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Source: Pathology Research and Practice
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Total 48 results found since Jan 2013.
High-expressed CKS2 is associated with hepatocellular carcinoma cell proliferation though down-regulating PTEN
Conclusion These findings indicated that CKS2 play a role in tumor activation and serve as a useful potential target for the treatment of HCC.
Source: Pathology Research and Practice - December 31, 2017 Category: Pathology Source Type: research
CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation, invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - December 22, 2017 Category: Pathology Source Type: research
CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation,invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - November 19, 2017 Category: Pathology Source Type: research
Overexpression of microRNA-495 improves the intestinal mucosal barrier function by targeting STAT3 via inhibition of the JAK/STAT3 signaling pathway in a mouse model of ulcerative colitis
Publication date: Available online 12 October 2017 Source:Pathology - Research and Practice Author(s): Xian-Qun Chu, Jing Wang, Guang-Xiang Chen, Guan-Qi Zhang, De-Yong Zhang, Yong-Yan Cai We aim to investigate the role of microRNA-495 (miR-495) in the intestinal mucosal barrier by indirectly targeting signal transducer and activator of transcription 3 (STAT3) through the Janus kinase-signal transducer and activator of transcription (JAK)/STAT3 signaling pathway in a mouse model of ulcerative colitis (UC). BALB/c mice were selected for establishing a mice model of UC, and intestinal tissues of normal and UC mice were coll...
Source: Pathology Research and Practice - October 13, 2017 Category: Pathology Source Type: research
Knockdown of PINCH-1 protein sensitizes the Estrogen positive breast cancer cells to chemotherapy induced apoptosis
Conclusion The results suggest that PINCH-1 may be playing an important role in etiopathogenesis of both subtypes breast cancer. However, enhanced apoptosis observed only in estrogen positive and not in estrogen negative cells upon PINCH-1 knockdown point towards participation of some other protein with redundant functions in the later subtype which needs to be investigated.
Source: Pathology Research and Practice - September 30, 2017 Category: Pathology Source Type: research
Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma
Publication date: Available online 12 September 2017 Source:Pathology - Research and Practice Author(s): Takeharu Imai, Naohide Oue, Yuji Yamamoto, Ryuichi Asai, Naohiro Uraoka, Kazuhiro Sentani, Kazuhiro Yoshida, Wataru Yasui Esophageal squamous cell carcinoma (ESCC) is one of the most common human cancers. We previously reported that KIFC1 is involved in gastric cancer pathogenesis and that KIFC1 plays an important role in gastric cancer spheroid colony formation. However, the significance of KIFC1 in ESCC has not been examined. In the present study, we analyzed the expression and distribution of KIFC1 in 132 ESCC cases...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research
Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma
Publication date: Available online 8 September 2017 Source:Pathology - Research and Practice Author(s): Chun Li, Liwei Sun, Rui Jiang, Peng Wang, Haogang Xue, Yudong Zhan, Xiaodong Gai Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or wes...
Source: Pathology Research and Practice - September 9, 2017 Category: Pathology Source Type: research
AEG-1 mRNA expression in non-small cell lung cancer is associated with increased tumor angiogenesis
Publication date: Available online 7 September 2017 Source:Pathology - Research and Practice Author(s): Zhihong Ma, Yingrong Chen, Shunli Dong, Xuting Xu, Jin Liu, Pengtao Song, Caihua Yu, Licheng Dai Astrocyte-elevated gene-1 (AEG-1) is implicated in the oncogenesis and angiogenesis of various types of human malignant disease. However, the angiogenesis roles of AEG-1 in non-small cell lung cancer (NSCLC) remain to be further elucidated. In the present study, the expression level of AEG-1 mRNA in seven human lung cell lines and 89 paired tissue samples (tumor tissues (TTs) and pair-matched normal adjacent tissues (PMNATs)...
Source: Pathology Research and Practice - September 8, 2017 Category: Pathology Source Type: research
Forkhead box protein A2, a pioneer factor for hepatogenesis, is involved in the expression of hepatic phenotype of alpha-fetoprotein-producing adenocarcinoma
Publication date: Available online 23 July 2017 Source:Pathology - Research and Practice Author(s): Nobuhisa Yamamura, Kazunori Fugo, Takashi Kishimoto Alpha-fetoprotein (AFP)-producing adenocarcinoma is a high-malignant variant of adenocarcinoma with a hepatic or fetal-intestinal phenotype. The number of cases of AFP-producing adenocarcinomas is increasing, but the molecular mechanism underlying the aberrant production of AFP is unclear. Here we sought to assess the role of Forkhead box A (FoxA)2, which is a pioneer transcription factor in the differentiation of hepatoblasts. FoxA2 expression was investigated in five cas...
Source: Pathology Research and Practice - July 24, 2017 Category: Pathology Source Type: research
Gpx 4 is involved in the proliferation, migration and apoptosis of glioma cells
In this report, we defined Gpx4 as a therapeutic target for glioma. Western blot and immunohistochemistry(IHC) analysis revealed that the protein level of Gpx4 was higher in glioma tissues and cell lines. In addition, IHC stain revealed that there was statistical significance between the expression of Gpx4 and the WHO grade (P=0.004) and Ki-67(P=0.000) expression. Kaplan–Meier curve showed that high expression of Gpx4 was associated with poor prognosis of glioma patients (P <0.01). To determine whether Gpx4 could regulate the proliferation and migration of glioma cells, we transfected glioma cells with Gpx4-siRNA ...
Source: Pathology Research and Practice - May 5, 2017 Category: Pathology Source Type: research
Involvement of Prolyl Isomerase PIN1 in the Cell Cycle Progression and Proliferation of Hepatic Oval Cells
In conclusion, Pin1 plays important role in the cell cycle progression and increase oval cells proliferation which may be crucial in chronic liver injury.
Source: Pathology Research and Practice - January 18, 2017 Category: Pathology Source Type: research
PRDM5 promotes the apoptosis of epithelial cells induced by IFN- γ during Crohn’s disease
In this study, we investigated PRDM5 expression and its potential functions in both human CD (Crohn’s disease) and TNBS (2,4,6-trinitrobenzenesulfonic acid sol)-induced mice experimental colitis. As shown by western blot and immunohistochemistry, significant up-regulation of PRDM5 was found in the inflamed intestinal tissues of CD patients and TNBS-treated mice, and the molecule was mainly located in IECs. To explore the biological functions of PRDM5 in IEC apoptosis, we established the interferon-γ (IFN-γ) induced cellular apoptosis model on human IEC line HT29 in vitro. IFN-γ significantly increased the expression o...
Source: Pathology Research and Practice - December 6, 2016 Category: Pathology Source Type: research
San Huang Decoction downregulates Aurora kinase A to inhibit breast cancer cell growth and enhance chemosenstivity to anti-tumor drugs
Publication date: Available online 18 May 2016 Source:Pathology - Research and Practice Author(s): Yanlei Xu, Xu Chen, Xiyan Chen, Weihe Bian, Chang Yao, Xiaoqing Zhang, Xiaoshu Zhu, Jiajing Chen, Xiaozhou Ye Our study aimed to explore whether San Huang Decoction (SHD) inhibited the development of breast cancer by regulating Aurora A. Human breast cancer cell lines MCF-7 and MDA-MB-231 were cultured and SHD extract was prepared. Cell growth assay and apoptosis analysis were respectively performed to detect the effects of SHD on breast cancer cells. In addition, the effects of SHD on the expression of Aurora A an...
Source: Pathology Research and Practice - May 17, 2016 Category: Pathology Source Type: research
Liver X receptor activation inhibits PC-3 prostate cancer cells via the beta-catenin pathway
Conclusions This study provided additional evidence that LXR activation inhibited PC-3 prostate cancer cells via suppressing beta-catenin pathway.
Source: Pathology Research and Practice - May 11, 2016 Category: Pathology Source Type: research
Downregulated DYRK2 expression is associated with poor prognosis and Oxaliplatin resistance in hepatocellular carcinoma
Publication date: Available online 7 January 2016 Source:Pathology - Research and Practice Author(s): Xiubing Zhang, Pan Xu, Wenkai Ni, Hui Fan, Jian Xu, Yongmei Chen, Wei Huang, Shumin Lu, Li Liang, Jinxia Liu, Buyou Chen, Weidong Shi We aimed to investigate the molecular mechanisms of DYRK2 and the HCC sensitivity to Oxaliplatin in DYRK2-depleted HCC cells. HCC tissue specimens were obtained from 86 HCC patients during hepatectomy. We used immunohistochemistry and western blot to analyze DYRK2 expression in HCC tissues and cell lines, and used siRNA transfection to decrease DYRK2 expression in HCC cells. Fl...
Source: Pathology Research and Practice - January 22, 2016 Category: Pathology Source Type: research
