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Source: European Respiratory Journal
Condition: Asthma
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Total 29 results found since Jan 2013.
MiR-125b-5p up-regulation in asthma and COPD overlap patients mediates oxidative stress and apoptosis via targeting IL6R/NLRC5/TRIAP1
Conclusions: MiR-125b-5p is up-regulated in ACO patients, and may cause oxidative stress and cell apoptosis through targeting IL6R, NLRC5, TRIAP1 genes.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Chang, Y., Lee, C., Chen, Y. Tags: 03.01 - Molecular pathology and functional genomics Source Type: research
Identify Bcl3 as a novel biomarker shared between severe asthma and lung cancer using next-generation RNA sequencing from archival FFPE tissue biopsies
Conclusion: Our findings indicate a Bcl3 a novel putative biomarker in pathogeneses of both severe asthma and lung cancer.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Salameh, L., Manasa Bhamidimarri, P., Elemam, N., Ali, N., Dairi, Y., Alsharhan, M., Tirmazy, S. H., Hamid, Q., Mahboub, B., Al Heialy, S., Hamoudi, R. Tags: 03.03 - Mechanisms of lung injury and repair Source Type: research
Screening and verification of differentially expressed genes for airway remodeling in asthma
Conclusion: The expression of CTSK may related to the airway remodeling of asthma by up-regulating the TGF-β1 expression in BECs.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Qin, L., Liu, C., Wu, M., Yao, Y. Tags: 05.03 - Allergy and immunology Source Type: research
Exogenous HSP70 regulates the expression of glucocorticoid receptor in a cell type-specific manner
Conclusion: Exogenous HSP70 increases the expression of GR in EC in a cell type-specific manner. Such effect suggests that EC have an increased sensitivity towards steroids. As EC require cortisol for their recovery from stress, for proliferation, and for differentiation, these data could explain the fast recovery of the epithelium after thermoplasty, as well as the clinically observed reduced need of steroids after thermoplasty.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Zhou, L., Fang, L., Tamm, M., Roth, M., Stolz, D. Tags: 05.01 - Airway pharmacology and treatment Source Type: research
Late Breaking Abstract - DCLK1 mediates thrombin-induced IL-8/CXCL8 expression in lung epithelial cells
Airway neutrophilia has been known correlated with asthma severity. Thrombin plays a crucial role in asthma. Thrombin can induce IL-8/CXCL8 expression, a potent chemoattractant for neutrophils, in lung epithelial cells. Doublecortin-like kinase 1 (DCLK1) is a protein kinase that has been identified as a tumor stem cell marker in colon and pancreatic cancer. Here we investigated the role of DCLK1 in thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells. Thrombin-induced IL-8/CXCL8 release was attenuated by DCLK1 siRNA or LRKK2-IN-1 (DCLK1 inhibitor) in BEAS-2B and A549 cells. Moreover, thrombin-induced IL-8/...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Yuliani, F. S., Chen, J.-Y., Cheng, W.-H., Wen, H.-C., Chen, B.-C., Lin, C.-H. Tags: Allergy and immunology Source Type: research
LSC - 2021 - COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding
Conclusion: Our data suggests an epigenetic modification at cg11797365 interrupts ZNF263 binding which may contribute to the COL4A3 expression deficit in asthmatic airways.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Sai Sneha Priya, N., Joseph Vermeulen, C., Pech, M., Faiz, A., George G. Oliver, B., Van Den Berge, M., Kay Burgess, J., Kopp, M., Weckmann, M. Tags: Occupational and environmental health Source Type: research
UPF1 and STAU1 modulate rhinovirus pathophysiology contributing to impaired antiviral immunity in asthma
Conclusions: Decreased UPF1 levels in asthma BECs underlie their impaired antiviral immunity. We demonstrate for the first time the interplay between two novel factors, UPF1 and STAU1, in RV pathophysiology and induced exacerbations.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Martinez-Nunez, R. T., Richardson, A., Ponde, N., Bagley, D., Ortiz-Zapater, E., Rynne, J., Howarth, P., Rosenblatt, J., Edwards, M. Tags: Airway cell biology and immunopathology Source Type: research
Thrombin induces stomatin-like protein 2 (STOML2) expression and IL-8/CXCL8 release by ROCK, JNK, and PEA3 pathways in human lung epithelial cells
In this study, we investigate whether Rho kinase (ROCK), JNK, and PEA3 participate in thrombin-induced STOML2 expression and IL-8/CXCL8 release in human lung epithelial cells. We found that thrombin induced increase in STOML2, but not prohibitin, expression in a time-dependent manner. Thrombin also induces STOML2-luciferase activity. Thrombin-induced STOML2 expression and IL-8/CXCL8 release were reduced by PEA3 siRNA. We also found that transfection of A549 cells with PEA3 siRNA reduced PEA3 protein expression. In addition, thrombin induced increase in PEA3 Ser phosphorylation and PEA3 translocation from the cytosol to the...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Chen, B.-C., Lin, C.-H. Tags: Airway pharmacology and treatment Source Type: research
Cbx4 Regulates RNA Binding Protein MEX-3B To Thymic stromal lymphopoietin Expression Sumoylation In Epithelium Of HDM-induced Allergic Inflammation
Conclusion: CBX4/MEX-3B/TSLP axis involved in TSLP-mediated airway inflammation,suggesting that targeting SUMO E3 ligase activity of CBX4 would be a novel target for the treatment of asthma.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: shixiu, l., Changhui, Y., Zicong, Z., Zili, Z., Jieyi, L., Shaoxi, C. Tags: Allergy and immunology Source Type: research
Human airway trypsin-like protease stimulates protease activated receptors and interactions of these receptors
Conclusions: These results indicate that HAT may attack and activate PAR1, PAR2 and PAR3 in HBECs. These PARs, particularly PAR2 and PAR3, are intimately associated with IL-8 synthesis in HBECs, by mutual interrelations.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Miki, M., Yasuoka, S., Tsutsumi, R., Takeuchi, Y., Miki, K., Kitada, S. Tags: Airway cell biology and immunopathology Source Type: research
LSC - 2019 - RNA degradation is a deficient antiviral mechanism in the asthmatic airway epithelium
Conclusions: Our data suggest that decreased UPF1 levels in asthma BECs contribute to impaired antiviral immunity and RV-induced exacerbations in asthma.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Wong, T., Rynne, J., Howarth, P. H., Edwards, M. R., Martinez-Nunez, R. T. Tags: Respiratory infections Source Type: research
Increased CTGF expression of circulating fibrocytes in asthmatic patients with severe OSA - the role of HIF-1a and HDAC7
Conclusion: Severe OSA related hypoxia increases CTGF expression in circulating fibrocytes via activation of HIF-1α that requires HDAC7 nuclear co-transprotation. HDAC7 may serve a therapeutic target for airway remodeling in asthmatics with severe OSA.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wang, T.-Y., Lo, Y.-L., Wang, C.-H., Kuo, H.-P. Tags: Airway Cell Biology and Immunopathology Source Type: research
Club Cell Protein-16 modifies airway inflammation in asthma and is associated with significant clinical asthma outcomes
Conclusion: Lack of CC16 results in enhanced T2 inflammatory responses in both human primary cell culture and a mouse model. CC16 mRNA levels inversely correlated with MUC5AC which was supported by the CC16 knockdown experiments, and significantly associated with clinically relevant asthma outcomes.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kraft, M., Ledford, J., Gozdz, J., Li, X., Francisco, D., Manne, A., Guerra, S., Martinez, F., Kaminski, N., Wenzel, S., Meyers, D., Bleecker, E. Tags: Clinical Problems Source Type: research
PDK1/RSK1-dependent C/EBP{beta} activation is involved in thrombin-induced expression of orosomucoid 1-like 3 (ORMDL3) and IL-8/CXCL8 in human lung epithelial cells
In this study, we investigated that the role of phosphoinositide-dependent kinase 1 (PDK1), ribosomal S6 kinase 1 (RSK1), and CCAAT/enhancer-binding protein β (C/EBPβ) in thrombin-induced expression of ORMDL3 and IL-8/CXCL8 in human lung epithelial cells (A549). We found that treatment of cells with thrombin caused ORMDL3 mRNA and protein expression. Thrombin-induced IL-8/CXCL8-luciferase activity or IL-8/CXCL8 release was inhibited by ORMDL3 siRNA, BX-912 (a PDK1 inhibitor), and PDK1 siRNA. Moreover, thrombin-stimulated ORMDL3 expression was attenuated by BX-912, PDK1 siRNA, RSK1 siRNA, and C/EBPβ siRNA. Th...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Chen, B.-C., Huang, M.-F. Tags: Airway Pharmacology and Treatment Source Type: research
Ribosomal protein S3 gene silencing protects against experimental allergic asthma
We reported here for the first time that RPS3 gene silencing ameliorates experimental allergic asthma, probably via interruption of NF-B activity, confirming RPS3 a novel therapeutic target for the treatment of allergic airway inflammation.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Dong, J., Liao, W., Peh, H. Y., Chan, T. K., Tan, W. S. D., Li, L., Wong, W. S. F. Tags: 5.3 Allergy and Immunology Source Type: research
