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Source: Pathology Research and Practice
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Total 48 results found since Jan 2013.
Macrophage migration inhibitory factor is a novel prognostic marker for human oral squamous cell carcinoma
The objective of this study was to investigate the expression of MIF and its receptor CD74 in OSCC tissues, and to study the function of MIF in OSCC cells. Tissues of 90 patients with OSCC from the School of Stomatology, China Medical University were collected, and immunohistochemical staining and quantitative reverse transcription polymerase chain reaction were performed for MIF and CD74. The possible correlations between MIF and CD74 and clinical characteristics were analysed. The Kaplan-Meier analysis was used to determine the survival rates of patients. In addition, the proliferation and invasion of OSCC cells were eva...
Source: Pathology Research and Practice - July 10, 2018 Category: Pathology Source Type: research
IL-1β promotes the migration of olfactory epithelium neural stem cells through activating matrix metalloproteinase expressions
ConclusionOur study demonstrated that IL-1β promoted the migration of OENSCs through activating MMP expression. Moreover, JNK and NF-κB signaling pathways were involved in the regulation. This study provides important experimental evidence for the application of OENSCs in the transplantation therapy.
Source: Pathology Research and Practice - July 10, 2018 Category: Pathology Source Type: research
Tumor-associated macrophages promote the metastasis of ovarian carcinoma cells by enhancing CXCL16/CXCR6 expression
This study investigated the underlying mechanism by which C-X-C motif chemokine ligand 16 (CXCL16)/C-X-C motif chemokine receptor 6 (CXCR6) signaling is activated by tumor-associated macrophages and assists in regulating the metastasis of ovarian carcinoma. Specimens of ovarian carcinoma tissue and adjacent tissue were collected from 20 ovarian carcinoma patients. Human THP-1 cells were induced to differentiate into macrophages, which were then co-cultured with SKOV3 cells and low concentrations of tumor necrosis factor-α (TNF-α) to simulate the inflammatory microenvironment of ovarian carcinoma. Additionally, small inte...
Source: Pathology Research and Practice - July 12, 2018 Category: Pathology Source Type: research
Knockdown of DSPP inhibits the migration and invasion of glioma cells
In this study, we aimed to investigate the expression and biological function of DSPP in human glioma cells. We demonstrated through Western blot that DSPP is overexpressed in glioma tissues comparing to normal brain tissues. To investigate the role of DSPP in glioma carcinogenesis, we reduced the DSPP expression by small interfering RNA (siRNA) and found that DSPP silencing significantly inhibited the migration and invasion of glioma cells, the critical characteristics of glioma. Furthermore, we showed that DSPP down-regulation significantly decreased the activation of the AKT/mTOR/p70S6K pathway in glioma cells. Taken to...
Source: Pathology Research and Practice - October 5, 2018 Category: Pathology Source Type: research
Loss of BMP-10 is correlated with poor survival in ovarian cancer
ConclusionLow BMP-10 expression was associated with poor prognosis and progression of ovarian cancer.
Source: Pathology Research and Practice - October 29, 2018 Category: Pathology Source Type: research
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
In this study, we applied bioinformatics methods and found that USP22 was correlated with the heat shock protein 90 (HSP90) which is now considered to be a biomarker to predict the prognosis of gastric cancer. Then the siRNA transfection and western blotting were used to testify the correlation of USP22 and HSP90 in gastric cancer cells. The immunohistochemistry staining of the microarrays was applied to confirm the correlation of USP22 and HSP90 expression in gastric cancer tissue and further analysis showed that co-expression of USP22 and HSP90 was related to lymph node metastasis and more effective in predicting the pro...
Source: Pathology Research and Practice - December 26, 2018 Category: Pathology Source Type: research
EZH2 promotes gastric cancer cells proliferation by repressing p21 expression
In this study, immunohistochemical analysis was conducted to investigate the EZH2 expression in gastric cancer. We found that EZH2 levels were increased in gastric cancer tissues compared with adjacent normal tissues. Moreover, patients with high levels of EZH2 expression had a relatively poor prognosis. Furthermore, knockdown of EZH2 expression by siRNA could impair cell proliferation and invasion both in vitro and vivo. Finally, we found that EZH2 influences gastric cancer cells proliferation partly through regulating p21 expression. Our findings present that EZH2 over-expression can be identified as a poor prognostic bi...
Source: Pathology Research and Practice - March 6, 2019 Category: Pathology Source Type: research
Cyclophilin B promotes cell proliferation, migration, invasion and angiogenesis via regulating the STAT3 pathway in non-small cell lung cancer
This study aimed to investigate the role and regulatory mechanism of CypB in NSCLC progression. The expression levels of CypB was detected in NSCLC samples and cell lines by ELISA, western blot and immunohistochemistry assay. In addition, CCK8, colony formation, scratch and transwell assays were used to evaluate the proliferation, migration and invasion of A549 cells with CypB silencing. The expression of angiogenesis related proteins and pathway-related factors were detected by western blot. In NSCLC samples, CypB expression was upregulated. The expression of CypB was significantly reduced in the siRNA-cyclophilin B group...
Source: Pathology Research and Practice - April 18, 2019 Category: Pathology Source Type: research
SOX11 promotes osteoarthritis through induction of TNF-α
ConclusionInhibition of SOX11 could improve IL-1β-induced OA like phenomenon in CHON-001 cells, which suggesting SOX11 played an important role during the pathogenesis of OA. Thus, we hypothesized that SOX11 could be a potential target for the treatment of patients with OA.
Source: Pathology Research and Practice - May 7, 2019 Category: Pathology Source Type: research
DAAM1-mediated migration and invasion of ovarian cancer cells are suppressed by miR-208a-5p
Publication date: Available online 14 May 2019Source: Pathology - Research and PracticeAuthor(s): Jie Mei, Yifu Huang, Leiyu Hao, Yan Liu, Ting Yan, Tonglu Qiu, Rui Xu, Bujie Xu, Zhuang Xiao, Xiaozheng Jiang, Kehan Hu, Yichao ZhuAbstractOvarian cancer (OvCa) has the highest morbidity among all gynecologic cancers worldwide, and its distant metastasis is one of main causes for the poor prognosis of OvCa patients. Our previous studies have reported that DAAM1-involved signaling pathways play vital roles in metastasis of breast cancer. However, whether DAAM1 participates in OvCa migration and/or invasion is still unknown. The...
Source: Pathology Research and Practice - May 14, 2019 Category: Pathology Source Type: research
Upregulation of miR‑95-3p inhibits growth of osteosarcoma by targeting HDGF
Publication date: Available online 10 June 2019Source: Pathology - Research and PracticeAuthor(s): Xiwei Liu, Wei Ma, Jianbing Ma, Lin Xiao, Dingjun HaoAbstractOsteosarcoma is the most common bone malignancy and miR-95-3p plays an important role in multiple cancers. The purpose of this study was to explore the effect and potential mechanism of miR-95-3p on the growth of osteosarcoma. In vitro, the osteosarcoma cell lines, SAOS-2 and U2OS cells, were transfected with miR-95-agomir to assess the role of miR-95-3p in proliferation and apoptosis of osteosarcoma cells. We determined that overexpression of miR-95-3p significantl...
Source: Pathology Research and Practice - June 11, 2019 Category: Pathology Source Type: research
Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335
ConclusionOur study demonstrates that circ-EIF4G3 promotes the proliferation, invasion and migration of gastric cancer via sponging miR-335.
Source: Pathology Research and Practice - June 22, 2019 Category: Pathology Source Type: research
TCF12 overexpression as a poor prognostic factor in ovarian cancer
ConclusionThe results suggest that TCF12 is a poor prognostic factor of ovarian cancer and that targeting TCF12 may be a new therapeutic strategy for ovarian cancer treatment.
Source: Pathology Research and Practice - July 8, 2019 Category: Pathology Source Type: research
Kmt2c modulates migration and invasion processes in osteosarcoma cell lines
In this study we investigated the role of KMT2C (a chromatin-modifying and remodelling protein) in osteosarcoma progression through cell migration and invasion assays in osteosarcoma primary and metastatic cell lines. Wound healing and transwell assays were used to detect changes of cell migration and matrigel assay was used to evaluate changes of cell invasion in primary and metastatic osteosarcoma cell lines after KMT2C siRNA transfection. We found that primary osteosarcoma cell lines showed the highest capacity of migration before mRNA KMT2C silencing and the highest capacity of invasion after mRNA KMT2C silencing; on t...
Source: Pathology Research and Practice - July 13, 2019 Category: Pathology Source Type: research
Participation of tumor suppressors long non-coding RNA MEG3, microRNA-377 and PTEN in glioma cell invasion and migration
ConclusionsThese results suggested the link interaction of MEG3 with miR-377 and PTEN, but not functioning as the competing endogenous RNA. MiR-377 mimics and MEG3 were tumor suppressors in glioma cells through regulating PTEN expression.
Source: Pathology Research and Practice - July 24, 2019 Category: Pathology Source Type: research
