Filtered By:
Source: Cancers

This page shows you your search results in order of date. This is page number 14.

Order by Relevance | Date

Total 223 results found since Jan 2013.

Cancers, Vol. 11, Pages 786: Collagen 1A1 (COL1A1) Is a Reliable Biomarker and Putative Therapeutic Target for Hepatocellular Carcinogenesis and Metastasis
In this study, using bioinformatics analysis of publicly-available HCC microarray data from Gene Expression Omnibus (GEO) and RNAseq data from The Cancer Genome Atlas (TCGA) database, we determined that COL1A1 is significantly upregulated in HCC tumor tissues in comparison to normal tissues. Our analysis also revealed that COL1A1 confers survival advantage and enhanced oncogenicity on HCC cells. Interestingly, the siRNA-mediated silencing of COL1A1 expression (siCOLIA1) suppressed HCC cells clonogenicity, motility, invasiveness and tumorsphere formation. Concomitantly, siCOL1A1 abrogated Slug-dependent epithelial-to-mesenc...
Source: Cancers - June 6, 2019 Category: Cancer & Oncology Authors: Hon-Ping Ma Hang-Lung Chang Oluwaseun Adebayo Bamodu Vijesh Kumar Yadav Ting-Yi Huang Alexander T. H. Wu Chi-Tai Yeh Shin-Han Tsai Wei-Hwa Lee Tags: Article Source Type: research

Cancers, Vol. 11, Pages 701: Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression
In conclusion, this study demonstrates a role for TG2 in the stromal response to invading tumour, leading to tissue stiffening and poor outcome in patients.
Source: Cancers - May 20, 2019 Category: Cancer & Oncology Authors: Robin Delaine-Smith Nicola Wright Chris Hanley Rebecca Hanwell Rahul Bhome Marc Bullock Cole Drifka Kevin Eliceiri Gareth Thomas Martin Knight Alex Mirnezami Nicholas Peake Tags: Article Source Type: research

Cancers, Vol. 11, Pages 632: Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer
howdhury Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development would give a promising therapeutics strategy in combating the disease. Genetic manipulations through siRNAs targeting the complementary sequence of the oncogenic mRNA in breast cancer is one of the promising approaches that can be harnessed to develop more efficient treatments for breast cancer. In this review, we hi...
Source: Cancers - May 5, 2019 Category: Cancer & Oncology Authors: Kamaruzman Aziz Poh Chowdhury Tags: Review Source Type: research

Cancers, Vol. 11, Pages 604: High Mannose Binding Lectin (PFL) from Pseudomonas fluorescens Down-Regulates Cancer-Associated Integrins and Immune Checkpoint Ligand B7-H4
Toshio Seyama Pseudomonas fluorescens lectin (PFL), which belongs to the high mannose (HM)-binding OAAH (Oscillatoria agardhii agglutinin homologue) lectin family, induces cancer cell death. However, the detailed mechanisms underlying this process have not yet been elucidated. We found that PFL decreased various integrins as well as EGFR in cancer cells by promoting internalization and autophagic degradation of these molecules, subsequently inducing caspase-8 dependent cell apoptosis. As revealed by an ex vivo angiogenesis assay using the rat aortic model, PFL inhibited neovascularization in a dose-dependent manner, wh...
Source: Cancers - April 29, 2019 Category: Cancer & Oncology Authors: Yuichiro Sato Kiminori Matsubara Takanori Kubo Hirobumi Sunayama Yuta Hatori Kinjiro Morimoto Toshio Seyama Tags: Article Source Type: research

Cancers, Vol. 11, Pages 587: Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival
In this study, we investigated the potential of integrin α10β1 as a therapeutic target in GBMs. Expression levels and the role of integrin α10β1 were studied in patient-derived GBM tissues and cell lines. The effect of an antibody–drug conjugate (ADC), an integrin α10 antibody conjugated to saporin, on GBM cells and in a xenograft mouse model was studied. We found that integrin α10β1 was strongly expressed in both GBM tissues and cells, whereas morphologically unaffected brain tissues showed only minor expression. P...
Source: Cancers - April 24, 2019 Category: Cancer & Oncology Authors: Matilda Munksgaard Thor én Katarzyna Chmielarska Masoumi Cecilia Krona Xiaoli Huang Soumi Kundu Linn éa Schmidt Karin Forsberg-Nilsson Marcus Floyd Keep Elisabet Englund Sven Nelander Bo Holmqvist Evy Lundgren- Åkerlund Tags: Article Source Type: research

Cancers, Vol. 11, Pages 562: Dual Targeting of Y-Box Binding Protein-1 and Akt Inhibits Proliferation and Enhances the Chemosensitivity of Colorectal Cancer Cells
In this study, the effects of oncogenic mutated KRAS(G12V) and KRAS(G13D) on YB-1 phosphorylation were investigated in CRC cells. The effects of the inhibition of p90 ribosomal S6 kinase (RSK) on YB-1 phosphorylation, cell proliferation and survival were tested with and without treatment with 5-fluorouracil using pharmacological inhibitors and siRNA. YB-1 phosphorylation status and subcellular distribution in CRC patient tissues were determined by immunofluorescence staining and confocal microscopy. Endogenous expression of mutated KRAS(G13D) and conditional expression of KRAS(G12V) significantly stimulated YB-1 phosphoryl...
Source: Cancers - April 18, 2019 Category: Cancer & Oncology Authors: Maier Attenberger Tiwari Lettau Rebholz Fehrenbacher Schaller Gani Toulany Tags: Article Source Type: research

Cancers, Vol. 11, Pages 545: Identification of KIF11 As a Novel Target in Meningioma
Unterberg Abdollahi Herold-Mende Kinesins play an important role in many physiological functions including intracellular vesicle transport and mitosis. The emerging role of kinesins in different cancers led us to investigate the expression and functional role of kinesins in meningioma. Therefore, we re-analyzed our previous microarray dataset of benign, atypical, and anaplastic meningiomas (n = 62) and got evidence for differential expression of five kinesins (KIFC1, KIF4A, KIF11, KIF14 and KIF20A). Further validation in an extended study sample (n = 208) revealed a significant upregulation of these genes in W...
Source: Cancers - April 14, 2019 Category: Cancer & Oncology Authors: Jungwirth Yu Moustafa Rapp Warta Jungk Sahm Dettling Zweckberger Lamszus Senft Loehr Ke ßler Ketter Westphal Debus von Deimling Simon Unterberg Abdollahi Herold-Mende Tags: Article Source Type: research

Cancers, Vol. 11, Pages 502: A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell Characteristics in Ovarian Cancer
Daniela Matei A small of population of slow cycling and chemo-resistant cells referred to as cancer stem cells (CSC) have been implicated in cancer recurrence. There is emerging interest in developing targeted therapeutics to eradicate CSCs. Aldehyde-dehydrogenase (ALDH) activity was shown to be a functional marker of CSCs in ovarian cancer (OC). ALDH activity is increased in cells grown as spheres versus monolayer cultures under differentiating conditions and in OC cells after treatment with platinum. Here, we describe the activity of CM37, a newly identified small molecule with inhibitory activity against ALDH1A1, in...
Source: Cancers - April 7, 2019 Category: Cancer & Oncology Authors: Nkechiyere G. Nwani Salvatore Condello Yinu Wang Wendy M. Swetzig Emma Barber Thomas Hurley Daniela Matei Tags: Article Source Type: research

Cancers, Vol. 11, Pages 466: Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration
Lawler We previously showed lithium chloride (LiCl) and other inhibitors of glycogen synthase kinase-3 (GSK-3) including 6-bromo-indirubin-3-oxime (BIO), can block glioblastoma (GBM) cell migration. To investigate the mechanisms involved we used two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry to identify proteins altered after treatment of U251 GBM cells with 20 mM LiCl. Downregulation of the intermediate filament protein vimentin was the most significant change identified. Analysis of patient tumor samples revealed that vimentin is expressed abundantly in GBM, and is prognostic espec...
Source: Cancers - April 2, 2019 Category: Cancer & Oncology Authors: Michal O. Nowicki Josie L. Hayes E. Antonio Chiocca Sean E. Lawler Tags: Article Source Type: research

Cancers, Vol. 11, Pages 446: Ion Channel Expression in Human Melanoma Samples: In Silico Identification and Experimental Validation of Molecular Targets
In conclusion, the present study identified five ion channels that can potentially serve as sensitive and specific markers in human melanoma specimens and demonstrates that the antifungal drug miconazole, known to target one of the five identified ion channels, exerts strong and specific anti-melanoma effects in vitro.
Source: Cancers - March 28, 2019 Category: Cancer & Oncology Authors: Daniela D ’Arcangelo Francesca Scatozza Claudia Giampietri Paolo Marchetti Francesco Facchiano Antonio Facchiano Tags: Article Source Type: research

Cancers, Vol. 11, Pages 442: Targeted siRNA Nanoparticles for Mammary Carcinoma Therapy
Gershon Golomb Non-viral, polymeric-based, siRNA nanoparticles (NPs) have been proposed as promising gene delivery systems. Encapsulating siRNA in targeted NPs could confer improved biological stability, extended half-life, enhanced permeability, effective tumor accumulation, and therapy. In this work, a peptide derived from apolipoprotein B100 (ApoB-P), the protein moiety of low-density lipoprotein, was used to target siRNA-loaded PEGylated NPs to the extracellular matrix/proteoglycans (ECM/PGs) of a mammary carcinoma tumor. siRNA against osteopontin (siOPN), a protein involved in breast cancer development and progre...
Source: Cancers - March 28, 2019 Category: Cancer & Oncology Authors: Meital Ben-David-Naim Arie Dagan Etty Grad Gil Aizik Mirjam M. Nordling-David Alisa Morss Clyne Zvi Granot Gershon Golomb Tags: Article Source Type: research

Cancers, Vol. 11, Pages 430: Store-Operated Calcium Entry Contributes to Cisplatin-Induced Cell Death in Non-Small Cell Lung Carcinoma
In this study, we showed that siRNA-mediated depletion of stromal interaction molecule 1 (STIM1) and transient receptor potential channel 1 (TRPC1), two players of the store-operated calcium entry, dramatically reduced CDDP cytotoxicity in NSCLC cells. This was associated with an inhibition of the DNA damage response (DDR) triggered by CDDP. Moreover, STIM1 depletion also reduced CDDP-dependent oxidative stress. In parallel, SOCE activation induced Ca2+ entry into the mitochondria, a major source of reactive oxygen species (ROS) within the cell. This effect was highly decreased in STIM1-depleted cells. We then conclude tha...
Source: Cancers - March 25, 2019 Category: Cancer & Oncology Authors: Roberta Gualdani Marie de Clippele Ikram Ratbi Philippe Gailly Nicolas Tajeddine Tags: Article Source Type: research

Cancers, Vol. 11, Pages 406: Alpha6-Integrin Regulates FGFR1 Expression through the ZEB1/YAP1 Transcription Complex in Glioblastoma Stem Cells Resulting in Enhanced Proliferation and Stemness
Catherine SEVA Glioblastoma (GBM) is the most lethal primary brain tumor in adults and is known to be particularly aggressive and resistant to anti-cancer therapies, mainly due to the presence of GBM stem cells (GBMSC). By in vitro approaches supported by analysis from patients’ databases, we determined how α6-integrin and Fibroblast Growth Factor Receptor 1 (FGFR1) work in concert to regulate proliferation and stemness of GBMSC. We showed that α6-integrin regulates the expression of FGFR1 and its target gene Fokhead Box M1 (FOXM1) via the ZEB1/YAP1 transcription complex. Thes...
Source: Cancers - March 21, 2019 Category: Cancer & Oncology Authors: Aline KOWALSKI-CHAUVEL Valerie GOUAZE-ANDERSSON Laurent BARICAULT Elodie MARTIN Caroline DELMAS Christine TOULAS Elizabeth COHEN-JONATHAN-MOYAL Catherine SEVA Tags: Article Source Type: research

Cancers, Vol. 11, Pages 386: Radiosensitivity of Cancer Cells Is Regulated by Translationally Controlled Tumor Protein
This study reveals that the regulation of radiosensitivity of cancer cells is yet another function of TCTP. The relationship between endogenous TCTP levels and sensitivity to radiation was examined in breast cancer cell lines (T47D, MDA-MB-231, and MCF7) and lung cancer cells lines (A549, H1299, and H460). Cancer cells with high expression levels of TCTP were more resistant to radiation. TCTP overexpression inhibited radiation-induced cell death, while silencing TCTP led to an increase in radiosensitivity. DNA damage in the irradiated TCTP-silenced A549 cells was greater than in irradiated control shRNA-transfected A549 ce...
Source: Cancers - March 18, 2019 Category: Cancer & Oncology Authors: Jiwon Jung Ji-Sun Lee Yun-Sil Lee Kyunglim Lee Tags: Article Source Type: research

Cancers, Vol. 11, Pages 333: Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model
r Donat Kögel Glioblastoma (GBM), WHO grade IV, is the most aggressive primary brain tumor in adults. The median survival time using standard therapy is only 12–15 months with a 5-year survival rate of around 5%. Thus, new and effective treatment modalities are of significant importance. Signal transducer and activator of transcription 3 (Stat3) is a key signaling protein driving major hallmarks of cancer and represents a promising target for the development of targeted glioblastoma therapies. Here we present data showing that the therapeutic application of siRNAs, formulated in nanoscale lipopolyplexe...
Source: Cancers - March 7, 2019 Category: Cancer & Oncology Authors: Benedikt Linder Ulrike Weirauch Alexander Ewe Anja Uhmann Volker Seifert Michel Mittelbronn Patrick N. Harter Achim Aigner Donat K ögel Tags: Article Source Type: research