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Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research

Persistent Escherichia coli infection in renal tubular cells enhances calcium oxalate crystal-cell adhesion by inducing ezrin translocation to apical membranes via Rho/ROCK pathway
In this study, Escherichia coli, the most common bacterium found in recurrent UTI was used to establish the in vitro model for persistent infection of renal epithelial cells. The promoting effects of persistent E. coli infection on kidney stone formation were validated by COM crystal-cell adhesion assay, followed by immunofluorescence study for changes in surface expression of the known COM crystal receptors. Among the five receptors examined, only ezrin had significantly increased level on the surface of persistently infected cells without change in its total level. Such translocation of ezrin to apical membranes was conf...
Source: Cellular and Molecular Life Sciences : CMLS - June 24, 2022 Category: Cytology Authors: Rattiyaporn Kanlaya Visith Thongboonkerd Source Type: research

LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF ‐κB/NLRP3 inflammasome pathway
ConclusionsThe expression of XIST was promoted by activated NF ‐κB pathway and, in turn, XIST generated a negative feedback loop to regulate NF‐κB/NLRP3 inflammasome pathway for mediating the process of inflammation.
Source: Cell Proliferation - October 25, 2018 Category: Cytology Authors: Mengru Ma, Yifei Pei, Xixi Wang, Jiaxin Feng, Yong Zhang, Ming ‐Qing Gao Tags: ORIGINAL ARTICLE Source Type: research

SM22 is required for the maintenance of actin-rich structures generated during bacterial infections.
Abstract The host actin cytoskeleton is utilized by an assortment of pathogenic bacteria to colonize and cause disease in their hosts. Two prominently studied actin-hijacking bacteria are enteropathogenic Escherichia coli (EPEC) and Listeria monocytogenes. EPEC form actin-rich pedestals atop its host cells to move across the intestinal epithelia, while Listeria monocytogenes generate branched actin networks arranged as actin clouds around the bacteria and as comet tails for propulsion within and amongst their host cells. Previous mass spectrometry analysis revealed that a member of the calponin family of actin-bun...
Source: Experimental Cell Research - May 17, 2018 Category: Cytology Authors: Chua MD, Hipolito KJ, Singerr OB, Solway J, Guttman JA Tags: Exp Cell Res Source Type: research

Double-stranded RNA induces cathelicidin expression in the intestinal epithelial cells through phosphatidylinositol 3-kinase-protein kinase C ζ-Sp1 pathway and ameliorates shigellosis in mice.
This study reports novel regulatory mechanisms of cathelicidin expression that may be targeted to treat gastro-intestinal infections. PMID: 28343946 [PubMed - as supplied by publisher]
Source: Cellular Signalling - March 24, 2017 Category: Cytology Authors: Ta A, Thakur BK, Dutta P, Sinha R, Koley H, Das S Tags: Cell Signal Source Type: research

G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK.
Abstract Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, invades and replicates within susceptible hosts by disturbing host antimicrobial mechanisms. Although G protein-coupled receptors (GPCRs) are involved in most physiological and pathological activities of mammalian cells, the roles of GPCRs in Mtb invasion into host cell remain elusive. Here, we report that GPR160 expression is elevated at both mRNA and protein level in macrophages in response to BCG infection. Both the PiggyBac (PB) transposon-mediated mutation of gpr160 gene in mouse primary macrophages and siRNA-mediated knockdown of...
Source: Cellular Signalling - May 30, 2016 Category: Cytology Authors: Yang H, Liu H, Chen H, Mo H, Chen J, Huang X, Zheng R, Liu Z, Feng Y, Liu F, Ge B Tags: Cell Signal Source Type: research

The ether lipid precursor hexadecylglycerol protects against Shiga toxins.
Abstract Shiga toxin-producing Escherichia coli bacteria cause hemorrhagic colitis and hemolytic uremic syndrome in humans. Currently, only supportive treatment is available for diagnosed patients. We show here that 24-h pretreatment with an ether lipid precursor, the alkylglycerol sn-1-O-hexadecylglycerol (HG), protects HEp-2 cells against Shiga toxin and Shiga toxin 2. Also the endothelial cell lines HMEC-1 and HBMEC are protected against Shiga toxins after HG pretreatment. In contrast, the corresponding acylglycerol, DL-α-palmitin, has no effect on Shiga toxicity. Although HG treatment provides a strong protec...
Source: Cellular and Molecular Life Sciences : CMLS - April 18, 2014 Category: Cytology Authors: Bergan J, Skotland T, Lingelem AB, Simm R, Spilsberg B, Lindbäck T, Sylvänne T, Simolin H, Ekroos K, Sandvig K Tags: Cell Mol Life Sci Source Type: research