Filtered By:
Source: Cancers

This page shows you your search results in order of date. This is page number 7.

Order by Relevance | Date

Total 223 results found since Jan 2013.

Cancers, Vol. 13, Pages 2066: Induction of Apoptosis, Inhibition of MCL-1, and VEGF-A Expression Are Associated with the Anti-Cancer Efficacy of Magnolol Combined with Regorafenib in Hepatocellular Carcinoma
wa Chen While regorafenib was approved for the treatment of advanced HCC in 2017, with a partial response and survival benefit; other combination agents to facilitate the efficacy of regorafenib still need to be explored. Magnolol is a potential natural anti-tumor compound for many types of cancers. Combination indexes calculated on the basis of both in vitro and in vivo models have indicated a synergistic effect of the combination of regorafenib and magnolol. The overexpression of the VEGF-A protein significantly diminished regorafenib’s inhibition of cell viability, while the transient knockdown of VEGF-A by siRNA ...
Source: Cancers - April 25, 2021 Category: Cancer & Oncology Authors: Cheng-Hsien Chen Fei-Ting Hsu Wei-Lung Chen Jiann-Hwa Chen Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2037: Functional Genomic Analyses of the 21q22.3 Locus Identifying Functional Variants and Candidate Gene YBEY for Breast Cancer Risk
iao-Ou Shu Qiuyin Cai We previously identified a locus at 21q22.3, tagged by the single nucleotide polymorphism (SNP) rs35418111, being associated with breast cancer risk at a genome-wide significance level; however, the underlying causal functional variants and gene(s) responsible for this association are unknown. We performed functional genomic analyses to identify potential functional variants and target genes that may mediate this association. Functional annotation for SNPs in high linkage disequilibrium (LD, r2 > 0.8) with rs35418111 in Asians showed evidence of promoter and/or enhancer activities, in...
Source: Cancers - April 23, 2021 Category: Cancer & Oncology Authors: Chris Shidal Xiang Shu Jie Wu Jifeng Wang Shuya Huang Jirong Long Joshua A. Bauer Jie Ping Xingyi Guo Wei Zheng Xiao-Ou Shu Qiuyin Cai Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2019: Oxaliplatin-Induced Senescence in Colorectal Cancer Cells Depends on p14ARF-Mediated Sustained p53 Activation
ristmann Senescence is an important consequence of cytostatic drug-based tumor therapy. Here we analyzed to which degree the anticancer drug oxaliplatin induces cell death, cell cycle arrest, and senescence in colorectal cancer (CRC) cells and elucidated the role of p53. Oxaliplatin treatment resulted in the G2-phase arrest in all CRC lines tested (HCT116p53+/+, HCT116p53−/−, LoVo, SW48 and SW480). Immunoblot analysis showed that within the p53-competent lines p53 and p21CIP1 are activated at early times upon oxaliplatin treatment. However, at later times, only LoVo cells showed sustained activation of the p53/p21C...
Source: Cancers - April 22, 2021 Category: Cancer & Oncology Authors: Maja T. Tomicic Franziska Kr ämer Alexandra Nguyen Christian Schwarzenbach Markus Christmann Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1998: CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51
In conclusion, we demonstrated for the first time that CD81 not only played a vital role in DNA repair through regulating Rad51 nuclear transport, but also might serve as a potential target of GBM radiotherapy.
Source: Cancers - April 21, 2021 Category: Cancer & Oncology Authors: Wang Zheng Qianping Chen Hongxia Liu Songling Hu Yuchuan Zhou Yang Bai Jianghong Zhang Yan Pan Chunlin Shao Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1885: KEAP1 Is Required for Artesunate Anticancer Activity in Non-Small-Cell Lung Cancer
ll M. Kolesar Artesunate is the most common treatment for malaria throughout the world. Artesunate has anticancer activity likely through the induction of reactive oxygen species, the same mechanism of action utilized in Plasmodium falciparum infections. Components of the kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway, which regulates cellular response to oxidative stress, are mutated in approximately 30% of non-small-cell lung cancers (NSCLC); therefore, we tested the hypothesis that KEAP1 is required for artesunate sensitivity in NSCLC. Dose response assays iden...
Source: Cancers - April 14, 2021 Category: Cancer & Oncology Authors: Kristen S. Hill Anthony McDowell J. Robert McCorkle Erin Schuler Sally R. Ellingson Rina Plattner Jill M. Kolesar Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1871: Inhibiting FAK –Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells
In conclusion, our data show that targeting FAK–paxillin interactions could be a potential therapeutic strategy to prevent metastasis formation, and molecules targeting this interface could be alternative to inhibitors of FAK kinase activity which display unexpected effects.
Source: Cancers - April 14, 2021 Category: Cancer & Oncology Authors: Antoine Mousson Marl ène Legrand Tania Steffan Romain Vauchelles Philippe Carl Jean-Pierre Gies Maxime Lehmann Guy Zuber Jan De Mey Denis Dujardin Emilie Sick Philippe Rond é Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1759: Zona Pellucida Protein 2 (ZP2) Is Expressed in Colon Cancer and Promotes Cell Proliferation
Conclusion: ZP2 shows an enhanced expression level in colon cancer tissue and, thus, can be used as a diagnostic tool, albeit in combination with other biomarkers. Its character as a membrane protein makes ZP2 even a potential target molecule for tumor therapy, especially as it positively affects colon cancer cell proliferation.
Source: Cancers - April 7, 2021 Category: Cancer & Oncology Authors: Dominik Kraus Alexander Glassmann Carsten Golletz Glen Kristiansen Jochen Winter Rainer Probstmeier Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1469: The Epithelial –Mesenchymal Transcription Factor SNAI1 Represses Transcription of the Tumor Suppressor miRNA let-7 in Cancer
In conclusion, the SNAI1/let-7 axis is an important component of stemness pathways in cancer cells, and this study provides a rationale for future work examining this axis as a potential target for cancer stem cell-specific therapies.
Source: Cancers - March 23, 2021 Category: Cancer & Oncology Authors: Hanmin Wang Evgeny Chirshev Nozomi Hojo Tise Suzuki Antonella Bertucci Michael Pierce Christopher Perry Ruining Wang Jeffrey Zink Carlotta A. Glackin Yevgeniya J. Ioffe Juli J. Unternaehrer Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1187: Molecular Signature of Small Cell Lung Cancer after Treatment Failure: The MCM Complex as Therapeutic Target
In this study, we identified a gene expression signature of SCLC after treatment failure using SCLC clinical specimens (GEO accession number: GSE162102). A total of 1,136 genes were significantly upregulated in SCLC tissues. These upregulated genes were subjected to KEGG pathway analysis, and “cell cycle”, “Fanconi anemia”, “alcoholism”, “systemic lupus erythematosus”, “oocyte meiosis”, “homologous recombination”, “DNA replication”, and “p53 signaling” were identified as the enriched pathways among the genes. We focused on the cell cycle pathway and investigated the clinical significance of ...
Source: Cancers - March 10, 2021 Category: Cancer & Oncology Authors: Shunsuke Misono Keiko Mizuno Takayuki Suetsugu Kengo Tanigawa Nijiro Nohata Akifumi Uchida Hiroki Sanada Reona Okada Shogo Moriya Hiromasa Inoue Naohiko Seki Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1216: Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis
Hideki Wanibuchi In the present study, potential molecular biomarkers of NASH hepatocarcinogenesis were investigated using the STAM mice NASH model, characterized by impaired insulin secretion and development of insulin resistance. In this model, 2-days-old C57BL/6N mice were subjected to a single subcutaneous (s.c.) injection of 200 μg streptozotocin (STZ) to induce diabetes mellitus (DM). Four weeks later, mice were administered high-fat diet (HFD) HFD-60 for 14 weeks (STAM group), or fed control diet (STZ group). Eighteen-week-old mice were euthanized to allow macroscopic, microscopic, histopathological, immun...
Source: Cancers - March 10, 2021 Category: Cancer & Oncology Authors: Anna Kakehashi Arpamas Chariyakornkul Shugo Suzuki Napaporn Khuanphram Kumiko Tatsumi Shotaro Yamano Masaki Fujioka Min Gi Rawiwan Wongpoomchai Hideki Wanibuchi Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1046: Targeting PVT1 Exon 9 Re-Expresses Claudin 4 Protein and Inhibits Migration by Claudin —Low Triple Negative Breast Cancer Cells
Cancers, Vol. 13, Pages 1046: Targeting PVT1 Exon 9 Re-Expresses Claudin 4 Protein and Inhibits Migration by Claudin—Low Triple Negative Breast Cancer Cells Cancers doi: 10.3390/cancers13051046 Authors: Fayola Levine Olorunseun O. Ogunwobi PVT1 is a long non-coding RNA transcribed from a gene located at the 8q24 chromosomal region that has been implicated in multiple cancers including breast cancer (BC). Amplification of the 8q24 chromosomal region is a common event in BC and is associated with poor clinical outcomes. Claudin–low (CL) triple negative breast cancer (TNBC) is a subtype of BC with a particularly...
Source: Cancers - March 2, 2021 Category: Cancer & Oncology Authors: Fayola Levine Olorunseun O. Ogunwobi Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1043: Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis
In this study, we demonstrate that siRNA-mediated USP22 depletion increases H2Bub1 levels in early mitosis and induces CIN phenotypes associated with mitotic chromatin compaction defects revealed by super-resolution microscopy. Moreover, USP22-knockout models exhibit continuously changing chromosome complements over time. These data identify mitotic removal of H2Bub1 as a critical determinant of chromatin compaction and faithful chromosome segregation. We further demonstrate that USP22 is a CIN gene, indicating that USP22 deletions, which are frequent in many tumor types, may drive genetic heterogeneity and contribute to cancer pathogenesis.
Source: Cancers - March 2, 2021 Category: Cancer & Oncology Authors: Lucile M. Jeusset Brent J. Guppy Zelda Lichtensztejn Darin McDonald Kirk J. McManus Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1021: TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation
We report that CD44 cleavage in A549 lung cancer cells and other cells is promoted by transforming growth factor-beta (TGFβ) in a manner that is dependent on ubiquitin ligase tumor necrosis factor receptor-associated factor 4 or 6 (TRAF4 or TRAF6, respectively). Stem-like A549 cells grown in spheres displayed increased TRAF4-dependent expression of CD44 variant isoforms, CD44 cleavage, and hyaluronan synthesis. Mechanistically, TRAF4 activated the small GTPase RAC1. CD44-dependent migration of A549 cells was inhibited by siRNA-mediated knockdown of TRAF4, which was rescued by the transfection of a constitutively active RA...
Source: Cancers - March 1, 2021 Category: Cancer & Oncology Authors: Constantinos Kolliopoulos Athanasios Chatzopoulos Spyros S. Skandalis Carl-Henrik Heldin Paraskevi Heldin Tags: Article Source Type: research

Cancers, Vol. 13, Pages 1010: EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells
a Viktorsson Ephrin (EFN)/ Erythropoietin-producing human hepatocellular receptors (Eph) signaling has earlier been reported to regulate non-small cell lung cancer (NSCLC) cell survival and cell death as well as invasion and migration. Here, the role of Ephrin type-A receptor 2 (EphA2) on the DNA damage response (DDR) signaling and ionizing radiation (IR) cellular effect was studied in NSCLC cells. Silencing of EphA2 resulted in IR sensitization, with increased activation of caspase-3, PARP-1 cleavage and reduced clonogenic survival. Profiling of EphA2 expression in a NSCLC cell line panel showed a correlation to an IR...
Source: Cancers - February 28, 2021 Category: Cancer & Oncology Authors: Vitaliy O. Kaminskyy Petra H ååg Metka Novak Ákos Végvári Vasiliki Arapi Rolf Lewensohn Kristina Viktorsson Tags: Article Source Type: research

Cancers, Vol. 13, Pages 944: Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma
wn Spencer J. Collis Brain tumours kill more children and adults under 40 than any other cancer, with approximately half of primary brain tumours being diagnosed as high-grade malignancies known as glioblastomas. Despite de-bulking surgery combined with chemo-/radiotherapy regimens, the mean survival for these patients is only around 15 months, with less than 10% surviving over 5 years. This dismal prognosis highlights the urgent need to develop novel agents to improve the treatment of these tumours. To address this need, we carried out a human kinome siRNA screen to identify potential drug targets that augment the e...
Source: Cancers - February 24, 2021 Category: Cancer & Oncology Authors: Natasha Carmell Ola Rominiyi Katie N. Myers Connor McGarrity-Cottrell Aurelie Vanderlinden Nikita Lad Eva Perroux-David Sherif F. El-Khamisy Malee Fernando Katherine G. Finegan Stephen Brown Spencer J. Collis Tags: Article Source Type: research