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Source: Biochimica et Biophysica Acta

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Total 177 results found since Jan 2013.

Lethal (2) giant larvae regulates pleural mesothelial cell polarity in pleural fibrosis.
In this study, we observed that PMC polarity was lost in fibrotic pleura. Next we found increased Lethal (2) giant larvae (Lgl) bound with aPKC and PAR-6B competing against PAR-3A in PAR complex, which led to cell polarity loss. Then we demonstrated that Lgl1 siRNA prevented cell polarity loss in PMCs, and Lgl1 conditional knockout (ER-Cre+/-Lgl1flox/flox) attenuated pleural fibrosis in a mouse model. Our data indicated that Lgl1 regulates cell polarity of PMCs, inhibition of Lgl1 and maintenance of cell polarity in PMCs could be a potential therapeutic treatment approach for pleural fibrosis. PMID: 29842893 [PubMed -...
Source: Biochimica et Biophysica Acta - May 26, 2018 Category: Biochemistry Authors: Song LJ, Zhou LL, Wang M, Liu F, Xiong L, Xiang F, Yu F, He XL, Xu JJ, Shi HZ, Xin JB, Ma WL, Ye H Tags: Biochim Biophys Acta Source Type: research

Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells.
In conclusion, our data illustrate a novel epigenetic pathway that links PERP transcription to ROS-induced apoptosis in skeletal muscle cells. PMID: 30056131 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - July 26, 2018 Category: Biochemistry Authors: Li Z, Chen B, Dong W, Xu W, Song M, Fang M, Guo J, Xu Y Tags: Biochim Biophys Acta Source Type: research

Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis.
Abstract Psoriatic plaques tend to localize to the knees and elbows, areas that are particularly subject to mechanical stress resulting from bending and friction. Moreover, plaques often develop at sites of mechanical trauma or injury (Koebner phenomenon). Nevertheless, mechanotransduction has never been linked to psoriasis. Polycystins (polycystin-1, PC1; polycystin-2, PC2) are mechanosensitive molecules that function as key regulators of cellular mechanosensitivity and mechanotransduction. The aim of this in vitro study was to investigate the role of polycystins in the development of psoriasis. We showed that PC...
Source: Biochimica et Biophysica Acta - August 2, 2018 Category: Biochemistry Authors: Gargalionis AN, Malakou LS, Adamopoulos C, Piperi C, Theochari I, Nokhbehsaim M, Deschner J, Kokkalis G, Korkolopoulou P, Papadavid E, Papavassiliou AG, Basdra EK Tags: Biochim Biophys Acta Source Type: research

Expression of the tumor-expressed protein MageB2 enhances rRNA transcription
Biochim Biophys Acta Mol Cell Res. 2021 Mar 16:119015. doi: 10.1016/j.bbamcr.2021.119015. Online ahead of print.ABSTRACTAn essential requirement for cells to sustain a high proliferating rate is to be paired with enhanced protein synthesis through the production of ribosomes. For this reason, part of the growth-factor signaling pathways, are devoted to activate ribosome biogenesis. Enhanced production of ribosomes is a hallmark in cancer cells, which is boosted by different mechanisms. Here we report that the nucleolar tumor-protein MageB2, whose expression is associated with cell proliferation, also participates in riboso...
Source: Biochimica et Biophysica Acta - March 20, 2021 Category: Biochemistry Authors: Mar ía Fátima Ladelfa Leticia Yamila Peche Gast ón Ezequiel Amato Micaela Carolina Escalada Stefania Zampieri Franco Andr és Pascucci Andres Fernandez Benevento Dario Fernandez Do Porto Andrea Dardis Claudio Schneider Martin Monte Source Type: research

Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 May 22:158972. doi: 10.1016/j.bbalip.2021.158972. Online ahead of print.ABSTRACTBioactive N-acylethanolamines (NAEs) include palmitoylethanolamide, oleoylethanolamide, and anandamide, which exert anti-inflammatory, anorexic, and cannabimimetic actions, respectively. The degradation of NAEs has been attributed to two hydrolases, fatty acid amide hydrolase and NAE acid amidase (NAAA). Acid ceramidase (AC) is a lysosomal enzyme that hydrolyzes ceramide (N-acylsphingosine), which resembles NAAA in structure and function. In the present study, we examined the role of AC in the deg...
Source: Biochimica et Biophysica Acta - May 25, 2021 Category: Biochemistry Authors: Kazuhito Tsuboi Tatsuya Tai Ryouhei Yamashita Hanif Ali Takashi Watanabe Toru Uyama Yoko Okamoto Keisuke Kitakaze Yasuhiro Takenouchi Shinji Go Iffat Ara Sonia Rahman Hitoshi Houchi Tamotsu Tanaka Yasuo Okamoto Akira Tokumura Junko Matsuda Natsuo Ueda Source Type: research

TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts
This study assessed the effect of calcitriol on PRMT1-dependent fibroblast remodeling in human lung fibroblasts, and allergen-induced asthma in E3-rats. Fibroblasts were activated with thymic stromal lymphopoietin (TLSP); asthma was induced by ovalbumin inhalation in rats. The airway structure was assessed by immunohistology. Protein expression in fibroblasts and activation of the mitogen activated protein kinases were detected by Western-blotting. Transcription factor activation was determined by luciferase reporter assay. PRMT1 action was blocked by siRNA and PRMT-inhibition. Ovalbumin upregulated the expression of TSLP,...
Source: Biochimica et Biophysica Acta - June 20, 2021 Category: Biochemistry Authors: Ai Jin Xuemei Tang Weiqi Zhai Yuwen Li Qingzhu Sun Li Liu Xiaojun Yang Hui Ren Shemin Lu Source Type: research

RAGE and αVβ3-integrin are essential for suPAR signaling in podocytes
This study has examined the initial transduction steps used by suPAR in cultured mouse podocytes. We now report that the receptor for advanced glycation end-products (RAGE) co-immunoprecipitates with αV and β3 integrin subunits, which have previously shown to initiate suPAR signal transduction at the podocyte cell surface. siRNA knock-down of RAGE attenuated Src phosphorylation evoked by either suPAR or by glycated albumin (AGE-BSA), a prototypical RAGE agonist. suPAR effects on Src phosphorylation were also blocked by the structurally dissimilar RAGE antagonists FPS-ZM1 and azeliragon, as well as by cilengitide, an inhi...
Source: Biochimica et Biophysica Acta - June 24, 2021 Category: Biochemistry Authors: Eun Young Kim Stuart E Dryer Source Type: research

Caspase-3 and gasdermin E detection in peri-implantitis
In conclusion, our findings revealed a high expression of caspase-3 and GSDME in the inflamed biopsies of peri-implantitis and confirmed that the caspase-3/GSDME pathway mediates TNF-α-triggered pyroptosis in human gingival epithelium cells, which provides a new target for peri-implantitis treatment.PMID:34273529 | DOI:10.1016/j.bbadis.2021.166217
Source: Biochimica et Biophysica Acta - July 17, 2021 Category: Biochemistry Authors: Chaozhen Chen Zhiwei Jiang Qifeng Jiang Wei Dai Qin Shao Qianming Chen Ying Wang Guoli Yang Source Type: research

Induction of microRNA hsa-let-7d-5p, and repression of HMGA2, contribute protection against lipid accumulation in macrophage 'foam' cells
This study established that exposure to lipoproteins, including acetylated LDL, induced macrophage expression of microRNA hsa-let-7d-5p, a sequence previously linked with tumour suppression, and repressed expression of one of its target genes, high mobility group AT hook 2 (HMGA2). A let-7d-5p mimic repressed expression of HMGA2 (18%; p<0.05) while a marked increase (2.9-fold; p<0.05) in expression of HMGA2 was noted in the presence of let-7d-5p inhibitor. Under these conditions, let-7d-5p mimic significantly (p<0.05) decreased total [10%], free [8%] and cholesteryl ester [21%] mass, while the inhibitor significan...
Source: Biochimica et Biophysica Acta - July 18, 2021 Category: Biochemistry Authors: Richard J Lightbody Janice M W Taylor Yvonne Dempsie Annette Graham Source Type: research

Caspase-3 and gasdermin E detection in peri-implantitis
In conclusion, our findings revealed a high expression of caspase-3 and GSDME in the inflamed biopsies of peri-implantitis and confirmed that the caspase-3/GSDME pathway mediates TNF-α-triggered pyroptosis in human gingival epithelium cells, which provides a new target for peri-implantitis treatment.PMID:34273529 | DOI:10.1016/j.bbadis.2021.166217
Source: Biochimica et Biophysica Acta - July 17, 2021 Category: Biochemistry Authors: Chaozhen Chen Zhiwei Jiang Qifeng Jiang Wei Dai Qin Shao Qianming Chen Ying Wang Guoli Yang Source Type: research

Deficiency of Heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21 < sup > cip1 < /sup > expression
Biochim Biophys Acta Mol Basis Dis. 2021 Jul 30:166233. doi: 10.1016/j.bbadis.2021.166233. Online ahead of print.ABSTRACTGenetic mutations in heat shock factor 4 (Hsf4) is associated with both congenital and age-related cataracts. Hsf4 regulates lens development through its ability to both activate and inhibit transcription. Previous studies suggested Hsf4 is involved in modulating cellular senescence depending on p21cip1 and p27 kip1 expression in MEF cells. Here, we found that Hsf4 acts as a suppressor of p21cip1 expression and plays an anti-senescence role during lens development. Knocking out Hsf4 facilitated UVB-induc...
Source: Biochimica et Biophysica Acta - August 2, 2021 Category: Biochemistry Authors: Xiukun Cui Chunxiao Du Simin Wan Dandan Wu Longjun Yan Jing Zhang Jing Li Hui Li Zhengyan Yang Hailong Zhang Jun Zhang Hongmei Mu Fengyan Zhang Xuyan Peng Mugen Liu Yanzhong Hu Source Type: research