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CYP2E1 triggered GRP78/ATF6/CHOP signalling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma
Arch Biochem Biophys. 2023 Jul 25:109701. doi: 10.1016/j.abb.2023.109701. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. Cytochrome P450 2E1 (CYP2E1) is an enzyme, primarily involved in the metabolism of xenobiotics and procarcinogens. The present study was designed to investigate the potential role of CYP2E1 triggered endoplasmic reticulum stress in the progression of HCC through inhibition of apoptosis. In vitro CYP2E1 promotes HepG2 cell migration, reduced chromatin condensation, enhanced intracellular ROS accumulation and induce cell cycle progressio...
Source: Archives of Biochemistry and Biophysics - July 27, 2023 Category: Biochemistry Authors: Sharmeen Ishteyaque Karan Singh Yadav Smriti Verma Kaveri R Washimkar Madhav Nilakanth Mugale Source Type: research

Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake
Int J Biol Macromol. 2021 Oct 18:S0141-8130(21)02211-X. doi: 10.1016/j.ijbiomac.2021.10.058. Online ahead of print.ABSTRACTAscorbic acid (AA) uptake in neurons occurs via a Na+-dependent carrier-mediated process mediated by the sodium-dependent vitamin C transporter-2 (SVCT2). Relatively little information is available concerning the network of interacting proteins that support human (h)SVCT2 trafficking and cell surface expression in neuronal cells. Here we identified the synaptogenic adhesion protein, calsyntenin-3 (CLSTN3) as an hSVCT2 interacting protein from yeast two-hybrid (Y2H) screening of a human adult brain cDNA...
Source: International Journal of Biological Macromolecules - October 21, 2021 Category: Biochemistry Authors: Veedamali S Subramanian Trevor Teafatiller Janielle Vidal Gihan S Gunaratne Carlos J Rodriguez-Ortiz Masashi Kitazawa Jonathan S Marchant Source Type: research

The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration
BMB Rep. 2021 Jan 7:5184. Online ahead of print.ABSTRACTVoltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti-oxidants, such as N-acetylcysteine or ascorbic acid, implying that the hi...
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Hyun Woo Park Min Seok Song Hun Ju Sim Pan Dong Ryu So Yeong Lee Source Type: research

The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration.
Abstract Voltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti-oxidants, such as N-acetylcysteine or ascorbic acid, implying that the highly expressed Kv2.1 could detect reac...
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Park HW, Song MS, Sim HJ, Ryu PD, Lee SY Tags: BMB Rep Source Type: research

Soluble klotho regulates bone differentiation by upregulating expression of the transcription factor EGR ‐1
AbstractKlotho is a transmembrane protein known to regulate aging and lifespan. Soluble klotho (sKl), a truncated form of klotho, regulates various cell signaling pathways, including bone development. Here, we investigated the relationship between sKl and the zinc ‐finger transcription factor early growth response protein 1 (EGR‐1) on bone formation. We find that sKl induces the expression of EGR‐1 mRNA and protein. Through mutational analysis, we identify the 130 bp region on the EGR‐1 promoter that is responsive to sKl overexpression. Additionally, sKl induces the expression of markers of bone differentiation (BM...
Source: FEBS Letters - September 18, 2019 Category: Biochemistry Authors: Nguyen Khanh Toan, Nguyen Chi Tai, Soo ‐A Kim, Sang‐Gun Ahn Tags: RESEARCH ARTICLES Source Type: research

TXNIP-mediated nuclear factor- κB signaling pathway and intracellular shifting of TXNIP in uric acid-induced NLRP3 inflammasome.
CONCLUSION: This study showed that activation of MSU-induced NLRP3 inflammasome requires TXNIP-mediated NF-κB signaling pathway and intracellular TXNIP shifting. PMID: 30833078 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - February 28, 2019 Category: Biochemistry Authors: Kim SK, Choe JY, Park KY Tags: Biochem Biophys Res Commun Source Type: research