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Specialty: Biochemistry
Nutrition: Calcium

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Total 38 results found since Jan 2013.

Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2
Biochim Biophys Acta Mol Cell Res. 2023 Mar 18:119466. doi: 10.1016/j.bbamcr.2023.119466. Online ahead of print.ABSTRACTDistorted neuronal calcium signaling has been reported in many neurodegenerative disorders, including different types of spinocerebellar ataxias (SCAs). Cerebellar Purkinje cells (PCs) are primarily affected in SCAs and the disturbances in the calcium homeostasis were observed in SCA PCs. Our previous results have revealed that 3,5-dihydroxyphenylglycine (DHPG) induced greater calcium responses in SCA2-58Q PC cultures than in wild type (WT) PC cultures. Here we observed that glutamate-induced calcium rele...
Source: Biochimica et Biophysica Acta - March 20, 2023 Category: Biochemistry Authors: Polina A Egorova Ksenia S Marinina Ilya B Bezprozvanny Source Type: research

25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1) induces ectopic calcification
J Clin Biochem Nutr. 2022 Sep;71(2):103-111. doi: 10.3164/jcbn.22-16. Epub 2022 Jun 4.ABSTRACTVascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arte...
Source: Clinical Biochemistry - October 10, 2022 Category: Biochemistry Authors: Yilimulati Yimamu Ayako Ohtani Yuichiro Takei Airi Furuichi Yuki Kamei Hisami Yamanaka-Okumura Hirokazu Ohminami Masashi Masuda Makoto Miyazaki Hironori Yamamoto Yutaka Taketani Source Type: research

Kalirin mediates Rac1 activation downstream of calcium/calmodulin ‐dependent protein kinase II to stimulate glucose uptake during muscle contraction
In this study, we investigated the role of calcium/calmodulin-dependent protein kinase II (CaMKII) in contraction-stimulated glucose uptake in skeletal muscle. C2C12 myotubes were contracted by electrical pulse stimulation (EPS), and treadmill running was used to exercise mice. The activities of CaMKII, the small G protein Rac1, and the Rac1 effector kinase PAK1 were elevated in muscle by running exercise or EPS, while they were lowered by the CaMKII inhibitor KN-93 and/or small interfering RNA (siRNA)-mediated knockdown. EPS induced the mRNA and protein expression of the Rac1-GEF Kalirin in a CaMKII-dependent manner. EPS-...
Source: FEBS Letters - June 30, 2022 Category: Biochemistry Authors: Sasa Liu, Rui Qi, Juan Zhang, Chang Zhang, Liming Chen, Zhi Yao, Wenyan Niu Tags: Research Article Source Type: research

Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress
Biochem Biophys Res Commun. 2022 Mar 31;608:156-162. doi: 10.1016/j.bbrc.2022.03.156. Online ahead of print.ABSTRACTCalpains are cysteine proteases activated in response to intracellular calcium signaling. Activated calpains regulate various cellular functions by degrading substrate molecules in a site-specific manner. Although most calpains are localized in the cytosol, we previously reported that calpain-5 exists in the mitochondria. The mitochondrial calpain-5 is activated during endoplasmic reticulum (ER) stress. However, the substrate of calpain-5, as well as the physiological significance of calpain-5 activation, has...
Source: Biochemical and Biophysical Research communications - April 10, 2022 Category: Biochemistry Authors: Yusaku Chukai Ginga Ito Masahide Konno Yuri Sakata Taku Ozaki Source Type: research

SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells
Biochem Biophys Res Commun. 2022 Mar 25;607:44-48. doi: 10.1016/j.bbrc.2022.03.121. Online ahead of print.ABSTRACTIn pulmonary arterial smooth muscle cells (PASMCs), an increase in the cytosolic Ca2+ concentration ([Ca2+]cyt) is involved in many physiological processes such as cell contraction and proliferation. However, chronic [Ca2+]cyt increases cause pulmonary vasoconstriction and vascular remodeling, resulting in pulmonary arterial hypertension (PAH). Therefore, [Ca2+]cyt signaling plays a substantial role in the regulation of physiological and pathological functions in PASMCs. In the present study, the effects of SKF...
Source: Biochemical and Biophysical Research communications - April 2, 2022 Category: Biochemistry Authors: Riko Miyaki Aya Yamamura Akiko Kawade Moe Fujiwara Rubii Kondo Yoshiaki Suzuki Hisao Yamamura Source Type: research

RNA-Seq reveals the potential molecular mechanisms of bovine KLF6 gene in the regulation of adipogenesis
This study aims to investigate the influence of KLF6 (Kruppel Like Factor 6) and associated molecular mechanisms on lipid metabolism in bovine adipocytes. In the current study, KLF6 gene expression was down regulated via siRNA (small interfering RNA) in bovine adipocytes in vitro. Subsequently, adipogenic cells were collected from the culture media after 9 days, and subjected to fluorescent imaging and RNA sequencing. After confirming that KLF6 was down regulated in bovine adipocytes by siRNA, differential gene expression analysis was used to characterize the infuence of KLF6 on gene expression profiles in bovine adipocyte...
Source: International Journal of Biological Macromolecules - December 10, 2021 Category: Biochemistry Authors: Sayed Haidar Abbas Raza Rajwali Khan Gong Cheng Feng Long Sun Bing Ahmed A Easa Nicola M Schreurs Sameer D Pant Wenzhen Zhang Anning Li Linsen Zan Source Type: research

Secreted PLA < sub > 2 < /sub > -III is a possible therapeutic target to treat neuropathic pain
Biochem Biophys Res Commun. 2021 Jul 5;568:167-173. doi: 10.1016/j.bbrc.2021.06.058. Online ahead of print.ABSTRACTLysophosphatidic acid (LPA) plays a critical role in developing and maintaining chronic pain in various animal models. Previous studies have reported that cytosolic and calcium-independent phospholipase A2 (PLA2) is involved in the LPA receptor-mediated amplification of LPA production in the spinal dorsal horn (SDH) after nerve injury, while the involvement of secreted PLA2 (sPLA2) remains unclear. The present study revealed that only sPLA2 -III among 11 species of PLA2 showed a significant upregulation of gen...
Source: Biochemical and Biophysical Research communications - July 8, 2021 Category: Biochemistry Authors: Keigo Tanaka Naoki Dozono Hiroyuki Neyama Jun Nagai Ryoko Tsukahara Kazuki Nagayasu Shuji Kaneko Hiroshi Ueda Source Type: research