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Source: Pathology Research and Practice

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Total 48 results found since Jan 2013.

Regulation between two alternative splicing isoforms ZNF148FL and ZNF148ΔN, and their roles in the apoptosis and invasion of colorectal cancer
ConclusionZNF148FL could increase proliferation, invasion, and migration of CRC cells, while ZNF148ΔN showed opposite effect; the two splicing isoforms of ZNF148 may exert a mutual antagonistic effect to each other on the malignant biological activities.
Source: Pathology Research and Practice - November 3, 2018 Category: Pathology Source Type: research

Overexpression of microRNA-495 improves the intestinal mucosal barrier function by targeting STAT3 via inhibition of the JAK/STAT3 signaling pathway in a mouse model of ulcerative colitis
Publication date: Available online 12 October 2017 Source:Pathology - Research and Practice Author(s): Xian-Qun Chu, Jing Wang, Guang-Xiang Chen, Guan-Qi Zhang, De-Yong Zhang, Yong-Yan Cai We aim to investigate the role of microRNA-495 (miR-495) in the intestinal mucosal barrier by indirectly targeting signal transducer and activator of transcription 3 (STAT3) through the Janus kinase-signal transducer and activator of transcription (JAK)/STAT3 signaling pathway in a mouse model of ulcerative colitis (UC). BALB/c mice were selected for establishing a mice model of UC, and intestinal tissues of normal and UC mice were coll...
Source: Pathology Research and Practice - October 13, 2017 Category: Pathology Source Type: research

PDRG1 gene silencing contributes to inhibit the growth and induce apoptosis of gastric cancer cells
ConclusionSpecific PDRG1 gene silencing may inhibit the growth and metastasis of gastric cancer cells through the activation of ATM/p53 pathway.
Source: Pathology Research and Practice - July 28, 2019 Category: Pathology Source Type: research

Knockdown of TRIM66 inhibits malignant behavior and epithelial-mesenchymal transition in non-small cell lung cancer
ConclusionSilence TRIM66 expression suppressed NSCLC cell proliferation, invasion, and migration. The siRNA-mediated TRIM66 silencing could block the occurrence of EMT. TRIM66 could be a promising novel target for future NSCLC treatments.
Source: Pathology Research and Practice - July 5, 2018 Category: Pathology Source Type: research

Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma
Publication date: Available online 12 September 2017 Source:Pathology - Research and Practice Author(s): Takeharu Imai, Naohide Oue, Yuji Yamamoto, Ryuichi Asai, Naohiro Uraoka, Kazuhiro Sentani, Kazuhiro Yoshida, Wataru Yasui Esophageal squamous cell carcinoma (ESCC) is one of the most common human cancers. We previously reported that KIFC1 is involved in gastric cancer pathogenesis and that KIFC1 plays an important role in gastric cancer spheroid colony formation. However, the significance of KIFC1 in ESCC has not been examined. In the present study, we analyzed the expression and distribution of KIFC1 in 132 ESCC cases...
Source: Pathology Research and Practice - September 13, 2017 Category: Pathology Source Type: research

Overexpression of CCT8 and its significance for tumor cell proliferation, migration and invasion in Glioma
This study showed that high CCT8 protein expression might be related to poor outcome of glioma, and that CCT8 regulates the proliferation and invasion of glioblastomas.
Source: Pathology Research and Practice - May 19, 2015 Category: Pathology Source Type: research

Downregulation of FOXP3 inhibits cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma
Publication date: Available online 8 September 2017 Source:Pathology - Research and Practice Author(s): Chun Li, Liwei Sun, Rui Jiang, Peng Wang, Haogang Xue, Yudong Zhan, Xiaodong Gai Our study aimed to investigate the biological role of FOXP3 expression in human lung adenocarcinoma (LAD) tissues and evaluate its involvement in cell proliferation and chemosensitivity to cisplatin in LAD cells. Paraffin-embedded tissues from 50 LAD patients were collected to detect FOXP3 and Ki-67 expression using immunohistochemistry (IHC). Downregulation of FOXP3 in A549 cells was performed using siRNA transfection. Real-time PCR or wes...
Source: Pathology Research and Practice - September 9, 2017 Category: Pathology Source Type: research

CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation,invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - November 19, 2017 Category: Pathology Source Type: research

CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation, invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - December 22, 2017 Category: Pathology Source Type: research

Cell Division Cycle Associated 7 Like Predicts Unfavorable Prognosis and Promotes Invasion in Glioma
ConclusionsCDCA7L is highly expressed in human glioma tissues and a high CDCA7L expression level predicts the dismal prognosis for glioma patients. Moreover, CDCA7L can promote glioma invasion, which can serve as an independent potential prognostic biomarker for glioma patients.
Source: Pathology Research and Practice - October 24, 2018 Category: Pathology Source Type: research

miR-17 regulates the proliferation and apoptosis of endothelial cells in coronary heart disease via targeting insulin-like-growth factor 1
Publication date: Available online 20 June 2019Source: Pathology - Research and PracticeAuthor(s): Zhongpu Chen, Xiaodong Pan, Zulong Sheng, Gaoliang Yan, Long Chen, Genshan MaAbstractCoronary heart disease (CHD) is one of the main risks of death, which is mainly caused by coronary arteries arteriosclerosis. The present study aims to investigate the potential roles of miR-17 in CHD. In the present study, Human umbilical vascular endothelial cells (HUVECs) were treated with oxidized low density lipoprotein (ox-LDL). qRT-PCR and western blot were used to examine the mRNA and protein levels, respectively. CCK-8 and flow cytom...
Source: Pathology Research and Practice - June 22, 2019 Category: Pathology Source Type: research

Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis
ConclusionElevated AEBP1 is positively associated with poor prognosis of glioma. AEBP1 downregulation suppressed cell proliferation and invasion, but promoted early cell apoptosis. AEBP1 downregulation suppressed the cell proliferation and invasion may by inhibiting the NF-κB signaling pathway.
Source: Pathology Research and Practice - December 18, 2019 Category: Pathology Source Type: research

A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival
Publication date: December 2014 Source:Pathology - Research and Practice, Volume 210, Issue 12 Author(s): Fang Liu , Changlai Zhu , Xiaodong Huang , Jing Cai , Hua Wang , Xinxiu Wang , Song He , Cheng Liu , Xiaojing Yang , Yixin Zhang , Tianyi Zhang GPR37, also known as parkin-associated endothelin-like receptor (Pael-R), is an orphan G protein-coupled receptor (GPCR). It has been reported that GPCRs play vital roles in the development and progression of cancer. To investigate the potential roles of GPR37 in hepatocellular carcinoma (HCC), expression of GPR37 was examined in human HCC samples. Immunohistochemistry and We...
Source: Pathology Research and Practice - December 2, 2014 Category: Pathology Source Type: research

High expression of vacuolar protein sorting 4B (VPS4B) is associated with accelerated cell proliferation and poor prognosis in human hepatocellular carcinoma
In this study, we investigated the prognostic role of VPS4B in human hepatocellular carcinoma (HCC) and its effect on the growth of HCC cells. Western blot and immunohistochemistrical analyses revealed that VPS4B was significantly upregulated in 98 HCC tissues, compared with adjacent nontumorous samples. Meanwhile, clinicopathological variables and univariate and multivariate survival analyses showed that high VPS4B expression was correlated with multiple clinicopathological factors, including AJCC stage, microvascular invasion, Ki-67 and a poor prognosis. More importantly, univariate and multivariate survival analyses dem...
Source: Pathology Research and Practice - March 2, 2015 Category: Pathology Source Type: research