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Transcription Factor MafB Suppresses Type I Interferon Production by CD14+ Monocytes in Patients With Chronic Hepatitis C
Transcription factor MafB regulates differentiation and activity of monocytes/macrophage, and is associated with the development of atherosclerosis and cancers. However, the role of MafB in modulation of CD14+ monocytes in chronic viral hepatitis was not fully elucidated. Thus, the aim of current study was to investigate the immunoregulatory function of MafB to type I interferon (IFN) secretion by CD14+ monocytes and its contribution to pathogenesis of chronic hepatitis C virus (HCV) infection. A total of twenty-nine chronic hepatitis C patients and twenty-one healthy individuals were enrolled. Serum IFN-α1 and IFN-β was...
Source: Frontiers in Microbiology - August 6, 2019 Category: Microbiology Source Type: research

SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis
Christine I. Alston1,2 and Richard D. Dix1,2* 1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research

The IL-6/STAT3 pathway upregulates microRNA-125b expression in hepatitis C virus infection.
Conclusions: This study elucidates a novel pathway for miR-125b in the pathogenesis of chronic HCV infection and suggests it as a possible target for treating HCV infection. PMID: 29541414 [PubMed]
Source: Oncotarget - March 16, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication.
Abstract Hepatitis C virus (HCV) is a positive-strand RNA virus responsible for chronic liver disease and hepatocellular carcinoma (HCC). Rac GTPase-activating protein 1 (RacGAP1) plays an important role during GTP hydrolysis to GDP in Rac1 and CDC42 protein and has been demonstrated to be upregulated in several cancers, including HCC. However, the molecular mechanism leading to the upregulation of RacGAP1 remains poorly understood. Here, we showed that RacGAP1 levels were enhanced in HCV cell-culture-derived (HCVcc) infection. More importantly, we illustrated that RacGAP1 interacts with the viral protein NS5B in ...
Source: Biochemical and Biophysical Research communications - October 8, 2014 Category: Biochemistry Authors: Wu MJ, Ke PY, Horng JT Tags: Biochem Biophys Res Commun Source Type: research

Abstract 3171: Overexpression of a cancer stem cell marker doublecortin-like kinase (DCLK1) leads to activation of inflammatory cascade during development of virus-induced hepatocellular carcinoma
Conclusions: DCLK1 overexpression appears to be intimately related to the activation of pro-inflammatory and MAPK signaling pathways during the development of virus-induced pre-neoplastic conditions and initiation of tumors in liver. Thus, targeting DCLK1 at early stage of liver diseases may prevent virus-induced cirrhosis and HCC. Citation Format: Naushad Ali, Parthasarathy Chandrakesan, Mark Huycke, Sanam Husain, Allison F. Gillaspy, Randal May, William L. Berry, Sripathi Sureban, Dongfeng Qu, Nathaniel Weygant, Michael S. Bronze, Danny N. Dhanasekaran, Courtney W. Houchen. Overexpression of a cancer stem cell marker dou...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Ali, N., Chandrakesan, P., Huycke, M., Husain, S., Gillaspy, A. F., May, R., Berry, W. L., Sureban, S., Qu, D., Weygant, N., Bronze, M. S., Dhanasekaran, D. N., Houchen, C. W. Tags: Carcinogenesis Source Type: research

High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential
In conclusion, high uMtCK expression in HCC may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator, and associated with highly malignant potential to suggest a poor prognosis. © 2013 UICC
Source: International Journal of Cancer - October 31, 2013 Category: Cancer & Oncology Authors: Baasanjav Uranbileg, Kenichiro Enooku, Yoko Soroida, Ryunosuke Ohkawa, Yotaro Kudo, Hayato Nakagawa, Ryosuke Tateishi, Haruhiko Yoshida, Seiko Shinzawa, Kyoji Moriya, Natsuko Ohtomo, Takako Nishikawa, Yukiko Inoue, Tomoaki Tomiya, Soichi Kojima, Tomokazu Tags: Early Detection and Diagnosis Source Type: research

High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly‐malignant potential
In conclusion, high uMtCK expression in HCC may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator, and associated with highly‐malignant potential to suggest a poor prognosis. © 2013 Wiley Periodicals, Inc.
Source: International Journal of Cancer - October 17, 2013 Category: Cancer & Oncology Authors: Baasanjav Uranbileg, Kenichiro Enooku, Yoko Soroida, Ryunosuke Ohkawa, Yotaro Kudo, Hayato Nakagawa, Ryosuke Tateishi, Haruhiko Yoshida, Seiko Shinzawa, Kyoji Moriya, Natsuko Ohtomo, Takako Nishikawa, Yukiko Inoue, Tomoaki Tomiya, Soichi Kojima, Tomokazu Tags: Early Detection and Diagnosis Source Type: research

Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome
Conclusions This study demonstrates specific genomic alterations in HCC/MS and points to CUL7 as a novel gene potentially involved in liver carcinogenesis associated with MS, the amplification of which might influence cell proliferation.
Source: Gut - April 30, 2013 Category: Gastroenterology Authors: Paradis, V., Albuquerque, M., Mebarki, M., Hernandez, L., Zalinski, S., Quentin, S., Belghiti, J., Soulier, J., Bedossa, P. Tags: Hepatic cancer Hepatology Source Type: research