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Total 223 results found since Jan 2013.
Cancers, Vol. 14, Pages 1299: Role of GD3 Synthase ST8Sia I in Cancers
elannoy
GD3 synthase controls the biosynthesis of complex gangliosides, bearing two or more sialic acid residues. Disialylated gangliosides GD3 and GD2 are tumor-associated carbohydrate antigens (TACA) in neuro–ectoderm-derived cancers, and are directly involved in cell malignant properties, i.e., migration, invasion, stemness, and epithelial–mesenchymal transition. Since GD3 and GD2 levels are directly linked to GD3 synthase expression and activity, targeting GD3 synthase appears to be a promising strategy through which to interfere with ganglioside-associated malignant properties. We revie...
Source: Cancers - March 3, 2022 Category: Cancer & Oncology Authors: Angelina Kasprowicz Groux-Degroote Sophie Chann Lagadec Philippe Delannoy Tags: Review Source Type: research
Cancers, Vol. 14, Pages 1120: Estrogen Receptor-beta2 (ER & beta;2) & ndash;Mutant p53 & ndash;FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC)
Cancers, Vol. 14, Pages 1120: Estrogen Receptor-beta2 (ERβ2)–Mutant p53–FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC)
Cancers doi: 10.3390/cancers14051120
Authors:
Chetan C. Oturkar
Nishant Gandhi
Pramod Rao
Kevin H. Eng
Austin Miller
Prashant K. Singh
Emese Zsiros
Kunle O. Odunsi
Gokul M. Das
High grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of epithelial ovarian cancer. Prevalence (~96%) of mutant p53 is a hallmark of HGSOC. Estrogen receptor-beta (ER&am...
Source: Cancers - February 22, 2022 Category: Cancer & Oncology Authors: Chetan C. Oturkar Nishant Gandhi Pramod Rao Kevin H. Eng Austin Miller Prashant K. Singh Emese Zsiros Kunle O. Odunsi Gokul M. Das Tags: Article Source Type: research
Cancers, Vol. 14, Pages 1071: ADCK2 Knockdown Affects the Migration of Melanoma Cells via MYL6
Conclusion: ADCK2 affects melanoma cell motility, most probably via MYL6. Our results allow the conclusion that ADCK2 could act as a tumor suppressor in melanoma.
Source: Cancers - February 20, 2022 Category: Cancer & Oncology Authors: Marlene Vierthaler Qian Sun Yiman Wang Tamara Steinfass Juliane Poelchen Thomas Hielscher Daniel Novak Viktor Umansky Jochen Utikal Tags: Article Source Type: research
Cancers, Vol. 14, Pages 566: Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts
In conclusion, exosome-capturing Ab-conjugated siRNAs with branched Arg linkers can be effectively delivered into MM cells via uptake of exosomes by parental cells. This technology has the potential to lead to a breakthrough in drug delivery systems for hematologic cancers.
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Emi Soma Asako Yamayoshi Yuki Toda Yuji Mishima Shigekuni Hosogi Eishi Ashihara Tags: Article Source Type: research
Cancers, Vol. 14, Pages 531: CARD9 Forms an Alternative CBM Complex in Richter Syndrome
n Mellert
Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, mostly diffuse large B-cell lymphoma (DLBCL). Despite intensive therapy, patients with RS have an unfavorable clinical outcome. The detailed pathobiology of Richter transformation still needs to be elucidated. Here, we report high mRNA and protein levels of CARD9 in the RS cell line U-RT1. Co-immunoprecipitation revealed the assembly of a CBM complex using CARD9 instead of CARD11. CARD9 is known to be an activator of NF-кB signaling in myeloid cells. U-RT1 Western blot analys...
Source: Cancers - January 21, 2022 Category: Cancer & Oncology Authors: Julia Maier Andr é Lechel Ralf Marienfeld Thomas F. E. Barth Peter M öller Kevin Mellert Tags: Article Source Type: research
Cancers, Vol. 13, Pages 6261: The Estrogen Receptor & alpha; Signaling Pathway Controls Alternative Splicing in the Absence of Ligands in Breast Cancer Cells
Conclusion: Our data supports the role of apoERα in maintaining the luminal phenotype of BC cells by extensively regulating gene expression at the alternative splicing level.
Source: Cancers - December 13, 2021 Category: Cancer & Oncology Authors: Jamal Elhasnaoui Giulio Ferrero Valentina Miano Santina Cutrupi Michele De De Bortoli Tags: Article Source Type: research
Cancers, Vol. 13, Pages 6160: Microglial Cytokines Induce Invasiveness and Proliferation of Human Glioblastoma through Pyk2 and FAK Activation
In this study, 20 human glioblastoma specimens were evaluated with the use of RT-PCR and western blotting. A Pierson correlation test demonstrated a correlation (0.6–1.0) between the gene expression levels for platelet-derived growth factor β(PDGFβ), stromal-derived factor 1α (SDF-1α), IL-6, IL-8, and epidermal growth factor (EGF) in tumor-purified microglia and levels of p-Pyk2 (Y579/Y580) and p-FAK(Y925) in glioma cells. siRNA knockdown against Pyk2 or FAK in three primary glioblastoma cell lines, developed from the investigated specimens, in combination...
Source: Cancers - December 7, 2021 Category: Cancer & Oncology Authors: Rebeca E. Nu ñez Miguel Mayol del Valle Kyle Ortiz Luis Almodovar Lilia Kucheryavykh Tags: Article Source Type: research
Cancers, Vol. 13, Pages 5943: MEOX2 Transcription Factor Is Involved in Survival and Adhesion of Glioma Stem-Like Cells
In this study, we unraveled, for the first time, MEOX2 contribution to cell viability and proliferation through AKT/ERK pathway and its potential involvement in phenotype and adhesion properties of GSC.
Source: Cancers - November 25, 2021 Category: Cancer & Oncology Authors: Ga ëlle Tachon Konstantin Masliantsev Pierre Rivet Amandine Desette Serge Milin Elise Gueret Michel Wager Lucie Karayan-Tapon Pierre-Olivier Guichet Tags: Article Source Type: research
Cancers, Vol. 13, Pages 5863: IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma
T. Garrett
The use of BRAF and MEK inhibitors for patients with BRAF-mutant melanoma is limited as patients relapse on treatment as quickly as 6 months due to acquired resistance. We generated trametinib and dabrafenib resistant melanoma (TDR) cell lines to the MEK and BRAF inhibitors, respectively. TDR cells exhibited increased viability and maintenance of downstream p-ERK and p-Akt as compared to parental cells. Receptor tyrosine kinase arrays revealed an increase in p-IGF1R and p-IR in the drug resistant cells versus drug sensitive cells. RNA-sequencing analysis identified IGF1R and INSR upregulated in resistant ce...
Source: Cancers - November 22, 2021 Category: Cancer & Oncology Authors: Hima Patel Rosalin Mishra Nour Yacoub Samar Alanazi Mary Kate Kilroy Joan T. Garrett Tags: Article Source Type: research
Cancers, Vol. 13, Pages 5779: Kinome-Wide siRNA Screening Identifies DYRK1B as a Potential Therapeutic Target for Triple-Negative Breast Cancer Cells
Conclusions: our results suggest DYRK1B might be essential for promoting tumor progression and could be a theranostic target for TNBC. Silencing or inactivation of DYRK1B might be a potential targeted therapy for TNBC.
Source: Cancers - November 18, 2021 Category: Cancer & Oncology Authors: Chia-Che Chang Chien-Chih Chiu Pei-Feng Liu Chih-Hsuan Wu Yen-Chiang Tseng Cheng-Hsin Lee Chih-Wen Shu Tags: Article Source Type: research
Cancers, Vol. 13, Pages 5209: ARRDC4 and UBXN1: Novel Target Genes Correlated with Prostate Cancer Gleason Score
Byun
To investigate potential markers of the prostate cancer (PCa) Gleason score (GS), genetic arrays in 841 PCa patients were conducted followed by functional validation in PCa cell lines. A total of 841 PCa patients who received radical prostatectomy (RP) from November 2003 to July 2019 were enrolled. HumanExome BeadChip 12v1-1 (Illumina, Inc.; San Diego, CA, USA) exomic arrays were performed on RP tissue samples. Unconditional logistic regression was used to calculate odds ratios to generate estimates of the relative risk of pathologic GS (≥8); SNPs with the highest association were selected and validated using P...
Source: Cancers - October 17, 2021 Category: Cancer & Oncology Authors: Jong Jin Oh Jin-Nyoung Ho Seok-Soo Byun Tags: Article Source Type: research
Cancers, Vol. 13, Pages 4917: MiR-125b-5p Is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
In conclusion, miR-125b-5p suppressed ataxin-1 and consequently induced Snail-mediated EMT and stemness, leading to a poor prognosis in HCC patients.
Source: Cancers - September 30, 2021 Category: Cancer & Oncology Authors: Akihiro Hirao Yasushi Sato Hironori Tanaka Kensei Nishida Tetsu Tomonari Misato Hirata Masahiro Bando Yoshifumi Kida Takahiro Tanaka Tomoyuki Kawaguchi Hironori Wada Tatsuya Taniguchi Koichi Okamoto Hiroshi Miyamoto Naoki Muguruma Toshihito Tanahashi Tets Tags: Article Source Type: research
Cancers, Vol. 13, Pages 4425: Androgen Receptor-Mediated Nuclear Transport of NRDP1 in Prostate Cancer Cells Is Associated with Worse Patient Outcomes
a Ghosh
Ruth Vinall
To our knowledge, our group is the first to demonstrate that NRDP1 is located in the nucleus as well as the cytoplasm of CaP cells. Subcellular fractionation, immunohistochemistry, and immunofluorescence analysis combined with confocal microscopy were used to validate this finding. Subcellular fractionation followed by western blot analysis revealed a strong association between AR and NRDP1 localization when AR expression and/or cellular localization was manipulated via treatment with R1881, AR-specific siRNA, or enzalutamide. Transfection of LNCaP with various NRDP1 and AR constructs followed by ...
Source: Cancers - September 2, 2021 Category: Cancer & Oncology Authors: Thomas Steele Anhao Sam Shawna Evans Elizabeth Browning Sheryl Krig Katelyn Macias Adarsh Konda Salma Siddiqui Blythe Durbin-Johnson Paramita Ghosh Ruth Vinall Tags: Article Source Type: research
Cancers, Vol. 13, Pages 4293: ATP Inhibits Breast Cancer Migration and Bone Metastasis through Down-Regulation of CXCR4 and Purinergic Receptor P2Y11
Jean X. Jiang
ATP released by bone osteocytes is shown to activate purinergic signaling and inhibit the metastasis of breast cancer cells into the bone. However, the underlying molecular mechanism is not well understood. Here, we demonstrate the important roles of the CXCR4 and P2Y11 purinergic receptors in mediating the inhibitory effect of ATP on breast cancer cell migration and bone metastasis. Wound-healing and transwell migration assays showed that non-hydrolysable ATP analogue, ATPγS, inhibited migration of bone-tropic human breast cancer cells in a dose-dependent manner. BzATP, an agonist for P2X7 and an induce...
Source: Cancers - August 26, 2021 Category: Cancer & Oncology Authors: Xiaowen Liu Manuel A. Riquelme Yi Tian Dezhi Zhao Francisca M. Acosta Sumin Gu Jean X. Jiang Tags: Article Source Type: research
Cancers, Vol. 13, Pages 4123: Photodynamic Therapy Combined with Bcl-2/Bcl-xL Inhibition Increases the Noxa/Mcl-1 Ratio Independent of Usp9X and Synergistically Enhances Apoptosis in Glioblastoma
tsch
Georg Karpel-Massler
The purpose of this study was to assess in vitro whether the biological effects of 5-aminolevulinic acid (5-ALA)-based photodynamic therapy are enhanced by inhibition of the anti-apoptotic Bcl-2 family proteins Bcl-2 and Bcl-xL in different glioblastoma models. Pre-clinical testing of a microcontroller-based device emitting light of 405 nm wavelength in combination with exposure to 5-ALA (PDT) and the Bcl-2/Bcl-xL inhibitor ABT-263 (navitoclax) was performed in human established and primary cultured glioblastoma cells as well as glioma stem-like cells. We applied cell count analyses to asses...
Source: Cancers - August 17, 2021 Category: Cancer & Oncology Authors: Carolin Golla Mayas Bilal Annika Dwucet Nicolas Bader Jenson Anthonymuthu Tim Heiland Maximilian Pruss Mike-Andrew Westhoff Markus David Siegelin Felix Capanni Christian Rainer Wirtz Richard Eric Kast Marc-Eric Halatsch Georg Karpel-Massler Tags: Article Source Type: research
