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Source: Oncology Research

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Total 108 results found since Jan 2013.

miR-203 inhibits the invasion and EMT of gastric cancer cells by directly targeting Annexin A4.
Authors: Li J, Zhang B, Cui J, Liang Z, Liu K Abstract Many studies have shown that down-regulated miR-203 level is in a variety of cancers including gastric cancer (GC). However, the precise molecule mechanisms of miR-203 in GC have not been well clarified. In current study, we investigated the biological functions and molecular mechanisms of miR-203 in GC cell lines. We found that miR-203 is down-regulated in GC tissues and cell lines. Moreover, the low level of miR-203 was associated with increased expression of Annexin A4 in GC tissues and cell lines. The invasion and EMT of GC cells was suppressed by overexpre...
Source: Oncology Research - March 7, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

NOTCH3 overexpression and post-transcriptional regulation by miR-150 were associated with EGFR-TKI resistance in lung adenocarcinoma.
Authors: Zhang Y, Chen B, Wang Y, Zhao Q, Wu W, Zhang P, Miao L, Sun S Abstract Acquired resistance remains a key challenge in epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) therapy in lung adenocarcinoma (LUAD). Recent studies have shown that Notch signaling is associated with drug resistance. However, its role and possible mechanisms in EGFR-TKI resistance are not yet clear. In our study, we found that among 4 members of NOTCH1-4, only NOTCH3 was up-regulated in LUAD tissues and TKI-resistant cell line (HCC827GR6). Knockdown of NOTCH3 by siRNA significantly inhibited proliferative abilit...
Source: Oncology Research - February 10, 2019 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MicroRNA-664 targets Insulin receptor substrate 1 to suppress cell proliferation and invasion in breast cancer.
This study showed that miR-664 expression was obviously reduced in BC tissues and cell lines. Resumption expression of miR-664 attenuated the proliferation and invasion of BC cells. The molecular mechanism underlying the inhibitory effects of BC cell proliferation and invasion by miR-664 was also studied. Insulin receptor substrate 1 (IRS1) was identified as a novel and direct target of miR-664. In addition, siRNA-mediated silencing of IRS1 expression mimicked the suppressive effects of miR-664 overexpression in BC cells. Rescue experiments demonstrated that recovered IRS1 expression partially antagonized the inhibition of...
Source: Oncology Research - March 3, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Silencing of NADPH oxidase 4 attenuates hypoxia resistance in neuroblastoma cells SHSY-5Y by inhibiting PI3K/Akt-dependent glycolysis.
Authors: Yu T, Li L, Liu W, Ya B, Cheng H, Xin Q Abstract Hypoxia-induced chemoresistance is a major obstacle in the development of effective cancer therapy. In our study, the reversal abilities of NADPH oxidase 4 (NOX4) silence on the hypoxia resistance and the potential mechanism were investigated. Our data showed that the expression of NOX4 was up-regulated in human neuroblastoma cells SHSY-5Y under hypoxia condition time-dependently. Knockdown of NOX4 expression by siRNA inhibited glycolysis induced by hypoxia through decreasing the expression of glycolysis related proteins (HIF-1α, LDHA, PDK1), decreasing glu...
Source: Oncology Research - February 11, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Phosphoglycerate mutase 1(PGAM1) promotes pancreatic ductal adenocarcinoma (PDAC) metastasis by acting as a novel downstream target of PI3K/Akt/mTOR pathway.
This study indicates that PGAM1 is closely associated with clinical metastasis and poor prognosis of PDAC. PGAM1 is considered as a potential therapeutic target in PDAC metastasis. PMID: 29386088 [PubMed - as supplied by publisher]
Source: Oncology Research - February 3, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

The downregulation of miR-200c promotes lactate dehydrogenase A expression and non-small cell lung cancer progression.
This study was aimed to investigate the function and mechanism of microRNA-200c (miR-200c) in the progression of non-small cell lung cancer (NSCLC). A total of 76 patients diagnosed as NSCLC were enrolled in this study. Then, the expression level of miR-200c in NSCLC tissues and cell lines was investigated using the quantitative realtime polymerase chain reaction (RT-qPCR) method. We found the expression of miR200c was significantly reduced in NSCLC tissues and cell lines compared with in normal lung tissues and human bronchial epithelial cell line. Force the expression of miR-200c using miR-200c mimic significantly suppre...
Source: Oncology Research - January 14, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

CD47 promotes human glioblastoma invasion through activation of PI3K/Akt pathway.
In this study we found that CD47 expression was stronger in glioblastoma patients and cells in comparison with normal controls. CD47 downregulation modulated by siRNA suppressed invasion in vitro. However, excessive CD47 expression modulated by transfection exerted opposite influence. In the meantime, excessive CD47 or knockdown CD47 expression had no effect on proliferation. Moreover, CD47 expression was related to AKT phosphorylation on cellular molecular level. AKT suppression with specific inhibitor impaired invasion of cells in which excessively expressed CD47, indicating that stimulation of PI3K/Akt pathway served as...
Source: Oncology Research - January 14, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Targeted Silencing of Kim-1 Inhibits the Growth of Clear Cell Renal Carcinoma Cell Line 786-0 In Vitro and In Vivo.
Conclusion, knockdown of Kim-1 inhibits the growth of 786-0 cells in vitro and in vivo, investing Kim-1 can be used as a potential target for clear cell renal carcinoma therapy. PMID: 29295730 [PubMed - as supplied by publisher]
Source: Oncology Research - January 5, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-136 inhibits malignant progression of hepatocellular carcinoma cells by targeting cyclooxygenase 2.
In conclusion, miR-136 was vital in the regulation of HCC cell proliferation and metastasis by targeting COX2. Thus, our findings provided novel evidence that miR-136 might be recommended as a potential target for the diagnosis and treatment of HCC patients. PMID: 29295728 [PubMed - as supplied by publisher]
Source: Oncology Research - January 5, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Epigenetic silence of HOTAIR contributes to the metastasis of pancreatic cancer via targeting miR-138.
Authors: Nie H, Zhang Y, Xing R, Li M, Mou Y Abstract Pancreatic cancer (PC) is one of the most common malignant tumors in digestive tract. The expression of HOX transcriptantisense RNA (HOTAIR) is positively correlated with TNM staging of PC. Our study aims to investigate the effect and the related mechanism of HOTAIR on the invasion and migration ability of PC cells. We found that the expression of HOTAIR was significantly increased in PC tissues and four PC cell lines (PANC-1, SW1990, CAPAN-1 aand JF305) compared with normal tissues and human pancreatic HPDE6-c7 cells. HOTAIR was then silenced by transfecting si...
Source: Oncology Research - December 23, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Non-SMC Condensin I Complex, Subunit G (NCAPG) is a Novel Mitotic Gene Required for Hepatocellular Cancer Cell Proliferation and Migration.
Authors: Zhang Q, Su R, Shan C, Gao C, Wu P Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Currently, only chemoembolization and sorafenib have shown survival benefits for advanced HCC. There are major unmet needs in HCC management and the discovery of new therapeutic targets. Here, we identified that NCAPG(non-SMC condensin I complex, subunit G) as a novel mitotic gene required for HCC cell proliferation and migration through siRNA knockdown of a panel of novel overexpressed genes in HCC based on The Cancer Genome Atlas (TCGA) dataset. We found that knockdow...
Source: Oncology Research - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Long Intergenic Noncoding RNA 319 (linc00319) Promotes Cell Proliferation and Invasion in Lung Cancer Cells by Directly Downregulating the Tumor Suppressor MiR-32.
In conclusion, linc00319 promotes cell proliferation and invasion in lung cancer cells by directly binding with and downregulating the tumor suppressor miR-32. PMID: 28800794 [PubMed - as supplied by publisher]
Source: Oncology Research - August 14, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-449a Suppresses LDHA-Mediated Glycolysis to Enhance the Sensitivity of Non-Small Cell Lung Cancer Cells to Ionizing Radiation.
Authors: Li L, Liu H, Du L, Xi P, Wang Q, Li Y, Liu D Abstract MicroRNA dysregulation contributes to malignant progression, dissemination and profound treatment resistance in multiple cancers. MiR-449a is recognized as a tumor suppresser. However, roles of miR-449a in lung cancers initiation and progression are largely unrevealed. Our study aims to investigate roles and the underlying mechanism of miR-449a in modulating sensitivity to ionizing radiation (IR) in non-small cell lung cancers (NSCLC). Lung cancer cells were transfected with miR-449a mimics or negative control and exposed to IR, levels of target protein...
Source: Oncology Research - August 14, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-26b Mimic Inhibits Glioma Proliferation In Vitro and In Vivo Suppressing COX-2 Expression.
Authors: Chen ZG, Zheng CY, Cai WQ, Li DW, Ye FY, Zhou J, Wu R, Yang K Abstract Glioma is the most common malignant tumor of the nervous system. Studies have shown the microRNA (miR)-26b/cyclooxygenase (COX)-2 axis in the development and progression in many tumor cells. Our study aims to investigate the effect and mechanism of miR-26b/COX-2 axis in glioma. Decreased expression of miR-26b with increased level of COX-2 was found in glioma tissues compared with matched normal tissues. A strong negative correlation was observed between the level of miR-26b and COX-2 in 30 glioma tissues. The miR-26b was then overexpres...
Source: Oncology Research - August 14, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Activation of Vimentin is Critical to Promote a Metastatic Potential of Cholangiocarcinoma Cells.
Authors: Saentaweesuk W, Araki N, Vaeteewoottacharn K, Silsirivanit A, Seubwai W, Talabnin C, Muisuk K, Sripa B, Wongkham S, Okada S, Wongkham C Abstract Cholangiocarcinoma (CCA) is a highly metastatic tumor, of which the majority of the patients have short survival due tono effective treatment. Hence, a better understanding regarding CCA metastasis may provide an opportunity to improve the strategies for treatment. A comparison study between the highly metastatic cells and their parental cells is an approach to uncover the molecular mechanisms underlying the metastatic process. In the present study, a lung metasta...
Source: Oncology Research - August 3, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research