwei Jiao Yuling Huang Haiyan Sun Lina Yang Source Type: research
Mechanisms of human umbilical cord mesenchymal stem cells-derived exosomal lncRNA GAS5 in alleviating EMT of HPMCs via Wnt/ β-catenin signaling pathway
CONCLUSIONS: Exosomes from the hUC-MSCs-CM could alleviate the EMT of HPMCs induced by HG via regulating lncRNA GAS5/miR-21/PTEN through the Wnt/β-catenin signaling pathway.PMID:37229651 | DOI:10.18632/aging.204719
Source: Aging - May 25, 2023 Category: Biomedical Science Authors: Yuling Huang Jianfei Ma Yi Fan Lina Yang Source Type: research
COMMD5 is involved in the mechanisms of hypotension after parathyroidectomy in patients receiving hemodialysis
CONCLUSIONS: Serum COMMD5 levels were increased after PTx in SHPT patients. COMMD5 promoted high expression of ANP and eNOS in endothelial cells, leading to vasodilation and resulting in hypotension.PMID:36804542 | DOI:10.1016/j.ejphar.2023.175596
Source: European Journal of Pharmacology - February 22, 2023 Category: Drugs & Pharmacology Authors: Bohou Li Xueqin Chen Juan Hu Guibao Ke Nan Jiang Fengxia Zhang Zhiwen Lian Sichun Wen Qiong Wu Yubin Xia Hong Zhang Sujuan Kuang Lixia Xu Chunyu Deng Shuangxin Liu Source Type: research
STAT3 signaling mediates peritoneal fibrosis by activating hyperglycolysis
CONCLUSIONS: si-STAT3 attenuated the HG-induced EMT and hyperglycolysis, and the overexpression of STAT3 could induce EMT in HMrSV5 cells. 3PO could markedly attenuate HG-induced EMT by decreasing PFKEB3 in HMrSV5 cells. In addition, we demonstrated that inhibiting STAT3 signaling or peritoneal hyperglycolysis could attenuate peritoneal fibrosis and angiogenesis in vivo. Our findings linked the STAT3/PFKFB3 signaling to the development of PF. HG/STAT3/PFKFB3 might promote the progression of PF through regulating profibrosis and angiogenesis.PMID:36398234 | PMC:PMC9641446
Source: American Journal of Translational Research - November 18, 2022 Category: Research Authors: Jiao Fu Nan Li Mengmeng He Dake Huang Pei Zhang Source Type: research
