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Experimental acute kidney injury
Conclusions: WNT10A expression may promote fibrotic progression and kidney dysfunction in AIN. Blockade of WNT10A expression may be a feasible therapeutic strategy against kidney fibrosis.
Source: Nephrology Dialysis Transplantation - May 21, 2014 Category: Urology & Nephrology Authors: Kuma, A., Yamada, S., Miyamoto, T., Serino, R., Tamura, M., Otsuji, Y., Kohno, K., Cho, W. Y., Kim, M.-G., Jo, S.-K., Kim, H. K., Jado, J. C., Humanes, B., Lopez-Parra, V., Camano, S., Lara, J. M., Cercenado, E., Tejedor, A., Lazaro, A., Jansen, M., Caste Tags: Sunday, June 1st, 2014: Posters Source Type: research

Cell signalling and apoptosis
Conclusions: These results suggest that activation of S1P signaling mediated by S1PR-3 results in chronic pathological fibrosis, such as in chronic kidney disease (CKD).
Source: Nephrology Dialysis Transplantation - May 21, 2014 Category: Urology & Nephrology Authors: Shiohira, S., Yoshida, T., Sugiura, H., Nishida, M., Nitta, K., Tsuchiya, K., Grampp, S., Goppelt-Strube, M., Eckardt, K. U., Schodel, J., Kang, S. W., Kim, Y., Seo, S.-K., Kim, T., Ong, S., Yang, W. S., Han, N. J., Lee, J. M., Baek, C. H., Park, S.-K., K Tags: Monday, June 2nd, 2014: Posters Source Type: research

Lipopolysaccharide (LPS)-induced autophagy is involved in the restriction of Escherichia coli in peritoneal mesothelial cells
Conclusions: Our findings demonstrated for the first time that LPS-induced autophagy in peritoneal mesothelial cells could enhance the intracellular bactericidal activity and the co-localization of E.coli with autophagosomes. The activation of TLR4 signaling was involved in this process. These results indicate that LPS-induced autophagy may be a cell-autonomous defense mechanism triggered in peritoneal mesothelial cells in response to E.coli infection.
Source: BMC Microbiology - Latest articles - November 13, 2013 Category: Microbiology Authors: Juan WangXiaoran FengYoujia ZengJinjin FanJuan WuZhijian LiXinhui LiuRong HuangFengxian HuangXueqing YuXiao Yang Source Type: research

Tubular ischemia and toxicity
Conclusions: EPC-derived EVs protect the kidney from ischemic AKI by delivering mRNAs coding for factor H, DAF and CD59 to injured tubular epithelial and endothelial cells. These results confirmed previous data on the relevance of complement inhibition after kidney IRI and suggest the potential use of EPC-derived EVs as therapeutic option to avoid delayed graft function after kidney transplantation.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Cantaluppi, V., Medica, D., Figliolini, F., Gatti, S., Bruno, S., Quercia, A. D., Dellepiane, S., Biancone, L., Tetta, C., Camussi, G., Zhou, L., Dai, X., Feng, M., Huang, X., Fu, P., Lan, H. Y., de Ramon, L., Ripoll, E., Luzardo, L., Merino, A., Bolanos, Tags: Abstracts Source Type: research

Cell signalling
Conclusions: Taken together, it is likely that klotho protects against renal fibrotic process accompanied by down-regulation of fibrotic markers, counteracting to TGF-β, and one of possible mechanism mediating translocation of Na/K ATPase, resulting in Ca+ channel stabilization/alternation of Ca+ ion concentration. Klotho should be involved in the accentuation of the progression of renal fibrosis in CKD.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Tsuchiya, K., Shiohira, S., Sugiura, H., Suzuki, M., Okano, K., Nitta, K., Kaesler, N., Immendorf, S., Ouyang, C., Carmeliet, P., Floege, J., Kruger, T., Schlieper, G., Georgescu, A., Kalucka, J., Olbrich, S., Baumgartl, J., Hackenbeck, T., Eckardt, K.-U. Tags: Abstracts Source Type: research

Modulation of A-type K(+) channels by the short-chain cobrotoxin through the protein kinase C-delta isoform decreases membrane excitability in dorsal root ganglion neurons.
In this study, we identified the functional role of cobrotoxin, the short-chain α-neurotoxin isolated from Naja atra venom, which acts in the regulation of the transient A-type K(+) currents (I(A)) and membrane excitability in dorsal root ganglion (DRG) neurons via the activation of the muscarinic M3 receptor (M3R). Our results showed that cobrotoxin increased I(A) in a concentration-dependent manner, whereas the sustained delayed rectifier K(+) currents (I(DR)) were not affected. Cobrotoxin did not affect the activation of I(A) markedly, however, it shifted the inactivation curve significantly in the depolarizing directi...
Source: Biochemical Pharmacology - February 19, 2013 Category: Drugs & Pharmacology Authors: Guo Q, Jiang YJ, Jin H, Jiang XH, Gu B, Zhang YM, Wang JG, Qin ZH, Tao J Tags: Biochem Pharmacol Source Type: research

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