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Source: Cancers

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Total 223 results found since Jan 2013.

Cancers, Vol. 13, Pages 4118: Genomic Mapping of Splicing-Related Genes Identify Amplifications in LSM1, CLNS1A, and ILF2 in Luminal Breast Cancer
rffy Vanesa García-Barberán Alberto Ocaña Alternative splicing is an essential biological process, which increases the diversity and complexity of the human transcriptome. In our study, 304 splicing pathway-related genes were evaluated in tumors from breast cancer patients (TCGA dataset). A high number of alterations were detected, including mutations and copy number alterations (CNAs), although mutations were less frequently present compared with CNAs. In the four molecular subtypes, 14 common splice genes showed high level amplification in >5% of patients. Certain genes were only amplified in specif...
Source: Cancers - August 16, 2021 Category: Cancer & Oncology Authors: Mar ía del Mar Noblejas-López Igor L ópez-Cade Jes ús Fuentes-Antrás Gonzalo Fern ández-Hinojal Ada Esteban-S ánchez Ar ánzazu Manzano Jos é Ángel García-Sáenz Pedro P érez-Segura Miguel De La Hoya Atanasio Pandiella Bal ázs Győrffy Vanesa Tags: Article Source Type: research

Cancers, Vol. 13, Pages 4106: The Association of Annexin A1 and Chemosensitivity to Osimertinib in Lung Cancer Cells
In this study, we focused on the association of ANXA1 and chemosensitivity with a third generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), Osimertinib, in lung cancer cells with EGFR mutations. The overexpression of ANXA1 was observed in the lung cancer cells studied. The downregulation of ANXA1 with small interference RNA (siRNA) decreased the growth of lung cancer cells. In lung cancer cells with EGFR mutations, the knockdown of ANXA1 increased the chemosensitivity to Osimertinib, and decreased the tumorigenesis, invasion and migration of lung cancer cells. Further study showed that the kno...
Source: Cancers - August 15, 2021 Category: Cancer & Oncology Authors: Min-Chun Chuang Jrhau Lung Yi-Chuan Chen Yu-Ching Lin Ya-Chin Li Ming-Szu Hung Tags: Article Source Type: research

Cancers, Vol. 13, Pages 3903: Identification of CNGB1 as a Predictor of Response to Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer
Rakesh Heer Cisplatin-based neoadjuvant chemotherapy (NAC) is recommended prior to radical cystectomy for muscle-invasive bladder cancer (MIBC) patients. Despite a 5–10% survival benefit, some patients do not respond and experience substantial toxicity and delay in surgery. To date, there are no clinically approved biomarkers predictive of response to NAC and their identification is urgently required for more precise delivery of care. To address this issue, a multi-methods analysis approach of machine learning and differential gene expression analysis was undertaken on a cohort of 30 MIBC cases highly selected for an...
Source: Cancers - August 2, 2021 Category: Cancer & Oncology Authors: Anastasia C. Hepburn Nicola Lazzarini Rajan Veeratterapillay Laura Wilson Jaume Bacardit Rakesh Heer Tags: Article Source Type: research

Cancers, Vol. 13, Pages 3727: Evaluating Targeted Therapies in Ovarian Cancer Metabolism: Novel Role for PCSK9 and Second Generation mTOR Inhibitors
la Ungureanu Background: Dysregulated lipid metabolism is emerging as a hallmark in several malignancies, including ovarian cancer (OC). Specifically, metastatic OC is highly dependent on lipid-rich omentum. We aimed to investigate the therapeutic value of targeting lipid metabolism in OC. For this purpose, we studied the role of PCSK9, a cholesterol-regulating enzyme, in OC cell survival and its downstream signaling. We also investigated the cytotoxic efficacy of a small library of metabolic (n = 11) and mTOR (n = 10) inhibitors using OC cell lines (n = 8) and ex vivo patient-derived cell cultures (PDCs, n = 5) to ide...
Source: Cancers - July 24, 2021 Category: Cancer & Oncology Authors: Dafne Jacome Sanz Juuli Raivola Hanna Karvonen Mariliina Arjama Harlan Barker Astrid Murum ägi Daniela Ungureanu Tags: Article Source Type: research

Cancers, Vol. 13, Pages 3612: Estrogen Receptor-Alpha and p53 Status as Regulators of AMPK and mTOR in Luminal Breast Cancer
. Das Luminal breast cancer (LBC) driven by dysregulated estrogen receptor-alpha (ERα) signaling accounts for 70% of the breast cancer cases diagnosed. Although endocrine therapy (ET) is effective against LBC, about one-third of these patients fail to respond to therapy owing to acquired or inherent resistance mechanisms. Aberrant signaling via ERα, oncogenes, growth factor receptors, and mutations in tumor suppressors such as p53 impinge on downstream regulators such as AMPK and mTOR. While both AMPK and mTOR have been reported to play important roles in determining sensitivity of LBC to ET, how the ERα-p53 crossta...
Source: Cancers - July 19, 2021 Category: Cancer & Oncology Authors: Nishant Gandhi Chetan C. Oturkar Gokul M. Das Tags: Article Source Type: research

Cancers, Vol. 13, Pages 3201: Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines
Conclusion: These novel findings demonstrated that STRAP plays a role in tumorigenesis and maintenance of neuroblastoma stemness.
Source: Cancers - June 26, 2021 Category: Cancer & Oncology Authors: Laura V Bownes Adele P Williams Raoud Marayati Colin H Quinn Sara C Hutchins Jerry E Stewart Trung Vu Juliet L Easlick Elizabeth Mroczek-Musulman David K Crossman Joshua C Anderson Christopher D Willey Pran K Datta Elizabeth A Beierle Tags: Article Source Type: research

Cancers, Vol. 13, Pages 3174: Establishment of a Novel In Vitro Model of Endometriosis with Oncogenic KRAS and PIK3CA Mutations for Understanding the Underlying Biology and Molecular Pathogenesis
Tohru Kiyono Satoru Kyo Endometriosis-harboring cancer-associated somatic mutations of PIK3CA and KRAS provides new opportunities for studying the multistep processes responsible for the functional and molecular changes in this disease. We aimed to establish a novel in vitro endometriosis model to clarify the functional behavior and molecular pathogenesis of this disorder. Immortalized HMOsisEC10 human ovarian endometriotic epithelial cell line was used in which KRAS and PIK3CA mutations were introduced. Migration, invasion, proliferation, and microarray analyses were performed using KRAS and PIK3CA mutant cell lines...
Source: Cancers - June 25, 2021 Category: Cancer & Oncology Authors: Mohammad Mahmud Hossain Kentaro Nakayama Kamrunnahar Shanta Sultana Razia Masako Ishikawa Tomoka Ishibashi Hitomi Yamashita Seiya Sato Kouji Iida Kosuke Kanno Noriyoshi Ishikawa Tohru Kiyono Satoru Kyo Tags: Article Source Type: research

Cancers, Vol. 13, Pages 3165: The Identification of RNA-Binding Proteins Functionally Associated with Tumor Progression in Gastrointestinal Cancer
a Mikihiro Fujiya Previous investigations have indicated that RNA-binding proteins (RBPs) are key molecules for the development of organs, differentiation, cell growth and apoptosis in cancer cells as well as normal cells. A bioinformatics analysis based on the mRNA expression and a somatic mutational database revealed the association between aberrant expression/mutations of RBPs and cancer progression. However, this method failed to detect functional alterations in RBPs without changes in the expression, thus leading to false negatives. To identify major tumor-associated RBPs, we constructed an siRNA library based o...
Source: Cancers - June 24, 2021 Category: Cancer & Oncology Authors: Hiroaki Konishi Shin Kashima Takuma Goto Katsuyoshi Ando Aki Sakatani Hiroki Tanaka Nobuhiro Ueno Kentaro Moriichi Toshikatsu Okumura Mikihiro Fujiya Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2986: Nucleolin Targeting by N6L Inhibits Wnt/ β-Catenin Pathway Activation in Pancreatic Ductal Adenocarcinoma
In conclusion, in this study, we identified β-catenin as a new nucleolin interactor and suggest that the Wnt/β-catenin pathway could be a new target of the nucleolin antagonist N6L in PDAC.
Source: Cancers - June 15, 2021 Category: Cancer & Oncology Authors: Fabio Raineri Sandrine Bourgoin-Voillard M élissande Cossutta Damien Habert Matteo Ponzo Claire Houppe Beno ît Vallée Michele Boniotto Mounira Chalabi-Dchar Philippe Bouvet Anne Couvelard Jerome Cros Anais Debesset Jos é L. Cohen Jos é Courty Ilaria Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2745: CC Chemokine Ligand 7 Derived from Cancer-Stimulated Macrophages Promotes Ovarian Cancer Cell Invasion
We examined the effect of these macrophages on human ovarian cancer cell invasion and found that conditioned medium of macrophages stimulated by ovarian cancer cells (OC-MQs) significantly increased cell invasion. CC chemokine ligand 7 (CCL7) expression and production were significantly higher in OC-MQs than in the control macrophages. Peritoneal macrophages from patients with ovarian cancer showed higher CCL7 expression levels than those from healthy controls. Inhibition of CCL7 using siRNA and neutralizing antibodies reduced the OC-MQ-CM-induced ovarian cancer cell invasion. CC chemokine receptor 3 (CCR3) was highly expr...
Source: Cancers - June 1, 2021 Category: Cancer & Oncology Authors: Miran Jeong Yi-Yue Wang Ju-Yeon Choi Myong-Cheol Lim Jung-Hye Choi Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2397: Therapeutic Silencing of BCL-2 Using NK Cell-Derived Exosomes as a Novel Therapeutic Approach in Breast Cancer
e Märklin Overexpression of the anti-apoptotic protein BCL-2 is frequently observed in multiple malignancies, including about 85% of patients with estrogen receptor positive (ER+) breast cancer. Besides being studied as a prognostic marker, BCL-2 is investigated as a therapeutic target in ER+ breast cancer. Here, we introduce a new exosome-based strategy to target BCL-2 using genetically modified natural killer (NK) cells. The NK cell line NK92MI was lentivirally transduced to express and load BCL-2 siRNAs (siBCL-2) into exosomes (NKExos) and then evaluated for its potential to treat ER+ breast cancer. Transfected NK9...
Source: Cancers - May 15, 2021 Category: Cancer & Oncology Authors: K übra Kaban Clemens Hinterleitner Yanjun Zhou Emine Salva Ayse G ülten Kantarci Helmut R. Salih Melanie M ärklin Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2395: Orai1 Channel Regulates Human-Activated Pancreatic Stellate Cell Proliferation and TGF β1 Secretion through the AKT Signaling Pathway
Cancers, Vol. 13, Pages 2395: Orai1 Channel Regulates Human-Activated Pancreatic Stellate Cell Proliferation and TGFβ1 Secretion through the AKT Signaling Pathway Cancers doi: 10.3390/cancers13102395 Authors: Silviya Radoslavova Antoine Folcher Thibaut Lefebvre Kateryna Kondratska Stéphanie Guénin Isabelle Dhennin-Duthille Mathieu Gautier Natalia Prevarskaya Halima Ouadid-Ahidouch Activated pancreatic stellate cells (aPSCs), the crucial mediator of pancreatic desmoplasia, are characterized, among others, by high proliferative potential and abundant transforming growth factor β1 (TGFβ1) secretio...
Source: Cancers - May 15, 2021 Category: Cancer & Oncology Authors: Silviya Radoslavova Antoine Folcher Thibaut Lefebvre Kateryna Kondratska St éphanie Guénin Isabelle Dhennin-Duthille Mathieu Gautier Natalia Prevarskaya Halima Ouadid-Ahidouch Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2318: Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes
im Martin Götte Triple-negative breast cancer (TNBC) is characterized by increased angiogenesis, metastasis, and poor survival. Dysregulation of the cell surface heparan sulfate proteoglycan and signaling co-receptor Syndecan-1 is linked to poor prognosis. To study its role in angiogenesis, we silenced Syndecan-1 in TNBC cell lines using a 3D human umbilical vein endothelial cell (HUVEC) co-culture system. Syndecan-1 siRNA depletion in SUM-149, MDA-MB-468, and MDA-MB-231 cells decreased HUVEC tubule network formation. Angiogenesis array revealed reduced VEGF-A and tissue factor (TF) in the Syndecan-1-silenced secret...
Source: Cancers - May 12, 2021 Category: Cancer & Oncology Authors: Eyyad Nassar Nourhan Hassan Eslam A. El-Ghonaimy Hebatallah Hassan Mahmoud Salah Abdullah Theresa V. Rottke Ludwig Kiesel Burkhard Greve Sherif Abdelaziz Ibrahim Martin G ötte Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2250: IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer
Barak Rotblat Moshe Elkabets Over 50% of human papilloma positive head-and-neck cancer (HNCHPV+) patients harbor genomic-alterations in PIK3CA, leading to hyperactivation of the phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) pathway. Nevertheless, despite PI3K pathway activation in HNCHPV+ tumors, the anti-tumor activities of PI3K pathway inhibitors are moderate, mostly due to the emergence of resistance. Thus, for potent and long-term tumor management, drugs blocking resistance mechanisms should be combined with PI3K inhibitors. Here, we delineate the molecular mechanisms of the acquisition of resistance to...
Source: Cancers - May 7, 2021 Category: Cancer & Oncology Authors: Mai Badarni Manu Prasad Artemiy Golden Baisali Bhattacharya Liron Levin Ksenia M. Yegodayev Orr Dimitstein Ben-Zion Joshua Limor Cohen Ekaterina Khrameeva Dexin Kong Angel Porgador Alex Braiman Jennifer R. Grandis Barak Rotblat Moshe Elkabets Tags: Article Source Type: research

Cancers, Vol. 13, Pages 2105: Increased Extracellular Adenosine in Radiotherapy-Resistant Breast Cancer Cells Enhances Tumor Progression through A2AR-Akt-b-Catenin Signaling
ye Jung Kim Recently, we found that the expressions of adenosine (ADO) receptors A2AR and A2BR and the ectonucleotidase CD73 which is needed for the conversion of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) and the extracellular ADO level are increased in TNBC MDA-MB-231 cells and RT-R-MDA-MB-231 cells compared to normal cells or non-TNBC cells. The expression of A2AR, but not A2BR, is significantly upregulated in breast cancer tissues, especially TNBC tissues, compared to normal epithelial tissues. Therefore, we further investigated the role of ADO-activated A2AR and its signaling pathway in the progre...
Source: Cancers - April 27, 2021 Category: Cancer & Oncology Authors: Hana Jin Jong Sil Lee Dong Chul Kim Young Shin Ko Gyeong Won Lee Hye Jung Kim Tags: Article Source Type: research