Filtered By:
Source: Pathology Research and Practice
This page shows you your search results in order of date.
Order by Relevance | Date
Total 48 results found since Jan 2013.
Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis
ConclusionsLncRNA TUG1 plays an oncogenic role in human PCa cells by promoting the cell proliferation and invasion in PCa cell lines, at least partly via the Nrf2 signaling pathway.
Source: Pathology Research and Practice - February 6, 2020 Category: Pathology Source Type: research
Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis
ConclusionElevated AEBP1 is positively associated with poor prognosis of glioma. AEBP1 downregulation suppressed cell proliferation and invasion, but promoted early cell apoptosis. AEBP1 downregulation suppressed the cell proliferation and invasion may by inhibiting the NF-κB signaling pathway.
Source: Pathology Research and Practice - December 18, 2019 Category: Pathology Source Type: research
miR-452 promotes the development of gastric cancer via targeting EPB41L3
In this study, we found that miR-452 was highly expressed in both tumor tissue and gastric cancer cells, and could directly target the cancer suppressor gene EPB41L3 3′-UTR. miR-452 significantly promoted the proliferation, migration and the S-phase arrest of gastric cancer cells, but EPB41L3 as a downstream target gene of miR-452 reversed such promoting effect. While down-regulation of miR-452 expression significantly inhibited the malignant biological behavior of gastric cancer cells, but this inhibitory effect was reversed by EPB41L3 siRNA. In addition, miR-452 in the gastric cancer xenograft model in nude mice could ...
Source: Pathology Research and Practice - November 1, 2019 Category: Pathology Source Type: research
PDRG1 gene silencing contributes to inhibit the growth and induce apoptosis of gastric cancer cells
ConclusionSpecific PDRG1 gene silencing may inhibit the growth and metastasis of gastric cancer cells through the activation of ATM/p53 pathway.
Source: Pathology Research and Practice - July 28, 2019 Category: Pathology Source Type: research
Decreased IL-6 induces sensitivity of hepatocellular carcinoma cells to sorafenib
Publication date: Available online 25 July 2019Source: Pathology - Research and PracticeAuthor(s): Jing Yang, Jiali Wang, Jialin LuoAbstractSorafenib has been recommended as a new palliative therapy for advanced hepatocellular carcinoma (HCC). However, the sensitivity of HCC cells to sorafenib is declined along with the extension of medication time, and the clinical outcome varies with patients receiving sorafenib therapy. Therefore, in the present study, we attempted to investigate the effect and mechanisms of IL-6 on sensitivity of HCC cells to sorafenib regarding the cell proliferation and apoptosis. Tissues from patien...
Source: Pathology Research and Practice - July 25, 2019 Category: Pathology Source Type: research
Participation of tumor suppressors long non-coding RNA MEG3, microRNA-377 and PTEN in glioma cell invasion and migration
ConclusionsThese results suggested the link interaction of MEG3 with miR-377 and PTEN, but not functioning as the competing endogenous RNA. MiR-377 mimics and MEG3 were tumor suppressors in glioma cells through regulating PTEN expression.
Source: Pathology Research and Practice - July 24, 2019 Category: Pathology Source Type: research
Kmt2c modulates migration and invasion processes in osteosarcoma cell lines
In this study we investigated the role of KMT2C (a chromatin-modifying and remodelling protein) in osteosarcoma progression through cell migration and invasion assays in osteosarcoma primary and metastatic cell lines. Wound healing and transwell assays were used to detect changes of cell migration and matrigel assay was used to evaluate changes of cell invasion in primary and metastatic osteosarcoma cell lines after KMT2C siRNA transfection. We found that primary osteosarcoma cell lines showed the highest capacity of migration before mRNA KMT2C silencing and the highest capacity of invasion after mRNA KMT2C silencing; on t...
Source: Pathology Research and Practice - July 13, 2019 Category: Pathology Source Type: research
TCF12 overexpression as a poor prognostic factor in ovarian cancer
ConclusionThe results suggest that TCF12 is a poor prognostic factor of ovarian cancer and that targeting TCF12 may be a new therapeutic strategy for ovarian cancer treatment.
Source: Pathology Research and Practice - July 8, 2019 Category: Pathology Source Type: research
Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335
ConclusionOur study demonstrates that circ-EIF4G3 promotes the proliferation, invasion and migration of gastric cancer via sponging miR-335.
Source: Pathology Research and Practice - June 22, 2019 Category: Pathology Source Type: research
miR-17 regulates the proliferation and apoptosis of endothelial cells in coronary heart disease via targeting insulin-like-growth factor 1
Publication date: Available online 20 June 2019Source: Pathology - Research and PracticeAuthor(s): Zhongpu Chen, Xiaodong Pan, Zulong Sheng, Gaoliang Yan, Long Chen, Genshan MaAbstractCoronary heart disease (CHD) is one of the main risks of death, which is mainly caused by coronary arteries arteriosclerosis. The present study aims to investigate the potential roles of miR-17 in CHD. In the present study, Human umbilical vascular endothelial cells (HUVECs) were treated with oxidized low density lipoprotein (ox-LDL). qRT-PCR and western blot were used to examine the mRNA and protein levels, respectively. CCK-8 and flow cytom...
Source: Pathology Research and Practice - June 22, 2019 Category: Pathology Source Type: research
Upregulation of miR‑95-3p inhibits growth of osteosarcoma by targeting HDGF
Publication date: Available online 10 June 2019Source: Pathology - Research and PracticeAuthor(s): Xiwei Liu, Wei Ma, Jianbing Ma, Lin Xiao, Dingjun HaoAbstractOsteosarcoma is the most common bone malignancy and miR-95-3p plays an important role in multiple cancers. The purpose of this study was to explore the effect and potential mechanism of miR-95-3p on the growth of osteosarcoma. In vitro, the osteosarcoma cell lines, SAOS-2 and U2OS cells, were transfected with miR-95-agomir to assess the role of miR-95-3p in proliferation and apoptosis of osteosarcoma cells. We determined that overexpression of miR-95-3p significantl...
Source: Pathology Research and Practice - June 11, 2019 Category: Pathology Source Type: research
DAAM1-mediated migration and invasion of ovarian cancer cells are suppressed by miR-208a-5p
Publication date: Available online 14 May 2019Source: Pathology - Research and PracticeAuthor(s): Jie Mei, Yifu Huang, Leiyu Hao, Yan Liu, Ting Yan, Tonglu Qiu, Rui Xu, Bujie Xu, Zhuang Xiao, Xiaozheng Jiang, Kehan Hu, Yichao ZhuAbstractOvarian cancer (OvCa) has the highest morbidity among all gynecologic cancers worldwide, and its distant metastasis is one of main causes for the poor prognosis of OvCa patients. Our previous studies have reported that DAAM1-involved signaling pathways play vital roles in metastasis of breast cancer. However, whether DAAM1 participates in OvCa migration and/or invasion is still unknown. The...
Source: Pathology Research and Practice - May 14, 2019 Category: Pathology Source Type: research
SOX11 promotes osteoarthritis through induction of TNF-α
ConclusionInhibition of SOX11 could improve IL-1β-induced OA like phenomenon in CHON-001 cells, which suggesting SOX11 played an important role during the pathogenesis of OA. Thus, we hypothesized that SOX11 could be a potential target for the treatment of patients with OA.
Source: Pathology Research and Practice - May 7, 2019 Category: Pathology Source Type: research
Cyclophilin B promotes cell proliferation, migration, invasion and angiogenesis via regulating the STAT3 pathway in non-small cell lung cancer
This study aimed to investigate the role and regulatory mechanism of CypB in NSCLC progression. The expression levels of CypB was detected in NSCLC samples and cell lines by ELISA, western blot and immunohistochemistry assay. In addition, CCK8, colony formation, scratch and transwell assays were used to evaluate the proliferation, migration and invasion of A549 cells with CypB silencing. The expression of angiogenesis related proteins and pathway-related factors were detected by western blot. In NSCLC samples, CypB expression was upregulated. The expression of CypB was significantly reduced in the siRNA-cyclophilin B group...
Source: Pathology Research and Practice - April 18, 2019 Category: Pathology Source Type: research
EZH2 promotes gastric cancer cells proliferation by repressing p21 expression
In this study, immunohistochemical analysis was conducted to investigate the EZH2 expression in gastric cancer. We found that EZH2 levels were increased in gastric cancer tissues compared with adjacent normal tissues. Moreover, patients with high levels of EZH2 expression had a relatively poor prognosis. Furthermore, knockdown of EZH2 expression by siRNA could impair cell proliferation and invasion both in vitro and vivo. Finally, we found that EZH2 influences gastric cancer cells proliferation partly through regulating p21 expression. Our findings present that EZH2 over-expression can be identified as a poor prognostic bi...
Source: Pathology Research and Practice - March 6, 2019 Category: Pathology Source Type: research
