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Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
In this study, we applied bioinformatics methods and found that USP22 was correlated with the heat shock protein 90 (HSP90) which is now considered to be a biomarker to predict the prognosis of gastric cancer. Then the siRNA transfection and western blotting were used to testify the correlation of USP22 and HSP90 in gastric cancer cells. The immunohistochemistry staining of the microarrays was applied to confirm the correlation of USP22 and HSP90 expression in gastric cancer tissue and further analysis showed that co-expression of USP22 and HSP90 was related to lymph node metastasis and more effective in predicting the pro...
Source: Pathology Research and Practice - December 26, 2018 Category: Pathology Source Type: research

Regulation between two alternative splicing isoforms ZNF148FL and ZNF148ΔN, and their roles in the apoptosis and invasion of colorectal cancer
ConclusionZNF148FL could increase proliferation, invasion, and migration of CRC cells, while ZNF148ΔN showed opposite effect; the two splicing isoforms of ZNF148 may exert a mutual antagonistic effect to each other on the malignant biological activities.
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

Loss of BMP-10 is correlated with poor survival in ovarian cancer
ConclusionLow BMP-10 expression was associated with poor prognosis and progression of ovarian cancer.
Source: Pathology Research and Practice - October 29, 2018 Category: Pathology Source Type: research

Cell Division Cycle Associated 7 Like Predicts Unfavorable Prognosis and Promotes Invasion in Glioma
ConclusionsCDCA7L is highly expressed in human glioma tissues and a high CDCA7L expression level predicts the dismal prognosis for glioma patients. Moreover, CDCA7L can promote glioma invasion, which can serve as an independent potential prognostic biomarker for glioma patients.
Source: Pathology Research and Practice - October 24, 2018 Category: Pathology Source Type: research

Knockdown of DSPP inhibits the migration and invasion of glioma cells
In this study, we aimed to investigate the expression and biological function of DSPP in human glioma cells. We demonstrated through Western blot that DSPP is overexpressed in glioma tissues comparing to normal brain tissues. To investigate the role of DSPP in glioma carcinogenesis, we reduced the DSPP expression by small interfering RNA (siRNA) and found that DSPP silencing significantly inhibited the migration and invasion of glioma cells, the critical characteristics of glioma. Furthermore, we showed that DSPP down-regulation significantly decreased the activation of the AKT/mTOR/p70S6K pathway in glioma cells. Taken to...
Source: Pathology Research and Practice - October 5, 2018 Category: Pathology Source Type: research

Tumor-associated macrophages promote the metastasis of ovarian carcinoma cells by enhancing CXCL16/CXCR6 expression
This study investigated the underlying mechanism by which C-X-C motif chemokine ligand 16 (CXCL16)/C-X-C motif chemokine receptor 6 (CXCR6) signaling is activated by tumor-associated macrophages and assists in regulating the metastasis of ovarian carcinoma. Specimens of ovarian carcinoma tissue and adjacent tissue were collected from 20 ovarian carcinoma patients. Human THP-1 cells were induced to differentiate into macrophages, which were then co-cultured with SKOV3 cells and low concentrations of tumor necrosis factor-α (TNF-α) to simulate the inflammatory microenvironment of ovarian carcinoma. Additionally, small inte...
Source: Pathology Research and Practice - July 12, 2018 Category: Pathology Source Type: research

Macrophage migration inhibitory factor is a novel prognostic marker for human oral squamous cell carcinoma
The objective of this study was to investigate the expression of MIF and its receptor CD74 in OSCC tissues, and to study the function of MIF in OSCC cells. Tissues of 90 patients with OSCC from the School of Stomatology, China Medical University were collected, and immunohistochemical staining and quantitative reverse transcription polymerase chain reaction were performed for MIF and CD74. The possible correlations between MIF and CD74 and clinical characteristics were analysed. The Kaplan-Meier analysis was used to determine the survival rates of patients. In addition, the proliferation and invasion of OSCC cells were eva...
Source: Pathology Research and Practice - July 10, 2018 Category: Pathology Source Type: research

Knockdown of TRIM66 inhibits malignant behavior and epithelial-mesenchymal transition in non-small cell lung cancer
ConclusionSilence TRIM66 expression suppressed NSCLC cell proliferation, invasion, and migration. The siRNA-mediated TRIM66 silencing could block the occurrence of EMT. TRIM66 could be a promising novel target for future NSCLC treatments.
Source: Pathology Research and Practice - July 10, 2018 Category: Pathology Source Type: research

IL-1β promotes the migration of olfactory epithelium neural stem cells through activating matrix metalloproteinase expressions
ConclusionOur study demonstrated that IL-1β promoted the migration of OENSCs through activating MMP expression. Moreover, JNK and NF-κB signaling pathways were involved in the regulation. This study provides important experimental evidence for the application of OENSCs in the transplantation therapy.
Source: Pathology Research and Practice - July 10, 2018 Category: Pathology Source Type: research

Macrophage migration inhibitory factor is a novel prognostic marker for human oral squamous cell carcinoma
The objective of this study was to investigate the expression of MIF and its receptor CD74 in OSCC tissues, and to study the function of MIF in OSCC cells. Tissues of 90 patients with OSCC from the School of Stomatology, China Medical University were collected, and immunohistochemical staining and quantitative reverse transcription polymerase chain reaction were performed for MIF and CD74. The possible correlations between MIF and CD74 and clinical characteristics were analysed. The Kaplan-Meier analysis was used to determine the survival rates of patients. In addition, the proliferation and invasion of OSCC cells were eva...
Source: Pathology Research and Practice - July 5, 2018 Category: Pathology Source Type: research

Knockdown of TRIM66 inhibits malignant behavior and epithelial-mesenchymal transition in non-small cell lung cancer
ConclusionSilence TRIM66 expression suppressed NSCLC cell proliferation, invasion, and migration. The siRNA-mediated TRIM66 silencing could block the occurrence of EMT. TRIM66 could be a promising novel target for future NSCLC treatments.
Source: Pathology Research and Practice - July 5, 2018 Category: Pathology Source Type: research

High-expressed CKS2 is associated with hepatocellular carcinoma cell proliferation through down-regulating PTEN
Conclusion These findings indicated that CKS2 play a role in tumor activation and serve as a useful potential target for the treatment of HCC.
Source: Pathology Research and Practice - March 19, 2018 Category: Pathology Source Type: research

Bex1 attenuates neuronal apoptosis in rat intracerebral hemorrhage model
In this study, the roles of Bex1 were explored in the pathophysiology of ICH. Western blot, immunohistochemistry, and immunofluorescence showed that obvious up-regulation of Bex1 in neurons adjacent to the hematoma after ICH. Furthermore, the increase of Bex1 expression was accompanied by the enhanced expression of Bax and active caspase-3, and decreased expression of B-cell lymphoma 2 (Bcl-2) following ICH. The in vitro study using Bex1 siRNA transfection in hemin-exposed PC12 cells suggested that Bex1 exerted anti-apoptotic function. Therefore, Bex1 may play the neuronal anti-apoptosis role following ICH, implying a nove...
Source: Pathology Research and Practice - February 22, 2018 Category: Pathology Source Type: research

Up-regulated Expression of SNHG6 Predicts Poor Prognosis in Colorectal Cancer
Publication date: Available online 3 January 2018 Source:Pathology - Research and Practice Author(s): Min Li, Zehua Bian, Surui Yao, Jia Zhang, Guoying Jin, Xue Wang, Yuan Yin, Zhaohui Huang Long non-coding RNAs (lncRNAs) have been shown to play important roles in tumor formation and development. Small nucleolar RNA host gene 6 (SNHG6) is a recently identified cancer-related lncRNA, and its role in colorectal cancer (CRC) remains to be explored. The aim of this study was to evaluate the expression and function of SNHG6 in CRC. The expression of SNHG6 was detected by real time quantitative RT-PCR (qRT-PCR) in 74 CRC tissue...
Source: Pathology Research and Practice - January 3, 2018 Category: Pathology Source Type: research

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