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Total 404 results found since Jan 2013.

TAT decorated siRNA polyplexes for inhalation delivery in anti-asthma therapy
Eur J Pharm Sci. 2023 Sep 16;190:106580. doi: 10.1016/j.ejps.2023.106580. Online ahead of print.ABSTRACTIn this work, a novel protonable copolymer was designed to deliver siRNA through the inhalation route, as an innovative formulation for the management of asthma. This polycation was synthesized by derivatization of α,β-poly(N-2-hydroxyethyl)D,L-aspartamide (PHEA) first with 1,2-Bis(3-aminopropylamino)ethane (bAPAE) and then with a proper amount of maleimide terminated poly(ethylene glycol) (PEG-MLB), with the aim to increase the superficial hydrophilicity of the system, allowing the diffusion trough the mucus layer. On...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Salvatore Emanuele Drago Marta Cabibbo Emanuela Fabiola Craparo Gennara Cavallaro Source Type: research

TAT Decorated siRNA Polyplexes For Inhalation Delivery in Anti-asthma Therapy
Eur J Pharm Sci. 2023 Sep 15:106580. doi: 10.1016/j.ejps.2023.106580. Online ahead of print.ABSTRACTIn this work, a novel protonable copolymer was designed to deliver siRNA through the inhalation route, as an innovative formulation for the management of asthma. This polycation was synthesized by derivatization of α,β-poly(N-2-hydroxyethyl)D,L-aspartamide (PHEA) first with 1,2-Bis(3-aminopropylamino)ethane (bAPAE) and then with a proper amount of maleimide terminated poly(ethylene glycol) (PEG-MLB), with the aim to increase the superficial hydrophilicity of the system, allowing the diffusion trough the mucus layer. Once t...
Source: European Journal of Pharmaceutical Sciences - September 17, 2023 Category: Drugs & Pharmacology Authors: Salvatore Emanuele Drago Marta Cabibbo Emanuela Fabiola Craparo Gennara Cavallaro Source Type: research

Myeloid-associated differentiation marker is associated with type 2 asthma and is upregulated by human rhinovirus infection
ConclusionsOur studies show that in a mouse model of asthma and during RV-1B infection of primary human AECs, increased MYADM expression is observed. In the mouse model of asthma, MYADM expression was predominantly on the luminal side of airway epithelial cells. Additionally, MYADM expression was strongly associated with increases in inflammatory genes, which may contribute to more severe asthma and RV-linked asthma exacerbations.
Source: Frontiers in Immunology - August 11, 2023 Category: Allergy & Immunology Source Type: research

Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway
CONCLUSIONS: Increased sputum CST1 may play a key role in the pathogenesis of asthma through involvement in eosinophilic and type 2 inflammation through activation of the AKT signaling pathway, further promoting SERPINB2 expression. Therefore, targeting CST1 might be of therapeutic value in treating asthma with severe and eosinophilic phenotypes.PMID:37075800
Source: Allergy, Asthma and Immunology Research - April 19, 2023 Category: Allergy & Immunology Authors: Lijuan Du Changyi Xu Kun Tang Jia Shi Lu Tang Xiao Lisha Chengcheng Lei Huicong Liu Yuxia Liang Yubiao Guo Source Type: research

IRAK-M has effects in regulation of lung epithelial inflammation
CONCLUSION: Our findings suggested that IRAK-M has effect on lung epithelial inflammation with an influence on epithelial secretion of CXCL10 partly mediated through JNK and p38 MAPK pathways. IRAK-M modulation might indicate a new insight into asthma pathogenesis from disease origin.PMID:37029363 | DOI:10.1186/s12931-023-02406-5
Source: Respiratory Care - April 7, 2023 Category: Respiratory Medicine Authors: Jia Li Zhoude Zheng Yi Liu Hongbing Zhang Youming Zhang Jinming Gao Source Type: research